scholarly journals Alterations in TP53 gene – Implications in Tumorigenesis Process and Prognosis in Central Nervous System Cancer

10.5772/58334 ◽  
2014 ◽  
Author(s):  
Igor Andrade Pessôa ◽  
Fabio P. Estumano da Silva ◽  
Nilson Praia Anselmo ◽  
Edivaldo Herculano C. de Oliveira
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Tp53 Gene ◽  
Central Nervous System Cancer ◽  
Nervous System Cancer

Disability-Adjusted Life Years and Mortality Rate Attributed to Brain and Central Nervous System Cancer in the Middle East and North Africa Countries

2021 ◽  
pp. 1-13
Author(s):  
Hamid Reza Saeidi Borojeni ◽  
Farid Najafi ◽  
Fatemeh Khosravi Shadmani ◽  
Zahra Darabi ◽  
Mitra Darbandi ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Mortality Rate ◽  
North Africa ◽  
Disability Adjusted Life Years ◽  
Mena Region ◽  
Central Nervous System Cancer ◽  
Disability Adjusted Life ◽  
Life Years ◽  
Nervous System Cancer

<b><i>Background:</i></b> Primary brain tumors are among the main causes of death. This study aimed to determine the epidemiological features of the brain and central nervous system cancer in the Middle East and North Africa (MENA) region. <b><i>Methods:</i></b> In this study, data of the Global Burden of Disease (GBD) study were used to estimate the incidence, prevalence, deaths, disability-adjusted life years (DALYs), and mortality in 21 countries in the MENA region from 1990 to 2019 based on age and sex. The percentage of the changes of epidemiologic indicators was calculated between 1990 and 2019. <b><i>Results:</i></b> Palestine and Turkey had the highest rate of brain and central nervous system cancer in 2019. Saudi Arabia, Oman, Iraq, and Lebanon had the highest percentage of incidence rate changes from 1990 to 2019. The prevalence of brain and central nervous system cancer in the MENA region was increased from 7.51 (95% CI: 4.95–11.01) in 1990 to 16.45 (95% CI: 10.83–19.54) in 2019 (percentage of changes = 54.35%). The standardized age mortality rate in the MENA region was increased by 2.7% in 2019 compared to that in 1990. The rate of standardized age of DALY per 100,000 individuals in the MENA region decreased from 135.09 (95% CI: 92.57–199.92) in 1990 to 128.34 (95% CI: 87.81–151.3) in 2019. <b><i>Conclusion:</i></b> The incidence rate, prevalence, and standardized age mortality (per 100,000) had increased significantly in the MENA region in 2019 compared to those in 1990. Focusing on the diversity of the estimates of such indices in different countries of MENA can lead to the identification of important risk factors for brain cancer in future studies.

Case–control study of brain and other central nervous system cancer among workers at semiconductor and storage device manufacturing facilities

2020 ◽  
Vol 77 (4) ◽  
pp. 238-248 ◽  
Author(s):  
Ema G Rodrigues ◽  
Robert F Herrick ◽  
James Stewart ◽  
Helena Palacios ◽  
Francine Laden ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Case Control Study ◽  
Case Control ◽  
Cumulative Exposure ◽  
Storage Device ◽  
Central Nervous System Cancer ◽  
Cns Cancer ◽  
Control Study ◽  
Nervous System Cancer

ObjectiveThis study evaluated the relationship between brain and other central nervous system cancer (‘CNS cancer’) and exposures at two semiconductor and electronic module manufacturing facilities and at a storage device manufacturing facility.MethodsThe case–control study, nested in a cohort of 126 836 employees, compared 120 CNS cancer cases and 1028 matched controls with respect to employment in 10 process groups and estimated cumulative exposure to 31 known or possible carcinogens.ResultsCNS cancer was associated with module manufacturing operations at two facilities. Module manufacturing is a process that begins with production of ceramic substrates followed by attachment of completed semiconductor chips and metal-containing circuitry resulting in a high performing electronic device. Positive associations with the highest tertile of estimated cumulative exposure were found for several chemicals, including 2-butoxyethanol, cyclohexanone, ortho-dichlorobenzene, cadmium, molybdenum, trichloroethylene and vinyl chloride.ConclusionsResults suggested positive associations between CNS cancer and specific operations and chemicals experienced in the semiconductor and electronic module manufacturing industry. However, lack of external support for these findings precludes a causal interpretation, and the observed associations may have been due to chance.

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