scholarly journals Small-molecule Nucleic-acid-based Gene-silencing Strategies

10.5772/62137 ◽  
2016 ◽  
Author(s):  
Zhijie Xu ◽  
Lifang Yang
Keyword(s):  
Nucleic Acid ◽  
Gene Silencing ◽  
Small Molecule

scholarly journals Cationic liposome–nucleic acid complexes for gene delivery and gene silencing

2014 ◽  
Vol 38 (11) ◽  
pp. 5164-5172 ◽  
Author(s):  
Cyrus R. Safinya ◽  
Kai K. Ewert ◽  
Ramsey N. Majzoub ◽  
Cecília Leal
Keyword(s):  
Nucleic Acid ◽  
Gene Delivery ◽  
Gene Silencing ◽  
Cationic Liposome

Carbohydrate biomarker recognition using synthetic lectin mimics

2012 ◽  
Vol 84 (11) ◽  
pp. 2479-2498 ◽  
Author(s):  
Chaofeng Dai ◽  
Arpana Sagwal ◽  
Yunfeng Cheng ◽  
Hanjing Peng ◽  
Weixuan Chen ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Small Molecule ◽  
Targeted Delivery ◽  
Boronic Acid ◽  
Peptide Nucleic Acid ◽  
Therapeutic Agents ◽  
Imaging Agents ◽  
Great Promise ◽  
Wide Range ◽  
Tremendous Amount

Carbohydrate biomarkers play very important roles in a wide range of biological and pathological processes. Compounds that can specifically recognize a carbohydrate biomarker are useful for targeted delivery of imaging agents and for development of new diagnostics. Furthermore, such compounds could also be candidates for the development of therapeutic agents. A tremendous amount of active work on synthetic lectin mimics has been reported in recent years. Amongst all the synthetic lectins, boronic-acid-based lectins (boronolectins) have shown great promise. Along this line, four classes of boronolectins including peptide-, nucleic-acid-, polymer-, and small-molecule-based ones are discussed with a focus on the design principles and recent advances. We hope that by presenting the potentials of this field, this review will stimulate more research in this area.

scholarly journals Nucleic Acid Drugs—Current Status, Issues, and Expectations for Exosomes

Cancers ◽  
2021 ◽  
Vol 13 (19) ◽  
pp. 5002
Author(s):  
Yoji Yamada
Keyword(s):  
Nucleic Acid ◽  
Small Molecule ◽  
Viral Infections ◽  
Genetic Disorders ◽  
Clinical Status ◽  
Lipid Nanoparticles ◽  
Current Status ◽  
Nucleic Acid Therapeutics ◽  
Therapeutic Modalities ◽  
Novel Therapeutic

Nucleic acid drugs are being developed as novel therapeutic modalities. They have great potential to treat human diseases such as cancers, viral infections, and genetic disorders due to unique characteristics that make it possible to approach undruggable targets using classical small molecule or protein/antibody-based biologics. In this review, I describe the advantages, classification, and clinical status of nucleic acid therapeutics. To date, more than 10 products have been launched, and many products have been tested in clinics. To promote the use of nucleic acid therapeutics such as antibodies, several hurdles need to be surmounted. The most important issue is the delivery of nucleic acids and several other challenges have been reported. Recent advanced delivery platforms are lipid nanoparticles and ligand conjugation approaches. With the progress of exosome biology, exosomes are expected to contribute to the solution of various problems associated with nucleic acid drugs.

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