scholarly journals Helicobacter pylori — Current Therapy and Future Therapeutic Strategies

10.5772/58338 ◽  
2014 ◽  
Author(s):  
Rajinikanth Siddalingam ◽  
Kumarappan Chidambaram
Keyword(s):  
Helicobacter Pylori ◽  
Therapeutic Strategies ◽  
Current Therapy

scholarly journals The role of tissue kallikrein in helicobacter pylori-associated gastric disease

1999 ◽  
Author(s):  
◽  
Strinivasen Naidoo
Keyword(s):  
Helicobacter Pylori ◽  
World Wide ◽  
Current Therapy ◽  
Gastric Disease ◽  
Tissue Kallikrein ◽  
Gastric Diseases ◽  
Triple Regimen ◽  
Clinical Conditions ◽  
Wide Population

Today, the number one income-generating drugs are remedies prescribed for gastric disorders, in particular dyspepsia. These clinical conditions have a multi-faceted aetiology and pathology of dysfunction. One likely causal factor is the entero-pathogen Helicobacter pylori. It has been shown to be more than just a commensal related to gastric diseases like dyspepsia (80-90% incidence) and duodenal ulcer sufferers (100% incidence), with a total estimated world-wide population infection of 50%. The current therapy offered to dyspepsia sufferers is a triple regimen of an anti-bacterial, an Ir proton-pump inhibitor, and bismuth colloidal salts.

scholarly journals Analysis and prediction of T and B epitopes in Helicobacter pylori proteins: An initial approach to the rational design of alternative therapeutic strategies without the use of antibiotics

2017 ◽  
Vol 33 (3) ◽  
pp. 477-491
Author(s):  
Elkin Navarro-Quiroz ◽  
◽  
Roberto Navarro-Quiroz ◽  
Pierine España-Puccin ◽  
Mostapha Ahmad ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Rational Design ◽  
Therapeutic Strategies ◽  
Initial Approach

scholarly journals DRUG RESISTANCE IN HELICOBACTER PYLORI

2016 ◽  
Vol 53 (4) ◽  
pp. 215-223 ◽  
Author(s):  
Júlia Silveira VIANNA ◽  
Ivy Bastos RAMIS ◽  
Daniela Fernandes RAMOS ◽  
Andrea VON GROLL ◽  
Pedro Eduardo Almeida da SILVA
Keyword(s):  
Helicobacter Pylori ◽  
Digestive System ◽  
Point Mutations ◽  
Resistance Mechanisms ◽  
High Rate ◽  
Current Therapy ◽  
Genetic Characteristics ◽  
Inappropriate Use ◽  
Worldwide Distribution ◽  
H Pylori

ABSTRACT Background Helicobacter pylori has a worldwide distribution and is associated with the pathogenesis of various diseases of the digestive system. Treatment to eradicate this microorganism involves the use of a combination of antimicrobials, such as amoxicillin, metronidazole, clarithromycin, and levofloxacin, combined with proton pump inhibitors. Although the current therapy is effective, a high rate of treatment failure has been observed, mainly because of the acquisition of point mutations, one of the major resistance mechanisms developed by H. pylori. This phenomenon is related to frequent and/or inappropriate use of antibiotics. Conclusion This review reported an overview of the resistance to the main drugs used in the treatment of H. pylori, confirming the hypothesis that antibacterial resistance is a highly local phenomenon and genetic characteristics of a given population can influence which therapy is the most appropriate.

scholarly journals Effectiveness ofCitrusFruits onHelicobacter pylori

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Giuseppina Mandalari ◽  
Carlo Bisignano ◽  
Santa Cirmi ◽  
Michele Navarra
Keyword(s):  
Helicobacter Pylori ◽  
Peptic Ulcer ◽  
Side Effects ◽  
Gastric Carcinoma ◽  
Current Knowledge ◽  
Therapeutic Strategies ◽  
Treatment Regimens ◽  
H Pylori ◽  
Novel Therapeutic Strategies ◽  
Novel Therapeutic

