scholarly journals Application of Bioinformatics Methodologies in the Fields of Skin Biology and Dermatology

10.5772/63799 ◽  
2016 ◽  
Author(s):  
Sidra Younis ◽  
Valeriia Shnayder ◽  
Miroslav Blumenberg
Keyword(s):  
Skin Biology

scholarly journals ‘Fish matters’: the relevance of fish skin biology to investigative dermatology

2010 ◽  
Vol 19 (4) ◽  
pp. 313-324 ◽  
Author(s):  
Sebastian Rakers ◽  
Marina Gebert ◽  
Sai Uppalapati ◽  
Wilfried Meyer ◽  
Paul Maderson ◽  
...  
Keyword(s):  
Fish Skin ◽  
Skin Biology

scholarly journals Leptin System in Obese Dog Skin: A Pilot Study

Animals ◽  
2020 ◽  
Vol 10 (12) ◽  
pp. 2338
Author(s):  
Margherita Maranesi ◽  
Antonio Di Loria ◽  
Cecilia Dall’Aglio ◽  
Diego Piantedosi ◽  
Elvio Lepri ◽  
...  
Keyword(s):  
Immune System ◽  
Skin Diseases ◽  
Skin Inflammation ◽  
Normal Weight ◽  
Hair Follicles ◽  
Obese Group ◽  
System Control ◽  
System Composition ◽  
Skin Biology

Obesity predisposes to several health problems including skin diseases. However, information on the relationship between obesity and skin disorders in pets is very scarce. Leptin (LEP) is mainly produced by adipose tissue and has a prominent role in skin biology. This study evaluated the LEP system in the skin of obese dogs compared to normal-weight animals. The investigation was carried out on 10 obese (Obese group) and 10 normal-weight (Normal-weight group) dogs through Real-time PCR and immunohistochemistry. Cells of skin associated immune system were also evaluated. No differences were evidenced between the two groups as well as skin inflammation. LEP differences were no significant, while LEPR transcript appeared 10-fold higher in obesedogs than in normal-weight ones. Immunostaining for both molecules was observed in several skin structures such as the epidermis, hair follicles, and glands. No differences appeared in the skin associated immune system composition. This study is a preliminary report showing that LEP system changes in obese dog skin. The increased LEPR expression observed in the obese group suggests that the receptor plays a modulating role in the system control. However, the exact role of LEPin the skin under obesity conditions needs further elucidation.

scholarly journals Shedding Light on the Effects of Calorie Restriction and Its Mimetics on Skin Biology

Nutrients ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 1529 ◽  
Author(s):  
Yeon Ja Choi
Keyword(s):  
Calorie Restriction ◽  
Skin Diseases ◽  
Skin Aging ◽  
Peroxisome Proliferator ◽  
Extrinsic Factors ◽  
Inflammatory Skin Diseases ◽  
Peroxisome Proliferator Activated Receptor ◽  
Beneficial Effects ◽  
Age Related ◽  
Skin Biology

During the aging process of an organism, the skin gradually loses its structural and functional characteristics. The skin becomes more fragile and vulnerable to damage, which may contribute to age-related diseases and even death. Skin aging is aggravated by the fact that the skin is in direct contact with extrinsic factors, such as ultraviolet irradiation. While calorie restriction (CR) is the most effective intervention to extend the lifespan of organisms and prevent age-related disorders, its effects on cutaneous aging and disorders are poorly understood. This review discusses the effects of CR and its alternative dietary intake on skin biology, with a focus on skin aging. CR structurally and functionally affects most of the skin and has been reported to rescue both age-related and photo-induced changes. The anti-inflammatory, anti-oxidative, stem cell maintenance, and metabolic activities of CR contribute to its beneficial effects on the skin. To the best of the author’s knowledge, the effects of fasting or a specific nutrient-restricted diet on skin aging have not been evaluated; these strategies offer benefits in wound healing and inflammatory skin diseases. In addition, well-known CR mimetics, including resveratrol, metformin, rapamycin, and peroxisome proliferator-activated receptor agonists, show CR-like prevention against skin aging. An overview of the role of CR in skin biology will provide valuable insights that would eventually lead to improvements in skin health.

Skin biology of reptiles and amphibians

1980 ◽  
Vol 79 (1-3) ◽  
pp. 115-126 ◽  
Author(s):  
E. Elkan ◽  
J. E. Cooper
Keyword(s):  
Few Data ◽  
Physical Features ◽  
Skin Biology

SynopsisThe Reptilia and Amphibia are two distinct groups of vertebrates. However, they show a number of similarities, such as ectothermy and ecdysis, and are therefore compared and contrasted in this paper.The physical features of the skin of reptiles and amphibians vary considerably; in the case of the amphibians the skin is usually relatively thin and may play a part in respiration while that of the reptile is often thick and impervious due to heavy keratinisation. Little is known of the ‘climate’ of the integument and there are relatively few data on its chemistry. Various pathogens may gain entry to the skin but usually this necessitates breaching the epithelium or taking advantage of existing damage.

DNA damage responses in skin biology—Implications in tumor prevention and aging acceleration

2009 ◽  
Vol 56 (2) ◽  
pp. 76-81 ◽  
Author(s):  
Makoto Nakanishi ◽  
Hiroyuki Niida ◽  
Hiroshi Murakami ◽  
Midori Shimada
Keyword(s):  
Dna Damage ◽  
Dna Damage Responses ◽  
Tumor Prevention ◽  
Skin Biology

Zinc and skin biology

2016 ◽  
Vol 611 ◽  
pp. 113-119 ◽  
Author(s):  
Youichi Ogawa ◽  
Tatsuyoshi Kawamura ◽  
Shinji Shimada
Keyword(s):  
Skin Biology

The role of P-cadherin in skin biology and skin pathology: lessons from the hair follicle

2015 ◽  
Vol 360 (3) ◽  
pp. 761-771 ◽  
Author(s):  
Liat Samuelov ◽  
Eli Sprecher ◽  
Ralf Paus
Keyword(s):  
Hair Follicle ◽  
Skin Biology
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