scholarly journals Plant Based Natural Products and Breast Cancer: Considering Multi-Faceted Disease Aspects, Past Successes, and Promising Future Interventions

10.5772/55794 ◽  
2013 ◽  
Author(s):  
Gailene Tobin ◽  
Ruwani Kalupahana ◽  
Marianna Kulk
Keyword(s):  
Breast Cancer ◽  
Natural Products

Natural products that selectively target organotropic metastatic breast cancer

Planta Medica ◽  
2014 ◽  
Vol 80 (10) ◽  
Author(s):  
DG Nagle ◽  
F Mahdi ◽  
KP Li ◽  
YH Wang ◽  
M Wang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Natural Products ◽  
Metastatic Breast Cancer ◽  
Metastatic Breast

scholarly journals Dietary Natural Products for Prevention and Treatment of Breast Cancer

Nutrients ◽  
2017 ◽  
Vol 9 (7) ◽  
pp. 728 ◽  
Author(s):  
Ya Li ◽  
Sha Li ◽  
Xiao Meng ◽  
Ren-You Gan ◽  
Jiao-Jiao Zhang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Natural Products ◽  
Prevention And Treatment

scholarly journals Manumycin Polyketides Act as Molecular Glues Between UBR7 and P53 to Impair Breast Cancer Pathogenicity

2019 ◽  
Author(s):  
Yosuke Isobe ◽  
Mikiko Okumura ◽  
Ross White ◽  
Lynn M. McGregor ◽  
Jeffrey M. McKenna ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Natural Products ◽  
Product Family ◽  
Protein Profiling ◽  
Covalent Attachment ◽  
Therapeutic Modality ◽  
General Strategy ◽  
Anti Cancer ◽  
Protein Functions

AbstractMolecular glues are an intriguing therapeutic modality that harness small-molecules to induce interactions between proteins that typically do not interact, thus enabling the creation of novel protein functions not naturally encoded in biology. While molecular glues such as thalidomide and rapamycin have catalyzed drug discovery efforts, such molecules are rare and have often been discovered fortuitously, thus limiting their potential as a general strategy for therapeutic intervention of disease. Historically, natural products have proven to be important sources of molecular glues and we postulated that natural products bearing multiple electrophilic sites may be an unexplored source of such molecules, potentially through multi-covalent attachment. Using activity-based protein profiling (ABPP)-based chemoproteomic platforms, we show that members of the manumycin family of polyketides, which bear multiple potentially reactive sites, target C374 of the putative E3 ligase UBR7 in breast cancer cells to impair breast cancer pathogenicity through engaging in molecular glue interactions with the neo-substrate tumor-suppressor TP53, leading to the activation of p53 transcriptional activity and cell death. Our results reveal a previously undiscovered anti-cancer mechanism of this natural product family and highlight the potential for combining chemoproteomics and multi-covalent natural products for the discovery and characterization of new molecular glues.

Sign in / Sign up

Export Citation Format

Share Document