It is known thatHelicobacter pyloriinfection is associated with chronic gastritis, peptic ulcer, and gastric carcinoma. Due to the increased side effects of the treatment regimens and the development of antimicrobial resistance, a number of natural compounds have been tested as potential alternatives. In this review, we will examine the current knowledge on the effect ofCitrusfruits and their derivatives againstH. pylori, highlighting the remaining outstanding questions on the development of novel therapeutic strategies.

scholarly journals Current Therapy forHelicobacter pyloriInfection in Children and Adolescents

1999 ◽  
Vol 13 (7) ◽  
pp. 571-579 ◽  
Author(s):  
Benjamin D Gold
Keyword(s):  
Health Care ◽  
Helicobacter Pylori ◽  
Consensus Conference ◽  
Gastric Ulcers ◽  
Current Therapy ◽  
Consensus Conferences ◽  
Gastroduodenal Disease ◽  
Practical Guidelines ◽  
H Pylori

Helicobacter pyloriinfects approximately 50% of the world’s population and is a definitive cause of gastroduodenal disease (ie, gastritis, duodenal and gastric ulcers) in children and adults. Four consensus conferences held around the globe have brought together clinicians, scientists, epidemiologists and health care economists to discuss the role of the gastric pathogenH pyloriin human gastroduodenal disease. At each of these conferences, the overriding objective was to reach a consensus on the development of practical guidelines for the diagnosis and treatment ofH pylori-infected individuals. However, it was not until the CanadianH pyloriConsensus Conference, held in November 1997, that the issues ofH pyloriinfection in children were addressed. Therapies forH pyloriinfection in children, presented in part at the First Canadian PaediatricH pyloriConsensus Conference, held in Victoria, British Columbia, November 1998, are reviewed in this paper.

scholarly journals Article Commentary: Molecular Targets of Breast Cancer: AKTing in Concert

2008 ◽  
Vol 2 ◽  
pp. BCBCR.S787
Author(s):  
Alakananda Basu
Keyword(s):  
Breast Cancer ◽  
Signaling Pathways ◽  
Tumor Suppressor Genes ◽  
Poor Prognosis ◽  
Recent Literature ◽  
Molecular Targets ◽  
Akt Signaling ◽  
Therapeutic Strategies ◽  
Current Therapy ◽  
Akt Signaling Pathway

Despite significant advancement in the diagnosis and treatment of breast cancer, many patients succumb to this disease. The elucidation of aberrant signaling pathways that lead to breast cancer should help develop more effective therapeutic strategies. The Akt signaling pathway plays an important role in the development and progression of breast cancer. Overexpression/activation of Akt has been associated with poor prognosis and resistance to hormonal and chemotherapy. Although mutations in Akt are rare in breast cancer, the activity of Akt is regulated by hormones, growth factors, growth factor receptors, oncogenes and tumor suppressor genes that are often deregulated in breast cancer. The objective of this commentary is to discuss recent literature on how activation of Akt by various signaling pathways contributes to breast cancer and confers resistance to current therapy.

The rod-to-coccoid body transformation in cultures of Helicobacter pylori

1990 ◽  
Vol 48 (3) ◽  
pp. 626-627
Author(s):  
A. R. Crooker ◽  
W. G. Kraft ◽  
T. L. Beard ◽  
M. C. Myers
Keyword(s):  
Helicobacter Pylori ◽  
Growth Cycle ◽  
Negative Bacterium ◽  
Body Formation ◽  
Coccoid Form ◽  
Spiral Form ◽  
Prolonged Culture ◽  
H Pylori ◽  
Upper Gastrointestinal

Helicobacter pylori is a microaerophilic, gram-negative bacterium found in the upper gastrointestinal tract of humans. There is strong evidence that H. pylori is important in the etiology of gastritis; the bacterium may also be a major predisposing cause of peptic ulceration. On the gastric mucosa, the organism exists as a spiral form with one to seven sheathed flagella at one (usually) or both poles. Short spirals were seen in the first successful culture of the organism in 1983. In 1984, Marshall and Warren reported a coccoid form in older cultures. Since that time, other workers have observed rod and coccal forms in vitro; coccoid forms predominate in cultures 3-7 days old. We sought to examine the growth cycle of H. pylori in prolonged culture and the mode of coccoid body formation.

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