scholarly journals Hydrophilic Matrix Tablets Based on Carbopol for Improving the Oral Bioavailability of Sodium Alendronate — In vitro and In vivo Assessment

10.5772/59510 ◽  
2015 ◽  
Author(s):  
Lacramioara Ochiuz ◽  
Anca Giorgiana Grigoras ◽  
Cristina Mihaela Ghiciuc
Keyword(s):  
Oral Bioavailability ◽  
Matrix Tablets ◽  
Hydrophilic Matrix ◽  
In Vivo Assessment

Sustained-release hydrophilic matrix tablets of zileuton: formulation and in vitro/in vivo studies

1997 ◽  
Vol 45 (3) ◽  
pp. 249-256 ◽  
Author(s):  
Yihong Qiu ◽  
Howard Cheskin ◽  
Jackie Briskin ◽  
Kevin Engh
Keyword(s):  
Sustained Release ◽  
Matrix Tablets ◽  
In Vivo Studies ◽  
Hydrophilic Matrix

scholarly journals IVIVC for Extended Release Hydrophilic Matrix Tablets in Consideration of Biorelevant Mechanical Stress

2020 ◽  
Vol 37 (11) ◽  
Author(s):  
Valentyn Mohylyuk ◽  
Seyedreza Goldoozian ◽  
Gavin P. Andrews ◽  
Andriy Dashevskiy
Keyword(s):  
Mechanical Stress ◽  
Special Problem ◽  
Matrix Tablets ◽  
Oral Dosage ◽  
Gi Tract ◽  
Hydrophilic Matrix ◽  
Single Stress ◽  
Oral Dosage Forms

Abstract Purpose When establishing IVIVC, a special problem arises by interpretation of averaged in vivo profiles insight of considerable individual variations in term of time and number of mechanical stress events in GI-tract. The objective of the study was to investigate and forecast the effect of mechanical stress on in vivo behavior in human of hydrophilic matrix tablets. Methods Dissolution profiles for the marketed products were obtained at different conditions (stirring speed, single- or repeatable mechanical stress applied) and convoluted into C-t profiles. Vice versa, published in vivo C-t profiles of the products were deconvoluted into absorption profiles and compared with dissolution profiles by similarity factor. Results Investigated hydrophilic matrix tablets varied in term of their resistance against hydrodynamic stress or single stress during the dissolution. Different scenarios, including repeatable mechanical stress, were investigated on mostly prone Seroquel® XR 50 mg. None of the particular scenarios fits to the published in vivo C-t profile of Seroquel® XR 50 mg representing, however, the average of individual profiles related to scenarios differing by number, frequency and time of contraction stress. When different scenarios were combined in different proportions, the profiles became closer to the original in vivo profile including a burst between 4 and 5 h, probably, due to stress-events in GI-tract. Conclusion For establishing IVIVC of oral dosage forms susceptible mechanical stress, a comparison of the deconvoluted individual in vivo profiles with in vitro profiles of different dissolution scenarios can be recommended.

Lipid Architectonics for Superior Oral Bioavailability of Nelfinavir Mesylate: Comparative in vitro and in vivo Assessment

2018 ◽  
Vol 19 (8) ◽  
pp. 3584-3598 ◽  
Author(s):  
Tejashree Belubbi ◽  
Sukhada Shevade ◽  
Vivek Dhawan ◽  
Vinay Sridhar ◽  
Anuradha Majumdar ◽  
...  
Keyword(s):  
Oral Bioavailability ◽  
Nelfinavir Mesylate ◽  
In Vivo Assessment

scholarly journals Biorelevant In Vitro Release Testing and In Vivo Study of Extended-Release Niacin Hydrophilic Matrix Tablets

2020 ◽  
Vol 21 (3) ◽  
Author(s):  
Bartłomiej Milanowski ◽  
Arkadiusz Hejduk ◽  
Marek A. Bawiec ◽  
Emilia Jakubowska ◽  
Agnieszka Urbańska ◽  
...  
Keyword(s):  
Extended Release ◽  
In Vitro Release ◽  
Matrix Tablets ◽  
In Vivo Study ◽  
Hydrophilic Matrix ◽  
Vitro Release ◽  
Release Testing

The effect of polyion complex formation on in vitro/in vivo correlation of hydrophilic matrix tablets

