scholarly journals Peritonectomy Procedures and HIPEC for Peritoneal Metastasis from Ovarian Cancer

10.5772/60844 ◽  
2016 ◽  
Author(s):  
Angelo Di Giorgio ◽  
Daniele Biacchi ◽  
Antonio Ciardi ◽  
Alessio Impagnatiello ◽  
Maurizio Cardi ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Peritoneal Metastasis ◽  
Peritonectomy Procedures

scholarly journals LncRNA SPOCD1-AS from ovarian cancer extracellular vesicles remodels mesothelial cells to promote peritoneal metastasis via interacting with G3BP1

2021 ◽  
Vol 40 (1) ◽  
Author(s):  
Conghui Wang ◽  
Jiaying Wang ◽  
Xiameng Shen ◽  
Mingyue Li ◽  
Yongfang Yue ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Extracellular Vesicles ◽  
Peritoneal Metastasis ◽  
Cancer Metastasis ◽  
Cancer Therapeutics ◽  
Mesothelial Cells ◽  
Ovarian Cancer Cells ◽  
Adhesion Assay ◽  
Mesenchymal Transition

Abstract Background Metastasis is the key cause of death in ovarian cancer patients. To figure out the biological nature of cancer metastasis is essential for developing effective targeted therapy. Here we investigate how long non-coding RNA (lncRNA) SPOCD1-AS from ovarian cancer extracellular vesicles (EVs) remodel mesothelial cells through a mesothelial-to-mesenchymal transition (MMT) manner and facilitate peritoneal metastasis. Methods EVs purified from ovarian cancer cells and ascites of patients were applied to mesothelial cells. The MMT process of mesothelial cells was assessed by morphology observation, western blot analysis, migration assay and adhesion assay. Altered lncRNAs of EV-treated mesothelial cells were screened by RNA sequencing and identified by qRT-PCR. SPOCD1-AS was overexpressed or silenced by overexpression lentivirus or shRNA, respectively. RNA pull-down and RNA immunoprecipitation assays were conducted to reveal the mechanism by which SPOCD1-AS remodeled mesothelial cells. Interfering peptides were synthesized and applied. Ovarian cancer orthotopic implantation mouse model was established in vivo. Results We found that ovarian cancer-secreted EVs could be taken into recipient mesothelial cells, induce the MMT phenotype and enhance cancer cell adhesion to mesothelial cells. Furthermore, SPOCD1-AS embedded in ovarian cancer-secreted EVs was transmitted to mesothelial cells to induce the MMT process and facilitate peritoneal colonization in vitro and in vivo. SPOCD1-AS induced the MMT process of mesothelial cells via interacting with G3BP1 protein. Additionally, G3BP1 interfering peptide based on the F380/F382 residues was able to block SPOCD1-AS/G3BP1 interaction, inhibit the MMT phenotype of mesothelial cells, and diminish peritoneal metastasis in vivo. Conclusions Our findings elucidate the mechanism associated with EVs and their cargos in ovarian cancer peritoneal metastasis and may provide a potential approach for metastatic ovarian cancer therapeutics.

scholarly journals E-Cadherin fragments as potential mediators for peritoneal metastasis in advanced epithelial ovarian cancer

2016 ◽  
Vol 114 (2) ◽  
pp. 213-220 ◽  
Author(s):  
Fabian Trillsch ◽  
Sascha Kuerti ◽  
Christine Eulenburg ◽  
Eike Burandt ◽  
Linn Woelber ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Peritoneal Metastasis ◽  
Advanced Epithelial Ovarian Cancer ◽  
E Cadherin

scholarly journals The Clinical Desire for Pressurized Intraperitoneal Aerosol Chemotherapy in South Korea: An Electronic Survey-based Study

2021 ◽  
Author(s):  
Eun Ji Lee ◽  
Soo Jin Park ◽  
Jaehee Mun ◽  
Haerin Paik ◽  
Jeesun Lee ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
South Korea ◽  
Pseudomyxoma Peritonei ◽  
Peritoneal Metastasis ◽  
Surgical Complications ◽  
Palliative Treatment ◽  
Online Survey ◽  
Electronic Survey ◽  
Reasonable Cost ◽  
The Many

Abstract Background: Pressurized intraperitoneal aerosol chemotherapy (PIPAC) is effective for treating peritoneal metastasis. However, it is currently used in the limited areas. Thus, we performed a survey to evaluate the clinical desire for PIPAC in South Korea, one of the many countries where PIPAC has not yet been introduced.Methods: We performed an online survey between November and December 2019. The questionnaire consisted of 20 questions, which were divided into comprehensive, procedure, and cost inquiries including five, 13 and two questions, respectively. Results: A total of 164 respondents who answered the questionnaire. Among respondents, 41.7-50% majoring in ovarian cancer, pseudomyxoma peritonei, and malignant mesothelioma preferred PIPAC for the curative treatment of primary diseases, whereas 32.7-33.3% majoring in colorectal and hepatobiliary cancers chose it for the palliative treatment of recurrent diseases. Moreover, 66.7-95.2% considered PIPAC appropriate for the cancers the specialized in, and 76-78.7% expected a treatment response of more than 50% and considered grade 1 or 2 minor surgical complications acceptable. Finally, most of the respondents answered the reasonable costs to purchase and implement PIPAC once at between 1,000,000-5,000,000 KRW. Conclusions: This surgery may reflect on the availability, scope, and reasonable cost of PIPAC treatment in South Korea for introducing PIPAC.

scholarly journals Vascular Cell Adhesion Molecule-1 Is a Regulator of Ovarian Cancer Peritoneal Metastasis

2009 ◽  
Vol 69 (4) ◽  
pp. 1469-1476 ◽  
Author(s):  
Jill K. Slack-Davis ◽  
Kristen A. Atkins ◽  
Christine Harrer ◽  
E. Daniel Hershey ◽  
Mark Conaway
Keyword(s):  
Ovarian Cancer ◽  
Cell Adhesion ◽  
Adhesion Molecule ◽  
Peritoneal Metastasis ◽  
Cell Adhesion Molecule ◽  
Vascular Cell Adhesion ◽  
Vascular Cell ◽  
Vascular Cell Adhesion Molecule ◽  
Cell Adhesion Molecule 1

Abstract 1566: A cancer-stroma-cancer interacting loop promotes peritoneal metastasis of ovarian cancer through TNFα-TGFα-EGFR

2016 ◽  
Author(s):  
Tat-San Lau ◽  
Loucia Kit-Ying Chan ◽  
Chi-Hang Wong ◽  
Chi-Wai Man ◽  
Tak-Hong Cheung ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Peritoneal Metastasis ◽  
Cancer Stroma

Intraperitoneal Treatment With Plasma-Activated Liquid Inhibits Peritoneal Metastasis In Ovarian Cancer Mouse Model

2018 ◽  
Vol 9 ◽  
pp. 47-48 ◽  
Author(s):  
Kae Nakamura ◽  
Hiroaki Kajiyama ◽  
Yang Peng ◽  
Fumi Utsumi ◽  
Nobuhisa Yoshikawa ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Mouse Model ◽  
Peritoneal Metastasis ◽  
Intraperitoneal Treatment
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