scholarly journals Disease Models for the Genetic Cardiac Diseases

10.5772/55773 ◽  
2013 ◽  
Author(s):  
Mari Pekkanen-Mattila ◽  
Kristiina Rajala ◽  
Katriina Aalto-Setl
Keyword(s):  
Disease Models ◽  
Cardiac Diseases

scholarly journals Comprehensive autophagy evaluation in cardiac disease models

2019 ◽  
Vol 116 (3) ◽  
pp. 483-504 ◽  
Author(s):  
Nina Kaludercic ◽  
Maria Chiara Maiuri ◽  
Susmita Kaushik ◽  
Álvaro F Fernández ◽  
Jenny de Bruijn ◽  
...  
Keyword(s):  
Cardiac Disease ◽  
Disease Models ◽  
Cardiac Diseases ◽  
Critical Pathway ◽  
Cellular Homeostasis ◽  
Pathophysiological Role ◽  
Cardiac System

Abstract Autophagy is a highly conserved recycling mechanism essential for maintaining cellular homeostasis. The pathophysiological role of autophagy has been explored since its discovery 50 years ago, but interest in autophagy has grown exponentially over the last years. Many researchers around the globe have found that autophagy is a critical pathway involved in the pathogenesis of cardiac diseases. Several groups have created novel and powerful tools for gaining deeper insights into the role of autophagy in the aetiology and development of pathologies affecting the heart. Here, we discuss how established and emerging methods to study autophagy can be used to unravel the precise function of this central recycling mechanism in the cardiac system.

Breakthrough Regenerative Cardiopoietic Stem Cells and Related Technologies in the Field of Cardiovascular Medicine – From Bench to Bedside

2012 ◽  
Vol 7 (1) ◽  
pp. 14
Author(s):  
Christian Homsy ◽  
Keyword(s):  
Stem Cells ◽  
Cell Therapy ◽  
Progenitor Cells ◽  
Cardiac Disease ◽  
Cardiac Tissue ◽  
Cardiac Repair ◽  
Cardiac Diseases ◽  
Cardiac Progenitor Cells ◽  
Biotechnology Company ◽  
Cardiovascular Medicine

The scale of cardiac diseases, and in particular heart failure and acute myocardial infarction, emphasises the need for radically new approaches, such as cell therapy, to address the underlying cause of the disease, the loss of functional myocardium. Stem cell-based therapies, whether through transplanted cells or directing innate repair, may provide regenerative approaches to cardiac diseases by halting, or even reversing, the events responsible for progression of organ failure. Cardio3 BioSciences, a leading Belgian biotechnology company focused on the discovery and development of regenerative and protective therapies for the treatment of cardiac disease, was founded in this context in 2004. The company is developing a highly innovative cell therapy approach based on a platform designed to reprogramme the patient’s own stem cells into cardiac progenitor cells. The underlying rationale behind this approach is that, in order to reconstruct cardiac tissue, stem cells need to be specific to cardiac tissue. The key is therefore to provide cardiac-specific progenitor cells to the failing heart to induce cardiac repair.

New forms of physical exercise for patients with cardiac diseases

2017 ◽  
Vol 18 (6) ◽  
pp. 555-560
Author(s):  
T.T. Kakuchaya ◽  
T.G. Dzhitava ◽  
N.V. Pachuashvili
Keyword(s):  
Physical Exercise ◽  
Cardiac Diseases
Sign in / Sign up

Export Citation Format

Share Document