scholarly journals pH-Responsive Vesicles with Tunable Membrane Permeability and Hydrodynamic Diameters from a Cross-Linkable Amphiphilic Block Copolymer

10.5772/62151 ◽  
2016 ◽  
Vol 6 ◽  
pp. 6 ◽  
Author(s):  
Ruixue Chang ◽  
Yuelan Tian ◽  
Yong Wang ◽  
Jianglei Qin
Keyword(s):  
Block Copolymer ◽  
Membrane Permeability ◽  
Amphiphilic Block Copolymer ◽  
Ph Responsive

scholarly journals pH-responsive dithiomaleimide-amphiphilic block copolymer for drug delivery and cellular imaging

2019 ◽  
Vol 552 ◽  
pp. 439-447 ◽  
Author(s):  
Ting Bai ◽  
Dongyan Shao ◽  
Jianxin Chen ◽  
Yifan Li ◽  
Ben Bin Xu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Block Copolymer ◽  
Cellular Imaging ◽  
Amphiphilic Block Copolymer ◽  
Ph Responsive

scholarly journals Stimuli-Responsive Lyotropic Liquid Crystalline Nanosystems with Incorporated Poly(2-Dimethylamino Ethyl Methacrylate)-b-Poly(Lauryl Methacrylate) Amphiphilic Block Copolymer

Polymers ◽  
2019 ◽  
Vol 11 (9) ◽  
pp. 1400 ◽  
Author(s):  
Maria Chountoulesi ◽  
Natassa Pippa ◽  
Varvara Chrysostomou ◽  
Stergios Pispas ◽  
Evangelia D. Chrysina ◽  
...  
Keyword(s):  
Block Copolymer ◽  
Liquid Crystalline ◽  
Polymer Concentration ◽  
Morphological Characteristics ◽  
Amphiphilic Block Copolymer ◽  
Poloxamer 407 ◽  
Stimuli Responsive ◽  
Ph Responsive ◽  
Ethyl Methacrylate ◽  
Liquid Crystalline Nanoparticles

There is an emerging need to evolve the conventional lyotropic liquid crystalline nanoparticles to advanced stimuli-responsive, therapeutic nanosystems with upgraded functionality. Towards this effort, typically used stabilizers, such as Pluronics®, can be combined or replaced by smart, stimuli-responsive block copolymers. The aim of this study is to incorporate the stimuli-responsive amphiphilic block copolymer poly(2-(dimethylamino)ethyl methacrylate)-b-poly(lauryl methacrylate) (PDMAEMA-b-PLMA) as a stabilizer in lipidic liquid crystalline nanoparticles, in order to provide steric stabilization and simultaneous stimuli-responsiveness. The physicochemical and morphological characteristics of the prepared nanosystems were investigated by light scattering techniques, cryogenic-transmission electron microscopy (cryo-TEM), X-ray diffraction (XRD) and fluorescence spectroscopy. The PDMAEMA-b-PLMA, either individually or combined with Poloxamer 407, exhibited different modes of stabilization depending on the lipid used. Due to the protonation ability of PDMAEMA blocks in acidic pH, the nanoparticles exhibited high positive charge, as well as pH-responsive charge conversion, which can be exploited towards pharmaceutical applications. The ionic strength, temperature and serum proteins influenced the physicochemical behavior of the nanoparticles, while the polymer concentration differentiated their morphology; their micropolarity and microfluidity were also evaluated. The proposed liquid crystalline nanosystems can be considered as novel and attractive pH-responsive drug and gene delivery nanocarriers due to their polycationic content.

scholarly journals Mesoscale Simulations of pH-Responsive Amphiphilic Polymeric Micelles for Oral Drug Delivery

Pharmaceutics ◽  
2019 ◽  
Vol 11 (12) ◽  
pp. 620 ◽  
Author(s):  
Zhimin Wu ◽  
Manzhen Duan ◽  
Di Xiong ◽  
Can Yang Zhang
Keyword(s):  
Drug Delivery ◽  
Block Copolymer ◽  
Self Assembly ◽  
Polymeric Micelles ◽  
Drug Carrier ◽  
Drug Distribution ◽  
Amphiphilic Block Copolymer ◽  
Oral Drug ◽  
Structure Property ◽  
Ph Responsive

