scholarly journals Association Between Creatinine Clearance and Insulin- Resistance in Healthy Adolescent Boys

10.5772/56483 ◽  
2013 ◽  
Author(s):  
Valeria Hirschler
Keyword(s):  
Insulin Resistance ◽  
Creatinine Clearance ◽  
Adolescent Boys ◽  
Healthy Adolescent

scholarly journals The Effects of Vitamin D Supplementation on Lipid and Inflammatory Profile of Healthy Adolescent Boys: A Randomized Controlled Trial

Nutrients ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 1213
Author(s):  
Amirhossein Yarparvar ◽  
Ibrahim Elmadfa ◽  
Abolghasem Djazayery ◽  
Zahra Abdollahi ◽  
Forouzan Salehi ◽  
...  
Keyword(s):  
Vitamin D ◽  
Lipid Profile ◽  
Controlled Trial ◽  
Group Analysis ◽  
Serum Levels ◽  
Vitamin D Supplementation ◽  
Inflammatory Biomarkers ◽  
Adolescent Boys ◽  
Healthy Adolescent ◽  
School Based

Background: Deficiency of vitamin D, an anti-inflammatory micronutrient with some favorable effects on lipid profiles, has been found to be highly prevalent in adolescents. We aimed to investigate the effect of a school-based vitamin D supplementation regimen on the correction of vitamin D deficiency as well as lipid and inflammatory profiles of healthy adolescent boys. Methods: In this randomized single-blind placebo-controlled trial, seventy-one healthy adolescent boys (age 17 years old) were recruited from one high school in Tehran, Iran, and randomly assigned to two groups. The supplement group received vitamin D pearls at a dose of 50,000 IU monthly for 6 months, this dose is indeed defined by the Ministry of Health in Iran for a potential national school-based vitamin D supplementation program. The other group was given placebo pearls for the same duration. Before and after the treatment, the serum levels of 25-hydroxy vitamin D (25(OH) D), parathyroid hormone (PTH), retinol, lead (Pb), the lipid profile and the inflammatory biomarkers were measured and compared. Results: Between-groups statistical analysis showed that a dose (50,000 IU/month) vitamin D significantly increased the serum levels of 25-hydroxyvitamin D (25 (OH) D) (p < 0.001) and decreased serum levels of PTH (p = 0.003). No significant change was observed in serum levels of retinol and Pb. Between-group analysis revealed that the serum levels of TG (P = 0.001) decreased while an increase in serum levels of HDL (p = 0.021) was observed (p < 0.05). Both the within- and between-group analysis showed that serum tumor necrosis factor receptor 2 (TNFR2) concentration declined while serum interleukin-10 (IL-10) increased in response to vitamin D supplementation (p < 0.05). Conclusion: A supplementation regimen of (50,000 IU/month) vitamin D in a context with high rates of vitamin deficiency has shown positive impacts on the serum vitamin D, lipid profile and inflammatory biomarkers in healthy adolescent boys.

scholarly journals The Effects of Circuit Resistance Training on Inflammatory Status, Insulin Resistance and Body Composition in Overweight Adolescent Boys

2020 ◽  
Author(s):  
Hamid Alizadeh ◽  
Alireza Safarzade ◽  
Elahe Talebi-Garakani
Keyword(s):  
Insulin Resistance ◽  
Body Composition ◽  
Resistance Training ◽  
P Value ◽  
Daily Routine ◽  
Adolescent Boys ◽  
Inflammatory Status ◽  
Overweight Adolescent ◽  
Circuit Resistance Training ◽  
Circuit Resistance

Objective: The overweight-related health problems among adolescents are obvious. Resistance training is recognized as a safe and efficacious exercise modality to have health-promoting effects in overweight adolescents. This study aimed to assess the efficacy of circuit resistance training (CRT) in improving inflammatory status, insulin resistance and body composition in overweight male adolescents. Materials and Methods: Twenty overweight adolescent boys (aged: 18.5 (±1), weight: 81.1 (±4.5), body mass index: 27.7 (±0.7)) completed this study. The participants were randomly and equally divided into two groups of control (CG; n=10) and circuit resistance training (CRT; n=10). The CG did their daily routine activities and the CRT group performed its training protocol 3 days a week for 6 weeks. Body composition components and serum variables were measured a day before and after the study. Insulin resistance index was measured by HOMA-IR. Results: The subjects in the CG showed significantly increased changes compared with pre-training values. Moreover, significant changes were found fort the changes of BW ( P -value= 0.005), BMI ( P -value= 0.001) and BF% ( P -value= 0.003) between groups. Conclusion: This study suggested that although six weeks of CRT failed to induce meaningful anti-inflammatory cytokine responses, and to improve body composition and HOMA-IR in overweight adolescent boys, but had protective effects on inflammatory status, HOMA-IR and body composition and prevented them from being deteriorated

