scholarly journals Interstitial Chemotherapy for Malignant Gliomas

10.5772/62838 ◽  
2016 ◽  
Author(s):  
Ke Sai ◽  
Shuxin Sun ◽  
Zhongping Chen
Keyword(s):  
Malignant Gliomas ◽  
Interstitial Chemotherapy

Repeated Implantation of Interstitial Chemotherapy to Treat Malignant Gliomas

2008 ◽  
Vol 18 (4) ◽  
pp. 286-289 ◽  
Author(s):  
Joseph P. Krzeminski ◽  
Josep Piquer ◽  
Pedro Riesgo
Keyword(s):  
Malignant Gliomas ◽  
Interstitial Chemotherapy

Interstitial chemotherapy with drug polymer implants for the treatment of recurrent gliomas

1991 ◽  
Vol 74 (3) ◽  
pp. 441-446 ◽  
Author(s):  
Henry Brem ◽  
M. Stephen Mahaley ◽  
Nicholas A. Vick ◽  
Keith L. Black ◽  
S. Clifford Schold ◽  
...  
Keyword(s):  
Malignant Glioma ◽  
Dose Group ◽  
Malignant Gliomas ◽  
Chemotherapeutic Agents ◽  
Therapeutic Drug ◽  
Recurrent Malignant Glioma ◽  
Content Type ◽  
Interstitial Chemotherapy ◽  
Bcnu Wafer ◽  
Fine Print

✓ Malignant gliomas have been difficult to treat with chemotherapy. The most effective agent, BCNU (carmustine), has considerable systemic toxicity and a short half-life in serum. To obviate these problems, a method has been developed for the local sustained release of chemotherapeutic agents by their incorporation into biodegradable polymers. Implantation of the drug-impregnated polymer at the tumor site allows prolonged local exposure with minimal systemic exposure. In this Phase I–II study, 21 patients with recurrent malignant glioma were treated with BCNU released interstitially by means of a polyanhydride biodegradable polymer implant. Up to eight polymer wafers were placed in the resection cavity intraoperatively, upon completion of tumor debulking. The polymer releases the therapeutic drug for approximately 3 weeks. Three increasing concentrations of BCNU were studied; the treatment was well tolerated at all three levels. There were no adverse reactions to the BCNU wafer treatment itself The average survival period after reoperation was 65 weeks for the first dose group, 64 weeks for the second dose group, and 32 weeks for the highest dose group. The overall mean survival time was 48 weeks from reoperation and 94 weeks from the original operation. The overall median survival times were 46 weeks postimplant and 87 weeks from initial surgery. Eighteen (86%) of 21 patients lived more than 1 year from the time of their initial diagnosis and eight (38%) of 21 patients lived more than 1 year after intracranial implantation of the polymer. Frequent hematology, blood chemistry, and urinalysis tests did not reveal any systemic effect from this interstitial chemotherapy. Since the therapy is well tolerated and safe, a placebo-controlled clinical trial has been started. The trial will measure the effect of the second treatment dose on survival of patients with recurrent malignant glioma.

The safety of interstitial chemotherapy with BCNU-loaded polymer followed by radiation therapy in the treatment of newly diagnosed malignant gliomas: Phase I trial

1995 ◽  
Vol 26 (2) ◽  
pp. 111-123 ◽  
Author(s):  
Henry Brem ◽  
Matthew G. Ewend ◽  
Steven Piantadosi ◽  
Jerry Greenhoot ◽  
Peter C. Burger ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Phase I ◽  
Phase I Trial ◽  
Malignant Gliomas ◽  
Newly Diagnosed ◽  
Interstitial Chemotherapy

scholarly journals Interstitial chemotherapy for malignant gliomas: the Johns Hopkins experience

2006 ◽  
Vol 83 (1) ◽  
pp. 61-70 ◽  
Author(s):  
H. Christopher Lawson ◽  
Prakash Sampath ◽  
Eileen Bohan ◽  
Michael C. Park ◽  
Namath Hussain ◽  
...  
Keyword(s):  
Malignant Gliomas ◽  
Interstitial Chemotherapy

Nucleic Acid-based Technologies in Therapy of Malignant Gliomas

2011 ◽  
Vol 12 (11) ◽  
pp. 1805-1822 ◽  
Author(s):  
Monika Piwecka ◽  
Katarzyna Rolle ◽  
Eliza Wyszko ◽  
Ryszard Zukiel ◽  
Stanislaw Nowak ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Malignant Gliomas
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