scholarly journals Induced Pluripotent Stem Cells: Therapeutic Applications in Monogenic and Metabolic Diseases, and Regulatory and Bioethical Considerations

10.5772/55816 ◽  
2013 ◽  
Author(s):  
Antonio Liras ◽  
Cristina Segovia ◽  
Aline S.
Keyword(s):  
Stem Cells ◽  
Induced Pluripotent Stem Cells ◽  
Pluripotent Stem Cells ◽  
Metabolic Diseases ◽  
Therapeutic Applications ◽  
Induced Pluripotent

scholarly journals Induced pluripotent stem cells, a giant leap for mankind therapeutic applications

2019 ◽  
Vol 11 (7) ◽  
pp. 421-430 ◽  
Author(s):  
José Bragança ◽  
João André Lopes ◽  
Leonardo Mendes-Silva ◽  
João Miguel Almeida Santos
Keyword(s):  
Stem Cells ◽  
Induced Pluripotent Stem Cells ◽  
Pluripotent Stem Cells ◽  
Therapeutic Applications ◽  
Giant Leap ◽  
Induced Pluripotent

scholarly journals Human Hepatocyte-Derived Induced Pluripotent Stem Cells: MYC Expression, Similarities to Human Germ Cell Tumors, and Safety Issues

2016 ◽  
Vol 2016 ◽  
pp. 1-16 ◽  
Author(s):  
Carmen Unzu ◽  
Marc Friedli ◽  
Alexis Bosman ◽  
Marisa E. Jaconi ◽  
Barbara E. Wildhaber ◽  
...  
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Induced Pluripotent Stem Cells ◽  
Pluripotent Stem Cells ◽  
Metabolic Diseases ◽  
Germ Cell Tumors ◽  
Tumor Development ◽  
Hematopoietic Stem ◽  
Safety Issues ◽  
Induced Pluripotent

Induced pluripotent stem cells (iPSC) are a most promising approach to the development of a hepatocyte transplantable mass sufficient to induce long-term correction of inherited liver metabolic diseases, thus avoiding liver transplantation. Their intrinsic self-renewal ability and potential to differentiate into any of the three germ layers identify iPSC as the most promising cell-based therapeutics, but also as drivers of tumor development. Teratoma development currently represents the gold standard to assess iPSC pluripotency. We analyzed the tumorigenic potential of iPSC generated from human hepatocytes (HEP-iPSC) and compared their immunohistochemical profiles to that of tumors developed from fibroblast and hematopoietic stem cell-derived iPSC. HEP-iPSC generated tumors significantly presented more malignant morphological features than reprogrammed fibroblasts or CD34+ iPSC. Moreover, the protooncogenemycshowed the strongest expression in HEP-iPSC, compared to only faint expression in the other cell subsets. Random integration of transgenes and the use of potent protooncogenes such asmycmight be a risk factor for malignant tumor development if hepatocytes are used for reprogramming. Nonviral vector delivery systems or reprogramming of cells obtained from less invasive harvesting methods would represent interesting options for future developments in stem cell-based approaches for liver metabolic diseases.

Recent Advances in Therapeutic Applications of Induced Pluripotent Stem Cells

2017 ◽  
Vol 19 (2) ◽  
pp. 65-74 ◽  
Author(s):  
Farzaneh Rami ◽  
Shamsi Naderi Beni ◽  
Mahboobeh Mojaver Kahnamooi ◽  
Ilnaz Rahimmanesh ◽  
Ahmad Reza Salehi ◽  
...  
Keyword(s):  
Stem Cells ◽  
Induced Pluripotent Stem Cells ◽  
Pluripotent Stem Cells ◽  
Therapeutic Applications ◽  
Recent Advances ◽  
Induced Pluripotent

scholarly journals Detailed Characterization of Human Induced Pluripotent Stem Cells Manufactured for Therapeutic Applications

2016 ◽  
Vol 12 (4) ◽  
pp. 394-420 ◽  
Author(s):  
Behnam Ahmadian Baghbaderani ◽  
Adhikarla Syama ◽  
Renuka Sivapatham ◽  
Ying Pei ◽  
Odity Mukherjee ◽  
...  
Keyword(s):  
Stem Cells ◽  
Induced Pluripotent Stem Cells ◽  
Pluripotent Stem Cells ◽  
Detailed Characterization ◽  
Therapeutic Applications ◽  
Induced Pluripotent

Directed differentiation of mouse-induced pluripotent stem cells generates dopaminergic nerve

2010 ◽  
Vol 34 (8) ◽  
pp. S36-S36
Author(s):  
Ping Duan ◽  
Xuelin Ren ◽  
Wenhai Yan ◽  
Xuefei Han ◽  
Xu Yan ◽  
...  
Keyword(s):  
Stem Cells ◽  
Induced Pluripotent Stem Cells ◽  
Pluripotent Stem Cells ◽  
Directed Differentiation ◽  
Induced Pluripotent
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