scholarly journals Dynamics of Cancer-Related Proteins in Patients with Bladder Cancer

10.5772/62525 ◽  
2016 ◽  
Author(s):  
Kazumasa Matsumoto ◽  
Morihiro Nishi ◽  
Hideyasu Tsumura ◽  
Ken-ichi Tabata ◽  
Tetsuo Fujita ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Related Proteins

MiR-301b promotes the proliferation, mobility, and epithelial-to-mesenchymal transition of bladder cancer cells by targeting EGR1

2017 ◽  
Vol 95 (5) ◽  
pp. 571-577 ◽  
Author(s):  
Lei Yan ◽  
Yan Wang ◽  
Jun Liang ◽  
Zhixin Liu ◽  
Xiaodong Sun ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Epithelial To Mesenchymal Transition ◽  
Luciferase Reporter ◽  
Migration And Invasion ◽  
Luciferase Reporter Gene ◽  
Mesenchymal Transition ◽  
Normal Tissues ◽  
Early Growth Response Gene ◽  
Bladder Cancer Cells ◽  
Related Proteins

We investigated the role of miR-301b in the modulation of the proliferation, migration, and invasion of bladder cancer (BLCA) cells. The expression of miR-301b and EGR1 (early growth response gene 1) mRNA were analyzed by quantitative real-time polymerase chain reaction (qRT-PCR). A dual-luciferase reporter gene system was used to identify the target relationship between miR-301b and EGR1. Cell proliferation, cell cycle, and apoptosis were analyzed by MTT assay, colony-forming assay, and flow cytometry, respectively. Cell motility and invasiveness were assessed by wound healing and Transwell assays. The expression of proteins involved in epithelial-to-mesenchymal transition (EMT) and EGR1 were determined by Western blot. Our results showed that miR-301b was up-regulated while EGR1 was down-regulated in BLCA tissues compared with adjacent normal tissues. The proliferation, migration, and invasiveness of T24 cells (a kind of human BLCA cell) were suppressed by decreasing miR-301b expression or increasing EGR1 expression. In addition, miR-301b promoted EMT signaling by influencing the expression of related proteins. In conclusion, miR-301b promotes the proliferation, migration, and aggressiveness of human BLCA cells by inhibiting the expression of EGR1.

390 THE ROLE OF AKT PATHWAY RELATED PROTEINS AS PREDICTORS OF TUMOR PROGRESSION IN SUPERFICIAL BLADDER CANCER

2007 ◽  
Vol 6 (2) ◽  
pp. 120
Author(s):  
M. Kramer ◽  
A.S. Merseburger ◽  
J. Hennenlotter ◽  
A. Stenzl ◽  
M.A. Kuczyk
Keyword(s):  
Bladder Cancer ◽  
Tumor Progression ◽  
Superficial Bladder Cancer ◽  
Akt Pathway ◽  
Related Proteins

Hypoxia-Inducible Factors HIF-1α and HIF-2α Expression in Bladder Cancer and Their Associations with Other Angiogenesis-Related Proteins

2006 ◽  
Vol 77 (3) ◽  
pp. 255-263 ◽  
Author(s):  
E. Ioachim ◽  
M. Michael ◽  
M. Salmas ◽  
M.M. Michael ◽  
N.E. Stavropoulos ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Hypoxia Inducible Factors ◽  
Related Proteins

scholarly journals The impact of advanced proteomics in the search for markers and therapeutic targets of bladder cancer

Tumor Biology ◽  
2017 ◽  
Vol 39 (3) ◽  
pp. 101042831769118 ◽  
Author(s):  
Hongshuo Zhang ◽  
Yue Fan ◽  
Lingling Xia ◽  
Chunhui Gao ◽  
Xin Tong ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Genetic Factors ◽  
Therapeutic Response ◽  
Biomarker Discovery ◽  
High Sensitivity ◽  
Current Status ◽  
Common Cancer ◽  
Related Proteins ◽  
Future Work ◽  
The Impact

Bladder cancer is the most common cancer of the urinary tract and can be avoided through proper surveillance and monitoring. Several genetic factors are known to contribute to the progression of bladder cancer, many of which produce molecules that serve as cancer biomarkers. Blood, urine, and tissue are commonly analyzed for the presence of biomarkers, which can be derived from either the nucleus or the mitochondria. Recent advances in proteomics have facilitated the high-throughput profiling of data generated from bladder cancer–related proteins or peptides in parallel with high sensitivity and specificity, providing a wealth of information for biomarker discovery and validation. However, the transmission of screening results from one laboratory to another remains the main disadvantage of these methods, a fact that emphasizes the need for consistent and standardized procedures as suggested by the Human Proteome Organization. This review summarizes the latest discoveries and progress of biomarker identification for the early diagnosis, projected prognosis, and therapeutic response of bladder cancer, informs the readers of the current status of proteomic-based biomarker findings, and suggests avenues for future work.

scholarly journals MP45-12 PROGNOSTIC VALUE OF DNA DAMAGE RESPONSE RELATED PROTEINS IN NON-MUSCLE INVASIVE BLADDER CANCER

2016 ◽  
Vol 195 (4S) ◽  
Author(s):  
Albert Frances ◽  
Nuria Juanpere ◽  
Judith Penafiel ◽  
Gloria Nohales ◽  
Cristina Camara ◽  
...  
Keyword(s):  
Dna Damage ◽  
Bladder Cancer ◽  
Dna Damage Response ◽  
Prognostic Value ◽  
Invasive Bladder Cancer ◽  
Muscle Invasive Bladder Cancer ◽  
Damage Response ◽  
Muscle Invasive ◽  
Related Proteins

DNA-fragmentation and expression of apoptosis-related proteins in experimentally denervated and reinnervated rat facial muscle

1997 ◽  
Vol 23 (3) ◽  
pp. 141-149 ◽  
Author(s):  
D. S. Tews ◽  
H. H. Goebel ◽  
I. Schneider ◽  
A. Gunkel ◽  
E. Stennert ◽  
...  
Keyword(s):  
Dna Fragmentation ◽  
Facial Muscle ◽  
Related Proteins

Sex and Racial Disparities in the Treatment and Outcomes of Muscle-invasive Bladder Cancer

Urology ◽  
2020 ◽  
Author(s):  
Jessica Marinaro ◽  
Alexander Zeymo ◽  
Jillian Egan ◽  
Filipe Carvalho ◽  
Ross Krasnow ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Racial Disparities ◽  
Invasive Bladder Cancer ◽  
Muscle Invasive Bladder Cancer ◽  
Muscle Invasive
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