scholarly journals Sorafenib-Inhibited Signaling: Emerging Evidence of RAFIndependent Pathways as Potential Therapeutic Targets in Hepatocellular Carcinoma

10.5772/55201 ◽  
2013 ◽  
Author(s):  
Yasunobu Matsuda ◽  
Toshifumi Wakai ◽  
Masayuki Kubota ◽  
Mami Osawa ◽  
Shun Fujimaki
Keyword(s):  
Hepatocellular Carcinoma ◽  
Therapeutic Targets

scholarly journals The Expression and Function of Circadian Rhythm Genes in Hepatocellular Carcinoma

2021 ◽  
Vol 2021 ◽  
pp. 1-13
Author(s):  
Yanan Jiang ◽  
Xiuyun Shen ◽  
Moyondafoluwa Blessing Fasae ◽  
Fengnan Zhi ◽  
Lu Chai ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Circadian Rhythm ◽  
Circadian Rhythms ◽  
Molecular Mechanisms ◽  
Therapeutic Targets ◽  
Pathogenic Mechanism ◽  
Research Progress ◽  
Biological Processes ◽  
And Function ◽  
Novel Therapeutic

Hepatocellular carcinoma (HCC) is among the most common and lethal form of cancer worldwide. However, its diagnosis and treatment are still dissatisfactory, due to limitations in the understanding of its pathogenic mechanism. Therefore, it is important to elucidate the molecular mechanisms and identify novel therapeutic targets for HCC. Circadian rhythm-related genes control a variety of biological processes. These genes play pivotal roles in the initiation and progression of HCC and are potential diagnostic markers and therapeutic targets. This review gives an update on the research progress of circadian rhythms, their effects on the initiation, progression, and prognosis of HCC, in a bid to provide new insights for the research and treatment of HCC.

scholarly journals Non-coding RNA in hepatocellular carcinoma: Mechanisms, biomarkers and therapeutic targets

2017 ◽  
Vol 67 (3) ◽  
pp. 603-618 ◽  
Author(s):  
Marcel Klingenberg ◽  
Akiko Matsuda ◽  
Sven Diederichs ◽  
Tushar Patel
Keyword(s):  
Hepatocellular Carcinoma ◽  
Therapeutic Targets ◽  
Non Coding Rna

RAS/RAF/MEK/ERK, PI3K/PTEN/AKT/mTORC1 and TP53 pathways and regulatory miRs as therapeutic targets in hepatocellular carcinoma

2019 ◽  
Vol 23 (11) ◽  
pp. 915-929 ◽  
Author(s):  
Shaw M. Akula ◽  
Stephen L. Abrams ◽  
Linda S. Steelman ◽  
Maria R. Emma ◽  
Giuseppa Augello ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Therapeutic Targets

Abstract 2935: RNAi screen identifies therapeutic targets in hepatocellular carcinoma

2014 ◽  
Author(s):  
Chun-Hao Huang ◽  
Amaia Lujambio ◽  
Johannes Zuber ◽  
Thomas Kitzing ◽  
Darjus F. Tschaharganeh ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Therapeutic Targets ◽  
Rnai Screen

Genetically Distinct and Clinically Relevant Classification of Hepatocellular Carcinoma: Putative Therapeutic Targets

2007 ◽  
Vol 133 (5) ◽  
pp. 1475-1486 ◽  
Author(s):  
Hiroto Katoh ◽  
Hidenori Ojima ◽  
Akiko Kokubu ◽  
Shigeru Saito ◽  
Tadashi Kondo ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Therapeutic Targets
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