scholarly journals Matrix Metalloproteinases in Asthma-Associated Airway Remodeling – Dr. Jekyll or Mr. Hyde ?

10.5772/62440 ◽  
2016 ◽  
Author(s):  
Katarzyna Grzela ◽  
Agnieszka Strzelak ◽  
Wioletta Zagórska ◽  
Tomasz Grzela
Keyword(s):  
Matrix Metalloproteinases ◽  
Airway Remodeling

scholarly journals Matrix metalloproteinases and airway remodeling and function in primary ciliary dyskinesia

2017 ◽  
Vol 124 ◽  
pp. 49-56 ◽  
Author(s):  
Massimo Pifferi ◽  
Andrew Bush ◽  
Davide Caramella ◽  
Maria Rita Metelli ◽  
Maria Di Cicco ◽  
...  
Keyword(s):  
Matrix Metalloproteinases ◽  
Primary Ciliary Dyskinesia ◽  
Airway Remodeling ◽  
And Function ◽  
Ciliary Dyskinesia

scholarly journals MATRIX METALLOPROTEINASES AS MARKERS OF RESPIRATORY TRACT REMODELING AND POTENTIAL THERAPEUTIC TARGET IN PATIENTS WITH BRONCHIAL ASTHMA

2021 ◽  
Vol 9 (2) ◽  
pp. 174-188
Author(s):  
Vladyslava V. Kachkovska
Keyword(s):  
Matrix Metalloproteinases ◽  
Matrix Metalloproteinase ◽  
Bronchial Asthma ◽  
Airway Remodeling ◽  
Matrix Metalloproteinase 9 ◽  
Bronchial Obstruction ◽  
Therapeutic Effects ◽  
External Respiration ◽  
Metalloproteinase 9

It is evidently known that chronic inflammatory process in the bronchi of patients with bronchial asthma is associated with the emergence and progression of airway remodeling, resulting in irreversible obstruction. However, the exact mechanisms of connection between inflammation and airway remodeling are not very well understood and that is the reason for delay of development new specific targeted drugs aimed to inhibit the process of inflammation and remodeling. Therefore, our goal was aimed to analyze and systematize data on the role of matrix metalloproteinases in the occurrence of airway remodeling in patients with bronchial asthma and the possibility of therapeutic effects on this process. Materials and methods: search for information on the role and mechanisms of influence of matrix metalloproteinases on airway remodeling processes in patients with bronchial asthma and the possibility of its pharmacological correction in electronic databases such as PubMed and Google Scholar over the past 25 years. Matrix metalloproteinase-9 and tissue proteinase-1 inhibitor have been shown to play the most important role in airway remodeling in the presence of bronchial asthma, supported by numerous experimental and clinical studies. Much attention is paid to the comparison of these indicators in bronchoalveolar lavage, induced sputum and blood on the background of exacerbation and in the presence of a stable course of the disease. The analysis of their content depending on the severity of the course, dysfunction of external respiration and the degree of reversibility of bronchial obstruction. Studies of the possibility of drug effects on the content of remodeling markers have shown low clinical efficacy. The results are contradictory, but most of them prove the important role of matrix metalloproteinase-9, tissue protease inhibitor-1 and their relationship in the occurrence and progression of airway remodeling and, consequently, the severity of the disease, which dictates the need to develop new additional treatments.

scholarly journals Role of Matrix Metalloproteinases in Angiogenesis and Its Implications in Asthma

2021 ◽  
Vol 2021 ◽  
pp. 1-12
Author(s):  
Khuloud Bajbouj ◽  
Rakhee K. Ramakrishnan ◽  
Qutayba Hamid
Keyword(s):  
Extracellular Matrix ◽  
Matrix Metalloproteinases ◽  
Vascular Remodeling ◽  
Proteolytic Enzymes ◽  
Airway Remodeling ◽  
Inflammatory Cells ◽  
Bioactive Molecules ◽  
Matrix Remodeling ◽  
Pathological Conditions

Asthma is a chronic airway disorder associated with aberrant inflammatory and remodeling responses. Angiogenesis and associated vascular remodeling are one of the pathological hallmarks of asthma. The mechanisms underlying angiogenesis in asthmatic airways and its clinical relevance represent a relatively nascent field in asthma when compared to other airway remodeling features. Matrix metalloproteinases (MMPs) are proteases that play an important role in both physiological and pathological conditions. In addition to facilitating extracellular matrix turnover, these proteolytic enzymes cleave bioactive molecules, thereby regulating cell signaling. MMPs have been implicated in the pathogenesis of asthma by interacting with both the airway inflammatory cells and the resident structural cells. MMPs also cover a broad range of angiogenic functions, from the degradation of the vascular basement membrane and extracellular matrix remodeling to the release of a variety of angiogenic mediators and growth factors. This review focuses on the contribution of MMPs and the regulatory role exerted by them in angiogenesis and vascular remodeling in asthma as well as addresses their potential as therapeutic targets in ameliorating angiogenesis in asthma.

Cytokine synergy, collagenases and cartilage collagen breakdown

2003 ◽  
Vol 70 ◽  
pp. 125-133 ◽  
Author(s):  
Tim E. Cawston ◽  
Jenny M. Milner ◽  
Jon B. Catterall ◽  
Andrew D. Rowan
Keyword(s):  
Matrix Metalloproteinases ◽  
Inflammatory Cytokines ◽  
Activator Protein 1 ◽  
Activator Protein ◽  
And Cartilage ◽  
Pro Inflammatory Cytokines

We have investigated proteinases that degrade cartilage collagen. We show that pro-inflammatory cytokines act synergistically with oncastatin M to promote cartilage collagen resorption by the up-regulation and activation of matrix metalloproteinases (MMPs). The precise mechanisms are not known, but involve the up-regulation of c-fos, which binds to MMP promoters at a proximal activator protein-1 (AP-1) site. This markedly up-regulates transcription and leads to higher levels of active MMP proteins.

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