The Effect of Circuit Resistance Training on Plasma Levels of Amino acids, Alpha-hydroxybutyrate, Mannose, and Urinary Levels of Glycine Conjugated Adducts in Obese Adolescent Boys

2020 ◽  
Author(s):  
Seyed Ali Rasooli ◽  
Rozita Fathi ◽  
Farhad Ahmadi-Kani Golzar ◽  
Masoumeh Baghersalimi
Keyword(s):  
Insulin Resistance ◽  
Amino Acids ◽  
Resistance Training ◽  
Plasma Levels ◽  
Control Group ◽  
Adolescent Boys ◽  
Obese Adolescent ◽  
Urinary Levels ◽  
Circuit Resistance Training ◽  
Circuit Resistance

Few studies have examined the improving effects of exercise on the association between metabolites of impaired protein metabolism and insulin resistance in obese children. Therefore, this study aims to investigate the effect of circuit resistance training (CRT) on plasma levels of amino acids, alpha-hydroxybutyrate (α-HB), mannose, and urinary levels of glycine conjugated adducts in obese adolescent boys. Forty obese adolescent boys (BMI above the 95th percentile) with an age range of 14-17 were randomly divided into CRT group (n= 20) and control group (n= 20). The CRT program (3 times/week, 70-80% of 1 repetition maximum) was performed for 8 weeks. The results indicated that the body composition and plasma levels of glucose, insulin resistance, valine, mannose, lysine and the sum of branched-chain amino acids (BCAAs) were decreased due to CRT. The plasma levels of asparagine, glycine, serine, and urinary levels of glycine conjugated adduct also increased in the CRT group. Although α-HB level decreased during CRT, it had no significant difference from that of the control group. It can be concluded that the improvement in obesity complications including insulin resistance in obese adolescent boys after CRT may be due to decrease in plasma levels of mannose and BCAAs and increase urinary metabolites. Novelty Bullets: • CRT improves glucose metabolism and insulin resistance in obese adolescent boys. • CRT decreases plasma levels of mannose and BCAAs and normalizes other amino acids. • CRT increases urinary levels of glycine conjugated adducts.

Osteocalcin is inversely associated with adiposity and leptin in adolescent boys

2015 ◽  
Vol 28 (5-6) ◽  
Author(s):  
Jaak Jürimäe ◽  
Evelin Lätt ◽  
Jarek Mäestu ◽  
Meeli Saar ◽  
Priit Purge ◽  
...  
Keyword(s):  
Physical Activity ◽  
Insulin Resistance ◽  
Body Mass ◽  
Body Fat ◽  
Bone Mineral ◽  
Fat Distribution ◽  
Body Fat Distribution ◽  
Adolescent Boys ◽  
Pubertal Stage ◽  
Daily Energy

AbstractRecently, osteocalcin (OC), an osteoblast-derived hormone, has been found to correlate with adiposity, adipocytokines and insulin resistance in adults, but few studies have investigated this in children. The aim of this study was to investigate these associations in adolescent boys, for whom it is a time of significant bone mineral accrual, taking into account possible confounders related to adipose and bone tissues.Participants were 141 adolescent boys (mean age 13.9±0.7 years), who were divided into tertiles according to OC levels. Across these groups, differences in total body fat mass (FM), body fat distribution, adiponectin, leptin and insulin resistance values were examined with relation to age, pubertal stage, daily energy and calcium intakes, and physical activity.Mean body mass index (BMI), FM, body fat% and leptin differed significantly between subjects in the three OC tertiles after adjustment for age, pubertal stage, energy and calcium intakes, and physical activity. There were no differences in fat free mass (FFM), bone mineral content, energy and calcium intakes, physical activity, adiponectin and insulin resistance values between study groups. For the entire cohort, mean serum OC was 130.2±45.2 ng/mL and was related to body mass, BMI, FM, body fat distribution and leptin. Circulating OC was not associated with FFM, daily energy and calcium intakes, physical activity, adiponectin or insulin resistance (insulin, glucose, homeostasis model assessment-insulin resistance) values.In male adolescents, OC is inversely related to body adiposity and leptin values, even after consideration of several factors that may affect bone and adipose tissues.

scholarly journals The effects of two weeks high-intensity interval training on fasting glucose, glucose tolerance and insulin resistance in adolescent boys; A pilot study

2019 ◽  
Author(s):  
Emma Cockcroft ◽  
Bert Bond ◽  
Craig A Williams ◽  
Sam Harris ◽  
Sarah R Jackman ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Health Outcomes ◽  
Negative Correlation ◽  
High Intensity ◽  
Interval Training ◽  
Current Evidence ◽  
High Intensity Interval Training ◽  
Adolescent Boys ◽  
Glucose Response ◽  
High Intensity Interval

