scholarly journals Stem Cell Therapies for Cervical Spinal Cord Injury

10.5772/63580 ◽  
2016 ◽  
Author(s):  
Vanessa M. Doulames ◽  
Laura M. Marquardt ◽  
Bhavaani Jayaram ◽  
Christine D. Plant ◽  
Giles W. Plant
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Stem Cell ◽  
Cervical Spinal Cord ◽  
Cervical Spinal Cord Injury ◽  
Stem Cell Therapies ◽  
Cell Therapies ◽  
Cord Injury

scholarly journals Differential Response in Novel Stem Cell Niches of the Brain after Cervical Spinal Cord Injury and Traumatic Brain Injury

2018 ◽  
Vol 35 (18) ◽  
pp. 2195-2207 ◽  
Author(s):  
Aditi Falnikar ◽  
Jarred Stratton ◽  
Ruihe Lin ◽  
Carrie E. Andrews ◽  
Ashley Tyburski ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Stem Cell ◽  
Brain Injury ◽  
Cervical Spinal Cord ◽  
Cervical Spinal Cord Injury ◽  
Cord Injury ◽  
The Brain ◽  
Stem Cell Niches

scholarly journals Stem cell therapies for acute spinal cord injury in humans: a review

2019 ◽  
Vol 46 (3) ◽  
pp. E10 ◽  
Author(s):  
Michael C. Jin ◽  
Zachary A. Medress ◽  
Tej D. Azad ◽  
Vanessa M. Doulames ◽  
Anand Veeravagu
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Spinal Cord Injury ◽  
Stem Cell ◽  
Cell Biology ◽  
Stem Cell Biology ◽  
Stem Cell Therapies ◽  
Cell Therapies ◽  
Recent Advances ◽  
Cord Injury

Recent advances in stem cell biology present significant opportunities to advance clinical applications of stem cell–based therapies for spinal cord injury (SCI). In this review, the authors critically analyze the basic science and translational evidence that supports the use of various stem cell sources, including induced pluripotent stem cells, oligodendrocyte precursor cells, and mesenchymal stem cells. They subsequently explore recent advances in stem cell biology and discuss ongoing clinical translation efforts, including combinatorial strategies utilizing scaffolds, biogels, and growth factors to augment stem cell survival, function, and engraftment. Finally, the authors discuss the evolution of stem cell therapies for SCI by providing an overview of completed (n = 18) and ongoing (n = 9) clinical trials.

scholarly journals Current progress of rehabilitative strategies in stem cell therapy for spinal cord injury: a review

2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Syoichi Tashiro ◽  
Osahiko Tsuji ◽  
Munehisa Shinozaki ◽  
Takahiro Shibata ◽  
Takashi Yoshida ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Stem Cell ◽  
Functional Recovery ◽  
Synergistic Effects ◽  
Regenerative Therapy ◽  
Stem Cell Therapies ◽  
Cell Therapies ◽  
Functional Training ◽  
Cord Injury

AbstractStem cell-based regenerative therapy has opened an avenue for functional recovery of patients with spinal cord injury (SCI). Regenerative rehabilitation is attracting wide attention owing to its synergistic effects, feasibility, non-invasiveness, and diverse and systemic properties. In this review article, we summarize the features of rehabilitation, describe the mechanism of combinatorial treatment, and discuss regenerative rehabilitation in the context of SCI. Although conventional rehabilitative methods have commonly been implemented alone, especially in studies of acute-to-subacute SCI, the combinatorial effects of intensive and advanced methods, including various neurorehabilitative approaches, have also been reported. Separating the concept of combined rehabilitation from regenerative rehabilitation, we suggest that the main roles of regenerative rehabilitation can be categorized as conditioning/reconditioning, functional training, and physical exercise, all of which are indispensable for enhancing functional recovery achieved using stem cell therapies.

scholarly journals Stem cell therapies for spinal cord injury

2010 ◽  
Vol 6 (7) ◽  
pp. 363-372 ◽  
Author(s):  
Vibhu Sahni ◽  
John A. Kessler
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Stem Cell ◽  
Stem Cell Therapies ◽  
Cell Therapies ◽  
Cord Injury

scholarly journals Neural stem cell mediated recovery is enhanced by Chondroitinase ABC pretreatment in chronic cervical spinal cord injury

PLoS ONE ◽  
2017 ◽  
Vol 12 (8) ◽  
pp. e0182339 ◽  
Author(s):  
Hidenori Suzuki ◽  
Christopher S. Ahuja ◽  
Ryan P. Salewski ◽  
Lijun Li ◽  
Kajana Satkunendrarajah ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Stem Cell ◽  
Neural Stem Cell ◽  
Cervical Spinal Cord ◽  
Cervical Spinal Cord Injury ◽  
Chondroitinase Abc ◽  
Cord Injury
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