scholarly journals PET-CT in Anal Cancer: Indications and Limits

10.5772/57121 ◽  
2013 ◽  
Author(s):  
Massimiliano Mistrangelo ◽  
Adriana Lesc
Keyword(s):  
Anal Cancer ◽  
Pet Ct

scholarly journals FDG-PET/CT in the Radiotherapy Treatment Planning of Locally Advanced Anal Cancer: A Monoinstitutional Experience

2021 ◽  
Vol 11 ◽  
Author(s):  
Clelia Di Carlo ◽  
Maika di Benedetto ◽  
Lisa Vicenzi ◽  
Sara Costantini ◽  
Francesca Cucciarelli ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Anal Cancer ◽  
Dose Escalation ◽  
Locally Advanced ◽  
Target Volume ◽  
Target Volume Delineation ◽  
18Fdg Pet ◽  
Volume Delineation ◽  
Pet Ct ◽  
The Impact

AimsRadiotherapy with concurrent 5-fluorouracil/mitomycin-C based chemotherapy has been established as definitive standard therapy approach for anal cancer. Intensity Modulated Radiotherapy (IMRT) leads to a precise treatment of the tumor, allowing dose escalation on Gross Tumor Volume (GTV), with a surrounding healthy tissues sparing. Our study assessed the impact of 18-Fluorodeoxyglucose positron emission tomography (18FDG-PET/CT) on the radiotherapy contouring process and its contribution to lymphatic spread detection, resulting to a personalization of Clinical Target Volume (CTV) and dose prescription.MethodsThirty-seven patients, with histologically proven squamous cell carcinoma of the anal canal (SCCAC) were analyzed. All patients were evaluated with history and physical examination, trans-anal endoscopic ultrasound, pelvis magnetic resonance imaging (MRI), computed tomography (CT) scans of the chest, abdomen and pelvis and planning 18FDG-PET/CT. The GTV and CTV were drawn on CT, MRI and 18FDG-PET/CT fused images.ResultsThirty-four (91%) out of 37 patients presented lymph nodes involvement, in one or more areas, detected on 18FDG-PET/CT and/or MRI. The 18FDG-PET/CT showed positive lymph nodes not detected on MRI imaging (PET+, MRI−) in 14/37 patients (38%). In 14 cases, 18FDG-PET/CT allowed to a dose escalation in the involved nodes. The 18FDG-PET/CT fused images led to change the stage in 5/37(14%) cases: four cases from N0 to N1 (inguinal lymph nodes) and in one case from M0 to M1 (common iliac lymph nodes).ConclusionsThe 18FDG-PET/CT has a potentially relevant impact in staging and target volume delineation/definition in patients affected by anal cancer. In our experience, clinical stage variation occurred in 14% of cases. More investigations are needed to define the role of 18FDG-PET/CT in the target volume delineation of anal cancer.

FDG-PET/CT is Predictive of Progression-free Survival in Anal Cancer

2009 ◽  
Vol 75 (3) ◽  
pp. S258-S259
Author(s):  
W.W. Lien ◽  
A.R. Rao ◽  
J.S. Kaptein ◽  
M.A. Tome
Keyword(s):  
Anal Cancer ◽  
Fdg Pet ◽  
Progression Free Survival ◽  
Free Survival ◽  
Pet Ct ◽  
Fdg Pet Ct

985 poster THE IMPACT OF PET/CT ON RADIOTHERAPY OF ANAL CANCER

2011 ◽  
Vol 99 ◽  
pp. S372
Author(s):  
J. Sveistrup ◽  
A. Loft ◽  
A.K. Berthelsen ◽  
B.M. Henriksen ◽  
S.A. Engelholm
Keyword(s):  
Anal Cancer ◽  
Pet Ct ◽  
The Impact

Diagnostic performance and prognostic role of FDG PET/CT performed at staging in anal cancer

2020 ◽  
Vol 8 (2) ◽  
pp. 55-64
Author(s):  
Lucia Leccisotti ◽  
D. Ripani ◽  
S. Manfrida ◽  
A. Giordano
Keyword(s):  
Anal Cancer ◽  
Fdg Pet ◽  
Diagnostic Performance ◽  
Prognostic Role ◽  
Pet Ct ◽  
Fdg Pet Ct

scholarly journals Additional Value of 2-[18F]FDG PET/CT Comparing to MRI in Treatment Approach of Anal Cancer Patients

2020 ◽  
Vol 9 (9) ◽  
pp. 2715
Author(s):  
Reyhaneh Manafi-Farid ◽  
Alexander Kupferthaler ◽  
Helwig Wundsam ◽  
Georg Gruber ◽  
Reza Vali ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Anal Cancer ◽  
Fdg Pet ◽  
Prognostic Value ◽  
Number Of Patients ◽  
Pet Ct ◽  
18F Fdg ◽  
Pre Treatment ◽  
Fdg Pet Ct ◽  
The Impact

Accurate staging and treatment planning are imperative for precise management in Anal Cancer (ACa) patients. We aimed to evaluate the additive and prognostic value of pre-treatment 2-[18F]fluoro-2-deoxy-d-glucose positron emission tomography/computed tomography (2-[18F]FDG PET/CT) in the staging and management of ACa compared to magnetic resonance imaging (MRI). This retrospective study was conducted on 54 patients. Pre-treatment 2-[18F]FDG PET/CT studies and MRI reports were compared considering the primary tumor, pelvic lymph nodes, and metastatic lesions. The impact of 2-[18F]FDG PET/CT in the management and its prognostic value, using maximum standardized uptake value (SUVmax), were assessed. Discordant findings were found in 46.3% of patients (5 in T; 1 in T and N; 18 in N; and 1 in M stage). 2-[18F]FDG PET/CT resulted in up-staging in 9.26% and down-staging in 3.7% of patients. Perirectal lymph nodes were metabolically inactive in 12.9% of patients. Moreover, 2-[18F]FDG PET/CT resulted in management change in 24.1% of patients. Finally, SUVmax provided no prognostic value. 2-[18F]FDG PET/CT altered staging and management in a sizable number of patients in this study, and supports a need for a change in guidelines for it to be used as a routine complementary test in the initial management of ACa.

Tumor Response and Survival Predicted by Post-Therapy FDG-PET/CT in Anal Cancer

2008 ◽  
Vol 71 (1) ◽  
pp. 180-186 ◽  
Author(s):  
Julie K. Schwarz ◽  
Barry A. Siegel ◽  
Farrokh Dehdashti ◽  
Robert J. Myerson ◽  
James W. Fleshman ◽  
...  
Keyword(s):  
Anal Cancer ◽  
Fdg Pet ◽  
Tumor Response ◽  
Pet Ct ◽  
Fdg Pet Ct ◽  
Post Therapy
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