scholarly journals Spherical Crystallization of Drugs

10.5772/59627 ◽  
2015 ◽  
Author(s):  
Yousef Javadzadeh ◽  
Zhila Vazifehasl ◽  
Solmaz Maleki Dizaj ◽  
Masumeh Mokhtarpour
Keyword(s):  
Spherical Crystallization

An Overview of Optimization of Spherical Crystallisation Process

2013 ◽  
Vol 6 (4) ◽  
pp. 2203-2209
Author(s):  
N B Bhagat ◽  
A V Yadav ◽  
P R Mastud ◽  
R A Khutale
Keyword(s):  
Physical Phenomenon ◽  
Chemical Properties ◽  
Spherical Shape ◽  
Particle Engineering ◽  
Spherical Crystallization ◽  
Stirring Rate ◽  
Physico Chemical ◽  
Rate Selection ◽  
Pharmaceutical Agents ◽  
Spherical Crystals

In this article we describe the optimizing parameters in the process of spherical crystallisation. Particle engineering of active pharmaceutical agents is an innovative area of research in pharmaceutical industry because of several advantages. Spherical crystallization is one of the particle engineering technique in which drug directly gets crystallized and agglomerated into spherical shape. The spherical crystals can be obtained by different methods like solvent change, Quasi-emulsion droplet, ammonia diffusion and neutralisation. The optimization of process of spherical crystallization is important for obtaining the ideal spherical crystal agglomerates. It includes stirring rate, selection of solvent, pH, temperature etc. which affects on the physico-chemical properties of crystals. These optimizing parameters play its specific role in formation of spherical crystals. Stirring rate affects the shape as well as size of the final agglomerates and solvent selection helps in the formation of maximum amount of agglomerates in the system. The factors like pH and temperature should be maintained in case of drugs which show polymorphism. Apart from this, several others physical phenomenon or parameters like interfacial tension and rate of crystallisation are also important for thorough optimization of process.  

Process Intensification through Continuous Spherical Crystallization Using an Oscillatory Flow Baffled Crystallizer

2017 ◽  
Vol 17 (9) ◽  
pp. 4776-4784 ◽  
Author(s):  
Ramon Peña ◽  
Joseph A. Oliva ◽  
Christopher L. Burcham ◽  
Daniel J. Jarmer ◽  
Zoltan K. Nagy
Keyword(s):  
Oscillatory Flow ◽  
Process Intensification ◽  
Spherical Crystallization

scholarly journals Control of the crystal form by the spherical crystallization technique. Factors causing polymorphism of tolbutamide spherical agglomerates.

1991 ◽  
Vol 28 (3) ◽  
pp. 172-176
Author(s):  
Akimitsu SANO ◽  
Takeo KURIKI ◽  
Yoshiaki KAWASHIMA ◽  
Hirofumi TAKEUCHI ◽  
Tomoaki HINO ◽  
...  
Keyword(s):  
Crystal Form ◽  
Spherical Crystallization ◽  
Spherical Agglomerates

Droplet-Templated Antisolvent Spherical Crystallization of Hydrophilic and Hydrophobic Drugs with an in situ Formed Binder

2017 ◽  
Vol 7 (3) ◽  
pp. 1700797 ◽  
Author(s):  
Tonghan Gu ◽  
Eunice W. Q. Yeap ◽  
Zheng Cao ◽  
Denise Z. L. Ng ◽  
Yinying Ren ◽  
...  
Keyword(s):  
Hydrophobic Drugs ◽  
Spherical Crystallization

Enhanced dissolution rate of simvastatin using spherical crystallization technique

2010 ◽  
Vol 16 (5) ◽  
pp. 529-535 ◽  
Author(s):  
Jaleh Varshosaz ◽  
Naser Tavakoli ◽  
Fatemeh Akhavan Salamat
Keyword(s):  
Dissolution Rate ◽  
Enhanced Dissolution ◽  
Spherical Crystallization

Spherical Crystallization of Glycine from Monodisperse Microfluidic Emulsions

2012 ◽  
Vol 12 (8) ◽  
pp. 3977-3982 ◽  
Author(s):  
Arpad I. Toldy ◽  
Abu Zayed M. Badruddoza ◽  
Lu Zheng ◽  
T. Alan Hatton ◽  
Rudiyanto Gunawan ◽  
...  
Keyword(s):  
Spherical Crystallization
Sign in / Sign up

Export Citation Format

Share Document