scholarly journals Oral Squamous Cell Carcinoma in Young Population — Risk Factors, Clinical Presentation, and Prognosis

Author(s):  
Ligia Buloto Schmidt ◽  
Kellen Cristine Tjioe ◽  
Agnes Assao ◽  
Denise Tostes Oliveira
2020 ◽  
Vol 40 (12) ◽  
pp. 6987-6995
Author(s):  
NORBERT NECKEL ◽  
MARCO MICHAEL ◽  
DANIEL TROELTZSCH ◽  
JONAS WÜSTER ◽  
STEFFEN KOERDT ◽  
...  

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Hirofumi Tomioka ◽  
Yuko Yamagata ◽  
Yu Oikawa ◽  
Toshimitsu Ohsako ◽  
Takuma Kugimoto ◽  
...  

AbstractThe control of distant metastasis in oral squamous cell carcinoma is an important determinant of improved prognosis. The study aimed to identify risk factors for distant metastasis in patients with locoregionally controlled oral carcinoma. We identified 982 patients with oral squamous cell carcinoma treated at our hospital between January 2008 and December 2017. After excluding patients with distant metastasis at initial treatment, patients with metastasis to the oral cavity, those receiving palliative treatment, and those lacking follow-up data, 941 patients were selected. Finally, among these 941 patients, 887 with locoregionally controlled oral squamous cell carcinoma were included in the study. Among the 887 patients, 36 had confirmed distant metastasis (4.1%), and the lung was the most common site (31/36 patients, 86.1%). Multivariate analysis showed that the incidence of primary intraosseous carcinoma of the mandible, cervical lymph node metastasis at levels IV and V, and the presence of pathological extranodal extension were significant risk factors for distant metastasis. When treating patients with oral squamous cell carcinoma who are positive for the aforementioned risk factors, the possibility of developing distant metastases must be accounted for, and aggressive treatment should be planned accordingly.


2012 ◽  
Vol 6 (2) ◽  
pp. 21 ◽  
Author(s):  
Rashmi Metgud ◽  
Madhusudan Astekar ◽  
Meenal Verma ◽  
Ashish Sharma

The etiology of oral squamous cell carcinoma (OSCC) is complex and involves many factors. The most clearly defined risk factors are smoking and alcohol, which substantially increase the risk of oral SCC. However, despite this clear association, a substantial proportion of patients develop OSCC without exposure to them, emphasizing the role of other risk factors such as genetic susceptibility and oncogenic viruses. Some viruses are strongly associated with OSCC while the association of others is less frequent and may depend on co-factors for their carcinogenic effects. Therefore, the exact role of viruses must be evaluated with care in order to improve the diagnosis and treatment of OSCC.


Head & Neck ◽  
2019 ◽  
Vol 41 (7) ◽  
pp. 2093-2099 ◽  
Author(s):  
Shihao Li ◽  
Zixian Huang ◽  
Weiliang Chen ◽  
Chaobin Pan ◽  
Zhiquan Huang

Author(s):  
Lucien Ferndale ◽  
Colleen Aldous ◽  
Richard Hift ◽  
Sandie Thomson

(1) Oesophageal squamous cell carcinoma is common in Africa and has a male preponderance. The gender-based differences in clinical presentation and risk factor exposure are poorly studied in the African context. Our aim was to compare males and females with this disease. We analyzed the differences in clinical features and risk factor exposure between males and females with oesophageal cancer. (2) Data from patients presenting to a tertiary hospital in South Africa with oesophageal squamous cell carcinoma were analyzed. Data collected included patient demographics, clinical presentation, pathology and risk factor exposure. (3) Three hundred and sixty three patients were included in the study. The male to female ratio was 1.4:1. The mean age was 66 years for females and 61 years for males (p < 0.0001). A significantly larger percentage of males were underweight compared to females (60% vs. 32%, p < 0.001). There were no differences between the genders with regards to performance status, dysphagia grade and duration and tumor length, location and degree of differentiation. There were significant differences between risk factor exposure between the two genders. Smoking and alcohol consumption was an association in more than 70% of males but in less than 10% of females There was no difference survival. (4) Female patients with oesophageal squamous cell carcinoma (OSCC) are older and have a higher body mass index (BMI) than their male counterparts. Traditionally purported risk factors of smoking and alcohol consumption are infrequent associations with OSCC in female patients and other environmental risk factors may be more relevant in this gender.


2018 ◽  
Vol 8 (1) ◽  
pp. 29-35
Author(s):  
Md Abdul Hannan ◽  
Mohammad Asifur Rahman ◽  
Shakhawat Hossain ◽  
Quazi Billur Rahman

Squamous cell carcinoma is the most common oral malignancy. Betel quid, betel quid with tobacco, smoking, alcohol consumption, mechanical irritation, genetic are the most important risk factors for Oral Squamous Cell Carcinoma (OSCC). The aim of the study was to determine the role of habitual risk factors inOral Squamous Cell Carcinoma.  Materials and Methods: This is a cross-sectional study for the determination of the risk factors of OSCC over 2 years period of January 2011 to December 2012. Department of Oral & Maxillofacial Surgery, Bangabandhu Sheikh Mujib Medical University, Dhaka, Department of Oral & Maxillofacial Surgery, Dhaka Dental College Hospital, Dhaka,National Institute of Cancer Research & Hospital (NICRH), Mohakhali, Dhaka and Health and Hope Hospital, Dhaka from January 2011 to December 2012  Results:250 patients, comprising 44% male and 56% female were included in the study. Overall mean age was 55.94±10.93 years. The patients of OSCChavemost common habit of betel quid with tobacco 124(49.6%), then betel quid with tobacco and smoking 49(19.6%), betel quid with tobacco and Gul 19(7.6%), only smoking 13(5.2%), Betel quid without tobacco and smoking 13(5.2%), betel quid without tobacco 12(5.2%), betel quid with tobacco and catechu (Khoir) 4(1.6%), betel quid with tobac- co, smoking and gul 3(1.2%), betel quid without tobacco,smoking and alcohol 2(0.8%), betel quid without tobacco and gul 2(0.8%), betel quid without tobacco, smoking and gul 1(0.4%), betel nut chewing 1(0.4%), mechanical irritation but no habit 5(2.0%) and no habitual history 2(0.8%).  Conclusion: According to this study betel quid, betel quid with tobacco, gul, smoking are the important risk factors in OSCC.Update Dent. Coll. j: 2018; 8 (1): 29-35


2012 ◽  
Vol 41 (10) ◽  
pp. 1195-1200 ◽  
Author(s):  
S. Yanamoto ◽  
S. Yamada ◽  
H. Takahashi ◽  
I. Yoshitomi ◽  
G. Kawasaki ◽  
...  

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