scholarly journals The Role of Capsaicin-Sensitive Afferent Nerves in Gastric Mucosal Protection Initiated Centrally or Peripherally under Experimental Conditions

10.5772/58573 ◽  
2014 ◽  
Author(s):  
Klara Gyires
Keyword(s):  
Mucosal Protection ◽  
Experimental Conditions ◽  
Afferent Nerves ◽  
Gastric Mucosal Protection

scholarly journals Role of gap junctions in gastric mucosal protection.

1993 ◽  
Vol 61 ◽  
pp. 107
Author(s):  
Fujsao Ueda ◽  
Kiyotaka Mimura ◽  
Shin-ichi Tsuchiya ◽  
Kiyoshi Kimura
Keyword(s):  
Gap Junctions ◽  
Mucosal Protection ◽  
Gastric Mucosal Protection

The Role of Mucus in Gastric Mucosal Protection against Hydrogen Ion

1986 ◽  
Vol 463 (1 Second Colloq) ◽  
pp. 351-353 ◽  
Author(s):  
B. L. SLOMIANY ◽  
J. SAROSIEK ◽  
A. TAKAGI ◽  
A. SLOMIANY
Keyword(s):  
Hydrogen Ion ◽  
Mucosal Protection ◽  
Gastric Mucosal Protection

scholarly journals The role of cannabinoid CB1 receptor agonists in gastric mucosal protection in rats and mice

2007 ◽  
Vol 7 (Suppl 2) ◽  
pp. A47
Author(s):  
Nashwan Shujaa ◽  
Zoltán S Zádori ◽  
Mahmoud Al-Khrasani ◽  
Susanna Fürst ◽  
Tibor Wenger ◽  
...  
Keyword(s):  
Cb1 Receptor ◽  
Mucosal Protection ◽  
Cannabinoid Cb1 Receptor ◽  
Receptor Agonists ◽  
Gastric Mucosal Protection ◽  
Rats And Mice

Role of capsaicin-sensitive afferent nerves in mucosal injury and injury-induced hyperemia in rat colon

1992 ◽  
Vol 262 (2) ◽  
pp. G332-G337 ◽  
Author(s):  
F. W. Leung
Keyword(s):  
Acetic Acid ◽  
Colonic Mucosa ◽  
Mucosal Injury ◽  
Mucosal Damage ◽  
Rat Colon ◽  
Mucosal Protection ◽  
Reflectance Spectrophotometry ◽  
Afferent Nerves ◽  
Measuring Probe

Exposure of the colonic mucosa to 10% acetic acid results in ischemia and damage of the exposed mucosa and hyperemia in the adjacent unexposed and undamaged mucosa. We hypothesize that this hyperemia is mediated in part by capsaicin-sensitive afferent nerves, and absence of the hyperemia is associated with aggravation of damage in the exposed mucosa. In urethan-anesthetized rats, with the reflectance spectrophotometry probe in contact with the colonic mucosa, index of mucosal oxygen saturation (ISO2) was monitored before and for 5 min after 10% acetic acid was applied to the mucosa surrounding the measuring probe. Histological examination confirmed that the mucosa in contact with the measuring probe was undamaged, but the mucosa exposed to the 10% acetic acid was damaged. In the mucosa in contact with the reflectance spectrophotometry probe, a significant increase in ISO2 was observed in vehicle-pretreated rats, whereas a partial but significant reduction of such hyperemia was observed in capsaicin-pretreated rats. In the mucosa exposed to the 10% acetic acid, the depth of the mucosal lesion, but not the drop in ISO2, was significantly greater in the capsaicin-pretreated rats. The findings are consistent with the hypothesis that the colonic mucosal hyperemia in the undamaged mucosa adjacent to the mucosa damaged by the 10% acetic acid is mediated partially by capsaicin-sensitive afferent nerves. Attenuation of such hyperemia by capsaicin-pretreatment is associated with deeper mucosal damage, suggesting that the capsaicin-sensitive afferent nerves also contribute toward colonic mucosal protection against 10% acetic acid-induced injury in the exposed mucosa.

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