scholarly journals Insulin Gene Therapy for Type 1 Diabetes Mellitus: Unique Challenges Require Innovative Solutions

10.5772/62657 ◽  
2016 ◽  
Author(s):  
Andrew M. Handorf ◽  
Hans W. Sollinger ◽  
Tausif Alam
Keyword(s):  
Diabetes Mellitus ◽  
Gene Therapy ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Insulin Gene ◽  
Innovative Solutions

scholarly journals Gene Therapy to Improve Pancreatic Islet Transplantation for Type 1 Diabetes Mellitus

2010 ◽  
Vol 6 (5) ◽  
pp. 274-284 ◽  
Author(s):  
Amy Hughes ◽  
Claire Jessup ◽  
Chris Drogemuller ◽  
Daisy Mohanasundaram ◽  
Clyde Milner ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gene Therapy ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Islet Transplantation ◽  
Pancreatic Islet ◽  
Pancreatic Islet Transplantation

scholarly journals Gene therapy and type 1 diabetes mellitus

2018 ◽  
Vol 108 ◽  
pp. 1188-1200 ◽  
Author(s):  
Dinesh Kumar Chellappan ◽  
Nandhini S. Sivam ◽  
Kai Xiang Teoh ◽  
Wai Pan Leong ◽  
Tai Zhen Fui ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gene Therapy ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus

Type 1 Diabetes and Prediabetic State in a Monozygotic Triplet

1998 ◽  
Vol 47 (3-4) ◽  
pp. 171-176
Author(s):  
M. Krokowski ◽  
M. Abel ◽  
A. Teodorczyk ◽  
A. Szadkowska ◽  
B. Pyrżak ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Genetic Predisposition ◽  
Gene Polymorphisms ◽  
Insulin Gene ◽  
Prediabetic State ◽  
Apo B ◽  
Clinical Onset

AbstractType 1 diabetes mellitus (IDDM) results from a chronic process of autoimmune destruction of ß cells of the Langerhans islets. The presence of autoantibodies (ICA, GADA, anti-IA2, IAA) in serum preceds the clinical onset of the disease. Genetic predisposition for IDDM is connected with HLA, CTLA-4 and insulin gene region.The aim of the study was the genetic and immunological analysis of a triplet. One of them developed Type 1 diabetes mellitus. We analysed HLA class II, CTLA-4 and insulin gene polymorphisms in the whole family. Besides, we investigated immunological status of three brothers.All patients present identical genotype for VNTR loci: D1S80, D17S5 and Apo B, as well as for HLA-DRB1, — DQA1, — DQB1, CTLA-4 gene and all studied insulin gene polymorphisms. That proves their monozigosity. The triplet presents strong genetic predisposition for IDDM. The two patients without overt diabetes have increased levels of ICA, GADA, IA2 and IAA.

Association of HLA-DQB1,-DQA1,-DRB1*04 and insulin gene polymorphism with type 1 diabetes mellitus in Czech children

2000 ◽  
Vol 50 ◽  
pp. 93
Author(s):  
Jan Vavrinec ◽  
Ondrej Cinek ◽  
Zdenek Šumnik ◽  
Stanislava Kolouškova ◽  
Katerina Štechova ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Gene Polymorphism ◽  
Type 1 Diabetes Mellitus ◽  
Insulin Gene ◽  
Insulin Gene Polymorphism

scholarly journals Hepatic Insulin Gene Expression as Treatment for Type 1 Diabetes Mellitus in Rats

1997 ◽  
Vol 11 (6) ◽  
pp. 833-837 ◽  
Author(s):  
Patrick Muzzin ◽  
Randy C. Eisensmith ◽  
Kenneth C. Copeland ◽  
Savio L. C. Woo
Keyword(s):  
Gene Expression ◽  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Insulin Gene ◽  
Insulin Gene Expression

scholarly journals The Role of Gene Therapy in the Treatments of Type 1 Diabetes Mellitus: a review

2020 ◽  
Vol 9 (2) ◽  
pp. 57-64
Author(s):  
Harem Othman Smail
Keyword(s):  
Diabetes Mellitus ◽  
Gene Therapy ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Diabetes Type ◽  
Molecular Medicine ◽  
Treatment And Prevention ◽  
Pancreatic Damage

The main aims of this review were to understand the roles of gene therapy in the treatment and prevention of type 1 diabetes mellitus and I will discuss a brief history, approaches, vector types with the future of diabetes following clinical use. Type 1 diabetes mellitus is a metabolic condition that is identified by insufficient insulin development due to pancreatic damage to beta cells. Control, long life, and diagnosis of these metabolic disorders have become vital sources for many scientists and researchers. After 2000, the latest approaches to molecular medicine were introduced as one of the possible therapeutic options for diabetes type 1 diagnosis. Many genes have been reported as a clinical trial so that damaged genes can be treated and three main approaches shown about 50 years ago are islet transplantation, β cell regeneration, and insulin gene therapy to cure and prevent diabetes type. Treating diabetes through gene therapy can promise children and adolescents, but more clinical applications are needed to recognize it as a permanent route.

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