scholarly journals Non-Invasive Imaging Modalities for Clinical Investigation in Regenerative Medicine

10.5772/59356 ◽  
2014 ◽  
Author(s):  
Deana G. Haralampieva ◽  
Simon M. Ametamey ◽  
Tullio Sulser ◽  
Daniel Eberli
Keyword(s):  
Regenerative Medicine ◽  
Clinical Investigation ◽  
Imaging Modalities ◽  
Non Invasive

scholarly journals Multiplexed Non-invasive in vivo Imaging to Assess Metabolism and Receptor Engagement in Tumor Xenografts

2019 ◽  
Author(s):  
Alena Rudkouskaya ◽  
Nattawut Sinsuebphon ◽  
Marien Ochoa ◽  
Joe E. Mazurkiewicz ◽  
Xavier Intes ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Delivery ◽  
Near Infrared ◽  
Metabolic Response ◽  
Imaging Modalities ◽  
Wide Field ◽  
Receptor Ligand ◽  
Non Invasive ◽  
Intracellular Drug Delivery

AbstractFollowing an ever-increased focus on personalized medicine, there is a continuing need to develop preclinical molecular imaging modalities to guide the development and optimization of targeted therapies. To date, non-invasive quantitative imaging modalities that can comprehensively assess simultaneous cellular drug delivery efficacy and therapeutic response are lacking. In this regard, Near-Infrared (NIR) Macroscopic Fluorescence Lifetime Förster Resonance Energy Transfer (MFLI-FRET) imaging offers a unique method to robustly quantify receptor-ligand engagement in vivo and subsequent intracellular internalization, which is critical to assess the delivery efficacy of targeted therapeutics. However, implementation of multiplexing optical imaging with FRET in vivo is challenging to achieve due to spectral crowding and cross-contamination. Herein, we report on a strategy that relies on a dark quencher that enables simultaneous assessment of receptor-ligand engagement and tumor metabolism in intact live mice. First, we establish that IRDye QC-1 (QC-1) is an effective NIR dark acceptor for the FRET-induced quenching of donor Alexa Fluor 700 (AF700) using in vitro NIR FLI microscopy and in vivo wide-field MFLI imaging. Second, we report on simultaneous in vivo imaging of the metabolic probe IRDye 800CW 2-deoxyglucose (2-DG) and MFLI-FRET imaging of NIR-labeled transferrin FRET pair (Tf-AF700/Tf-QC-1) uptake in tumors. Such multiplexed imaging revealed an inverse relationship between 2-DG uptake and Tf intracellular delivery, suggesting that 2-DG signal may predict the efficacy of intracellular targeted delivery. Overall, our methodology enables for the first time simultaneous non-invasive monitoring of intracellular drug delivery and metabolic response in preclinical studies.

scholarly journals Imaging modalities for the non-invasive diagnosis of endometriosis

2016 ◽  
Author(s):  
Vicki Nisenblat ◽  
Patrick MM Bossuyt ◽  
Cindy Farquhar ◽  
Neil Johnson ◽  
M Louise Hull
Keyword(s):  
Imaging Modalities ◽  
Non Invasive

Future Trends in Intravascular Imaging

2011 ◽  
pp. 350-354
Author(s):  
George D. Giannoglou ◽  
Yiannis S. Chatzizisis
Keyword(s):  
Early Diagnosis ◽  
Potential Application ◽  
Vulnerable Plaque ◽  
Imaging Modalities ◽  
Intravascular Imaging ◽  
Future Trends ◽  
Regional Characteristics ◽  
Non Invasive ◽  
Vulnerable Plaques ◽  
Coronary Events

Vulnerable plaques have certain histopathologic and regional characteristics. The advent of novel invasive and non-invasive imaging modalities aim to identify the histopathologic and regional characteristics of vulnerable plaque, thereby enabling the early diagnosis and potential application of treatments strategies to avert future acute coronary events.

Non-invasive imaging modalities to study neurodegenerative diseases of aging brain

2019 ◽  
Vol 95 ◽  
pp. 54-69
Author(s):  
Ramesh Naidu Annavarapu ◽  
Srujana Kathi ◽  
Vamsi Krishna Vadla
Keyword(s):  
Neurodegenerative Diseases ◽  
Imaging Modalities ◽  
Aging Brain ◽  
Non Invasive

The continually evolving field of surgery

2018 ◽  
Vol 183 (17) ◽  
pp. 546.2-546
Keyword(s):  
Minimally Invasive Surgery ◽  
Soft Tissue ◽  
Regenerative Medicine ◽  
Minimally Invasive ◽  
Invasive Surgery ◽  
Orthopaedic Surgery ◽  
Small Animal ◽  
Imaging Modalities ◽  
Animal Surgery

BVA members can claim an exclusive discount on the latest edition of Small Animal Surgery by Theresa Welch Fossum. Described as ‘the go-to, full-colour guide for everything that general veterinarians and vet students need to know about both soft tissue and orthopaedic surgery’, the new 5th edition discusses the latest advances in key areas such as imaging modalities, regenerative medicine, minimally invasive surgery and neurology

Introduction to nuclear cardiology

2011 ◽  
Author(s):  
Nikant Sabharwal ◽  
Chee Yee Loong ◽  
Andrew Kelion
Keyword(s):  
Nuclear Cardiology ◽  
Cardiac Disease ◽  
Imaging Technique ◽  
First Century ◽  
Imaging Modalities ◽  
Non Invasive ◽  
Early Twenty ◽  
Cardiac Imaging Technique ◽  
Wide Range ◽  
Electrocardiogram Ecg

Introduction 2Important milestones 4Relation to other imaging modalities 6The cardiologist of the early twenty-first century takes for granted the wide range of imaging modalities at his/her disposal, but it was not always so. At the beginning of the 1970s, invasive cardiac catheterization was the only reliable cardiac imaging technique. Subsequently, nuclear cardiology investigations led the way in the non-invasive assessment of cardiac disease. Some of the principles underlying these investigations [e.g. electrocardiogram (ECG)-triggered gating] have also been of great importance in the development of other imaging modalities....

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