It is of great significance to study the structure property and self-assembly of amphiphilic block copolymer in order to effectively and efficiently design and prepare drug delivery systems. In this work, dissipative particle dynamics (DPD) simulation method was used to investigate the structure property and self-assembly ability of pH-responsive amphiphilic block copolymer poly(methyl methacrylate-co-methacrylic acid)-b-poly(aminoethyl methacrylate) (poly(MMA-co-MAA)-b-PAEMA). The effects of different block ratios (hydrophilic PAEMA segment and pH-sensitive PMAA segment) in copolymer on self-assembly and drug loading capacity including drug distribution were extensively investigated. The increase of hydrophilic PAEMA facilitated the formation of a typical core-shell structure as well as a hydrophobic PMAA segment. Furthermore, the optimal drug-carrier ratio was confirmed by an analysis of the drug distribution during the self-assembly process of block copolymer and model drug Ibuprofen (IBU). In addition, the drug distribution and nanostructure of IBU-loaded polymeric micelles (PMs) self-assembled from precise block copolymer (PMMA-b-PMAA-b-PAEMA) and block copolymer (poly(MMA-co-MAA)-b-PAEMA) with random pH-responsive/hydrophobic structure were evaluated, showing that almost all drug molecules were encapsulated into a core for a random copolymer compared to the analogue. The nanostructures of IBU-loaded PMs at different pH values were evaluated. The results displayed that the nanostructure was stable at pH < pKa and anomalous at pH > pKa which indicated drug release, suggesting that the PMs could be used in oral drug delivery. These findings proved that the amphiphilic block copolymer P(MMA30-co-MAA33)-b-PAEMA38 with random structure and pH-sensitivity might be a potential drug carrier. Moreover, DPD simulation shows potential to study the structure property of PMs self-assembled from amphiphilic block copolymer.

Aggregation-induced emission polymer nanoparticles with pH-responsive fluorescence

2016 ◽  
Vol 7 (34) ◽  
pp. 5386-5395 ◽  
Author(s):  
Yuming Zhao ◽  
Wen Zhu ◽  
Lixia Ren ◽  
Ke Zhang
Keyword(s):  
Block Copolymer ◽  
Efficient Method ◽  
Self Assembly ◽  
Polymer Nanoparticles ◽  
Amphiphilic Block Copolymer ◽  
Ph Responsive ◽  
Aggregation Induced Emission ◽  
Post Functionalization

A convenient and efficient method was developed to prepare stable polymer nanoparticles with varied morphology and pH-responsive AIE properties, based on the amphiphilic block copolymer self-assembly, crosslinking, and post-functionalization techniques.

The Self-Assembly of an Amphiphilic Block Copolymer: A Dissipative Particle Dynamics Study

2005 ◽  
Vol 42 (3) ◽  
pp. 180-183 ◽  
Author(s):  
S. G. Schulz ◽  
U. Frieske ◽  
H. Kuhn ◽  
G. Schmid ◽  
F. Müller ◽  
...  
Keyword(s):  
Block Copolymer ◽  
Self Assembly ◽  
Dissipative Particle Dynamics ◽  
Particle Dynamics ◽  
The Self ◽  
Amphiphilic Block Copolymer

β-lactam Functionalized Poly(isoprene-b-ethylene oxide) Amphiphilic Block Copolymer Micelles as a New Nanocarrier System for Curcumin

2010 ◽  
Vol 6 (3) ◽  
pp. 277-284 ◽  
Author(s):  
Konstantinos Gardikis ◽  
Konstantinos Dimas ◽  
Aristidis Georgopoulos ◽  
Eleni Kaditi ◽  
Stergios Pispas ◽  
...  
Keyword(s):  
Block Copolymer ◽  
Ethylene Oxide ◽  
Amphiphilic Block Copolymer ◽  
Block Copolymer Micelles ◽  
Copolymer Micelles
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