2003 ◽  
Vol 91 (3) ◽  
pp. 315-326 ◽  
Author(s):  
Yasunori Miyazaki ◽  
Shigeru Yakou ◽  
Tsuneji Nagai ◽  
Kozo Takayama
Keyword(s):  
Complex Formation ◽  
Matrix Tablets ◽  
Hydrophilic Matrix ◽  
Polyion Complex

Preparation and Evaluation of Gemifloxacin Mesylate Floating Matrix Tablets in Healthy Human Volunteers

2017 ◽  
Vol 10 (1) ◽  
pp. 3623-3630
Author(s):  
Bhikshapathi D. V. R. N. ◽  
Haarika B ◽  
Jyothi Sri S ◽  
K Abbulu
Keyword(s):  
Drug Release ◽  
Sodium Bicarbonate ◽  
Polymer Concentration ◽  
Hydroxypropyl Methylcellulose ◽  
Matrix Tablets ◽  
Physical Parameters ◽  
Drug Bioavailability ◽  
Floating Tablets

The purpose of present investigation was to develop floating matrix tablets of gemifloxacin mesylate, which after oral administration could prolong the gastric residence time, increase the drug bioavailability and diminish the side effects of irritating drugs. Tablets containing drug, various viscosity grades of hydroxypropyl methylcellulose such as HPMC K4M and HPMC K15M as matrix forming agent, Sodium bicarbonate as gas-forming agent and different additives were tested for their usefulness in formulating gastric floating tablets by direct compression method. The physical parameters, in vitro buoyancy, release characteristics and in vivo radiographic study were investigated in this study. The gemifloxacin mesylate floating tablets were prepared using HPMC K4M polymer giving more sustained drug release than the tablet containing HPMC K15M. All these formulations showed floating lag time of 30 to 47 sec and total floating time more than 12 h. The drug release was decreased when polymer concentration increases and gas generating agent decreases. Formulation that contains maximum concen-tration of both HPMC K15M and sodium bicarbonate (F9) showing sufficiently sustained with 99.2% of drug release at 12 h. The drug release from optimized formulation follows Higuchi model that indicates the diffusion controlled release. The best formulation (F9) was selected based on in vitro characteristics and used in vivo radiographic studies by incorporating barium sulphate as a radio-opaque agent and the tablet remained in the stomach for about 6 h.   

Fenofibrate Solid Dispersion for Improving Oral Bioavailability: Preparation, and Characterization and in vivo Evaluation

2020 ◽  
Vol 13 (5) ◽  
pp. 5102-5109
Author(s):  
Venu Madhav K ◽  
Somnath De ◽  
Chandra Shekar Bonagiri ◽  
Sridhar Babu Gummadi
Keyword(s):  
Oral Bioavailability ◽  
Oral Delivery ◽  
Solid Dispersions ◽  
In Vitro Release ◽  
Aqueous Solubility ◽  
Water Soluble ◽  
Scanning Calorimetry ◽  
In Vivo Evaluation

Fenofibrate (FN) is used in the treatment of hypercholesterolemia. It shows poor dissolution and poor oral bioavailability after oral administration due to high liphophilicity and low aqueous solubility. Hence, solid dispersions (SDs) of FN (FN-SDs) were develop that might enhance the dissolution and subsequently oral bioavailability. FN-SDs were prepared by solvent casting method using different carriers (PEG 4000, PEG 6000, β cyclodextrin and HP β cyclodextrin) in different proportions (0.25%, 0.5%, 0.75% and 1% w/v). FN-SDs were evaluated solubility, assay and in vitro release studies for the optimization of SD formulation. Differential scanning calorimetry (DSC), powder X-ray diffraction (PXRD) and scanning electron microscopy (SEM) analysis was performed for crystalline and morphology analysis, respectively. Further, optimized FN-SD formulation evaluated for pharmacokinetic performance in Wistar rats, in vivo in comparison with FN suspension.  From the results, FN-SD3 and FN-SD6 have showed 102.9 ±1.3% and 105.5±3.1% drug release, respectively in 2 h. DSC and PXRD studies revealed that conversion of crystalline to amorphous nature of FN from FT-SD formulation. SEM studies revealed the change in the orientation of FN when incorporated in SDs. The oral bioavailability FN-SD3 and FN-SD6 formulations exhibited 2.5-folds and 3.1-folds improvement when compared to FN suspension as control. Overall, SD of FN could be considered as an alternative dosage form for the enhancement of oral delivery of poorly water-soluble FN.

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