Abstract Background : Current evidence of metabolic health benefits of high-intensity interval training (HIIT) are limited to longer training periods or conducted in overweight youth. This study assessed 1) fasting and postprandial insulin and glucose before and after two weeks of HIIT in healthy adolescent boys, and 2) the relationship between pre intervention health outcomes and the effects of the HIIT intervention. Methods: Seven healthy boys (age:14.3 ± 0.3 y, BMI: 21.6 ± 2.6, 3 participants classified as overweight) completed 6 sessions of HIIT over two weeks. Insulin resistance (IR) and blood glucose and insulin responses to a Mixed Meal Tolerance Test (MMTT) were assessed before (PRE), 20 h and 70 h after (POST) the final HIIT session. Results: Two weeks of HIIT had no effect on fasting plasma glucose, insulin or IR at 20 h and 70 h POST HIIT, nor insulin and glucose response to MMTT (all P>0.05). There was a strong negative correlation between PRE training IR and change in IR after HIIT (r =-0.96, P <0.05). Conclusion: Two weeks of HIIT did not elicit improvements to fasting or postprandial glucose or insulin health outcomes in a group of adolescent boys. However the negative correlation between PRE IR and improvements after HIIT suggest that interventions of this type may be effective in adolescents with raised baseline IR.

scholarly journals Elevated serum levels of free triiodothyronine in adolescent boys with gynaecomastia compared with controls

2014 ◽  
Vol 171 (2) ◽  
pp. 193-198 ◽  
Author(s):  
Mikkel G Mieritz ◽  
Kaspar Sorensen ◽  
Lise Aksglaede ◽  
Annette Mouritsen ◽  
Casper P Hagen ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Elevated Serum ◽  
Serum Levels ◽  
Adolescent Boys ◽  
Free Triiodothyronine ◽  
Pubertal Stage ◽  
Cross Sectional ◽  
Healthy Adolescent ◽  
Serum Free ◽  
Thyroid Hormone Levels

ObjectivePubertal gynaecomastia is a frequent phenomenon occurring in 20–40% of otherwise healthy adolescent boys. Little is known about the aetiology of pubertal gynaecomastia. Markedly elevated thyroid hormone levels in adults with hyperthyroidism are associated with gynaecomastia.DesignA cross-sectional examination of 444 healthy boys with and without pubertal gynaecomastia.MethodsWe evaluated TSH, triiodothyronine (T3), thyroxine (T4), free T4 and free T3 in a cohort of healthy boys with and without pubertal gynaecomastia.ResultsBoys with gynaecomastia had significantly higher serum free T3, even after correction for age, BMI and pubertal stage. After inclusion of IGF1 in the model the differences disappeared. TSH, T4, free T4 and T3 did not differ between the groups.ConclusionsWe speculate that the GH/IGF1 axis and thyroid hormones interact and influence the development of pubertal gynaecomastia.

scholarly journals Measuring testicular asymmetry in healthy adolescent boys

2018 ◽  
Vol 122 (4) ◽  
pp. 530-531
Author(s):  
Michael P. Kurtz ◽  
David A. Diamond
Keyword(s):  
Adolescent Boys ◽  
Healthy Adolescent

scholarly journals The effects of two weeks high-intensity interval training on fasting glucose, glucose tolerance and insulin resistance in adolescent boys: a pilot study

2019 ◽  
Vol 11 (1) ◽  
Author(s):  
Emma J. Cockcroft ◽  
Bert Bond ◽  
Craig A. Williams ◽  
Sam Harris ◽  
Sarah R. Jackman ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Health Outcomes ◽  
Negative Correlation ◽  
High Intensity ◽  
Interval Training ◽  
Current Evidence ◽  
High Intensity Interval Training ◽  
Adolescent Boys ◽  
Glucose Response ◽  
High Intensity Interval

Abstract Background Current evidence of metabolic health benefits of high-intensity interval training (HIIT) are limited to longer training periods or conducted in overweight youth. This study assessed 1) fasting and postprandial insulin and glucose before and after 2 weeks of HIIT in healthy adolescent boys, and 2) the relationship between pre intervention health outcomes and the effects of the HIIT intervention. Methods Seven healthy boys (age:14.3 ± 0.3 y, BMI: 21.6 ± 2.6, 3 participants classified as overweight) completed 6 sessions of HIIT over 2 weeks. Insulin resistance (IR) and blood glucose and insulin responses to a Mixed Meal Tolerance Test (MMTT) were assessed before (PRE), 20 h and 70 h after (POST) the final HIIT session. Results Two weeks of HIIT had no effect on fasting plasma glucose, insulin or IR at 20 h and 70 h POST HIIT, nor insulin and glucose response to MMTT (all P > 0.05). There was a strong negative correlation between PRE training IR and change in IR after HIIT (r = − 0.96, P < 0.05). Conclusion Two weeks of HIIT did not elicit improvements to fasting or postprandial glucose or insulin health outcomes in a group of adolescent boys. However the negative correlation between PRE IR and improvements after HIIT suggest that interventions of this type may be effective in adolescents with raised baseline IR.

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