scholarly journals Pharmacological Inhibition of Intracellular Signaling Pathways in Radioresistant Anaplastic Thyroid Cancer

10.5772/62541 ◽  
2016 ◽  
Author(s):  
Dmitry Bulgin ◽  
Alexey Podcheko
Keyword(s):  
Thyroid Cancer ◽  
Signaling Pathways ◽  
Intracellular Signaling ◽  
Anaplastic Thyroid Cancer ◽  
Pharmacological Inhibition ◽  
Intracellular Signaling Pathways

scholarly journals Pathological processes and therapeutic advances in radioiodide refractory thyroid cancer

2017 ◽  
Vol 59 (4) ◽  
pp. R141-R154 ◽  
Author(s):  
Marika H Tesselaar ◽  
Johannes W Smit ◽  
James Nagarajah ◽  
Romana T Netea-Maier ◽  
Theo S Plantinga
Keyword(s):  
Thyroid Cancer ◽  
Signaling Pathways ◽  
Intracellular Signaling ◽  
Medullary Thyroid Cancer ◽  
Disease Remission ◽  
Intracellular Signaling Pathways ◽  
Oncogenic Mutations ◽  
Diagnostics And Therapy ◽  
Disease Present

While in most patients with non-medullary thyroid cancer (TC), disease remission is achieved by thyroidectomy and ablation of tumor remnants by radioactive iodide (RAI), a substantial subgroup of patients with metastatic disease present tumor lesions that have acquired RAI resistance as a result of dedifferentiation. Although oncogenic mutations inBRAF,TERTpromoter andTP53are associated with an increased propensity for induction of dedifferentiation, the role of genetic and epigenetic aberrations and their effects on important intracellular signaling pathways is not yet fully elucidated. Also immune, metabolic, stemness and microRNA pathways have emerged as important determinants of TC dedifferentiation and RAI resistance. These signaling pathways have major clinical implications since their targeting could inhibit TC progression and could enable redifferentiation to restore RAI sensitivity. In this review, we discuss the current insights into the pathological processes conferring dedifferentiation and RAI resistance in TC and elaborate on novel advances in diagnostics and therapy to improve the clinical outcome of RAI-refractory TC patients.

scholarly journals Interaction of dual intracellular signaling pathways activated by the melanocortin-3 receptor.

1994 ◽  
Vol 269 (18) ◽  
pp. 13162-13166
Author(s):  
Y. Konda ◽  
I. Gantz ◽  
J. DelValle ◽  
Y. Shimoto ◽  
H. Miwa ◽  
...  
Keyword(s):  
Signaling Pathways ◽  
Intracellular Signaling ◽  
Intracellular Signaling Pathways
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