scholarly journals A Novel Therapy for Melanoma and Prostate Cancer Using a Non-Replicating Sendai Virus Particle (HVJ-E)

10.5772/55014 ◽  
2013 ◽  
Author(s):  
Toshihiro Nakajima ◽  
Toshimitsu Itai ◽  
Hiroshi Wada ◽  
Toshie Yamauchi ◽  
Eiji Kiyohara ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Virus Particle ◽  
Sendai Virus ◽  
Novel Therapy

scholarly journals Chromatin-directed proteomics-identified network of endogenous androgen receptor in prostate cancer cells

Oncogene ◽  
2021 ◽  
Author(s):  
Kaisa-Mari Launonen ◽  
Ville Paakinaho ◽  
Gianluca Sigismondo ◽  
Marjo Malinen ◽  
Reijo Sironen ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Target Genes ◽  
Epithelial Mesenchymal Transition ◽  
Protein A ◽  
Chorioallantoic Membrane ◽  
Chromatin Accessibility ◽  
Castration Resistant Prostate Cancer ◽  
Novel Therapy ◽  
Mesenchymal Transition

AbstractTreatment of prostate cancer confronts resistance to androgen receptor (AR)-targeted therapies. AR-associated coregulators and chromatin proteins hold a great potential for novel therapy targets. Here, we employed a powerful chromatin-directed proteomics approach termed ChIP-SICAP to uncover the composition of chromatin protein network, the chromatome, around endogenous AR in castration resistant prostate cancer (CRPC) cells. In addition to several expected AR coregulators, the chromatome contained many nuclear proteins not previously associated with the AR. In the context of androgen signaling in CRPC cells, we further investigated the role of a known AR-associated protein, a chromatin remodeler SMARCA4 and that of SIM2, a transcription factor without a previous association with AR. To understand their role in chromatin accessibility and AR target gene expression, we integrated data from ChIP-seq, RNA-seq, ATAC-seq and functional experiments. Despite the wide co-occurrence of SMARCA4 and AR on chromatin, depletion of SMARCA4 influenced chromatin accessibility and expression of a restricted set of AR target genes, especially those involved in cell morphogenetic changes in epithelial-mesenchymal transition. The depletion also inhibited the CRPC cell growth, validating SMARCA4’s functional role in CRPC cells. Although silencing of SIM2 reduced chromatin accessibility similarly, it affected the expression of a much larger group of androgen-regulated genes, including those involved in cellular responses to external stimuli and steroid hormone stimulus. The silencing also reduced proliferation of CRPC cells and tumor size in chick embryo chorioallantoic membrane assay, further emphasizing the importance of SIM2 in CRPC cells and pointing to the functional relevance of this potential prostate cancer biomarker in CRPC cells. Overall, the chromatome of AR identified in this work is an important resource for the field focusing on this important drug target.

scholarly journals Reciprocal feedback inhibition of the androgen receptor and PI3K as a novel therapy for castrate-sensitive and -resistant prostate cancer

Oncotarget ◽  
2015 ◽  
Vol 6 (39) ◽  
pp. 41976-41987 ◽  
Author(s):  
Wenqing Qi ◽  
Carla Morales ◽  
Laurence S. Cooke ◽  
Benny Johnson ◽  
Bradley Somer ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Feedback Inhibition ◽  
Novel Therapy

scholarly journals Systemically Delivered Magnetic Hyperthermia for Prostate Cancer Treatment

Pharmaceutics ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 1020
Author(s):  
Hassan A. Albarqi ◽  
Ananiya A. Demessie ◽  
Fahad Y. Sabei ◽  
Abraham S. Moses ◽  
Mikkel N. Hansen ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Animal Studies ◽  
Water Solubility ◽  
Polymeric Nanoparticles ◽  
Magnetic Hyperthermia ◽  
Hydrophobic Core ◽  
Prostate Cancer Treatment ◽  
Novel Therapy ◽  
Heating Efficiency ◽  
Poly Ethylene

Herein, we report a novel therapy for prostate cancer based on systemically delivered magnetic hyperthermia. Conventional magnetic hyperthermia is a form of thermal therapy where magnetic nanoparticles delivered to cancer sites via intratumoral administration produce heat in the presence of an alternating magnetic field (AMF). To employ this therapy for prostate cancer tumors that are challenging to inject intratumorally, we designed novel nanoclusters with enhanced heating efficiency that reach prostate cancer tumors after systemic administration and generate desirable intratumoral temperatures upon exposure to an AMF. Our nanoclusters are based on hydrophobic iron oxide nanoparticles doped with zinc and manganese. To overcome the challenges associated with the poor water solubility of the synthesized nanoparticles, the solvent evaporation approach was employed to encapsulate and cluster them within the hydrophobic core of PEG-PCL (methoxy poly(ethylene glycol)-b-poly(ε-caprolactone))-based polymeric nanoparticles. Animal studies demonstrated that, following intravenous injection into mice bearing prostate cancer grafts, the nanoclusters efficiently accumulated in cancer tumors within several hours and increased the intratumoral temperature above 42 °C upon exposure to an AMF. Finally, the systemically delivered magnetic hyperthermia significantly inhibited prostate cancer growth and did not exhibit any signs of toxicity.

Dual targeting of EZH2 and androgen receptor as a novel therapy for castration-resistant prostate cancer

2020 ◽  
Vol 404 ◽  
pp. 115200 ◽  
Author(s):  
Eswar Shankar ◽  
Daniel Franco ◽  
Omair Iqbal ◽  
Stephen Moreton ◽  
Rajnee Kanwal ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Castration Resistant Prostate Cancer ◽  
Novel Therapy ◽  
Castration Resistant ◽  
Dual Targeting

A biomimetic approach to hormone resistant prostate cancer cell isolation using inactivated Sendai virus (HVJ-E)

2016 ◽  
Vol 4 (1) ◽  
pp. 96-103 ◽  
Author(s):  
Takaharu Okada ◽  
Koichiro Uto ◽  
Takao Aoyagi ◽  
Mitsuhiro Ebara
Keyword(s):  
Prostate Cancer ◽  
Cancer Cell ◽  
Metastatic Prostate Cancer ◽  
Prostate Cancer Cell ◽  
Sendai Virus ◽  
Cell Isolation ◽  
Biomimetic Approach ◽  
Hormone Resistant Prostate Cancer ◽  
Immobilization Method ◽  
Cancer Cell Isolation

A versatile immobilization method of inactivated Sendai virus (HVJ-E) for metastatic prostate cancer cell isolation.

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