scholarly journals Mechanism of Urinary Bladder Carcinogenesis Induced by a Xanthine Oxidoreductase Inhibitor, in Rats

10.5772/54971 ◽  
2013 ◽  
Author(s):  
Naoki Naoki ◽  
Takeo Shimo
Keyword(s):  
Urinary Bladder ◽  
Xanthine Oxidoreductase ◽  
Bladder Carcinogenesis ◽  
Xanthine Oxidoreductase Inhibitor

scholarly journals Xanthine oxidoreductase inhibitor topiroxostat ameliorates podocyte injury by inhibiting the reduction of nephrin and podoplanin

Nefrología ◽  
2021 ◽  
Author(s):  
Ying Zhang ◽  
Yoshiyasu Fukusumi ◽  
Mutsumi Kayaba ◽  
Takashi Nakamura ◽  
Ryusuke Sakamoto ◽  
...  
Keyword(s):  
Xanthine Oxidoreductase ◽  
Podocyte Injury ◽  
Xanthine Oxidoreductase Inhibitor

scholarly journals Influence of xanthine oxidoreductase inhibitor, topiroxostat, on body weight of diabetic obese mice

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Takashi Nakamura ◽  
Mai Nampei ◽  
Takayo Murase ◽  
Etsuko Satoh ◽  
Seigo Akari ◽  
...  
Keyword(s):  
Body Weight ◽  
Food Intake ◽  
Ketone Body ◽  
The Body ◽  
Xanthine Oxidoreductase ◽  
Diabetic Mellitus ◽  
Triglyceride Content ◽  
Xanthine Oxidoreductase Inhibitor ◽  
Single Regression ◽  
Muscle Triglyceride

AbstractPlasma xanthine oxidoreductase (XOR) activity is high in metabolic disorders such as diabetic mellitus, obesity, or overweight. Thus, this study investigated whether the XOR inhibitor, topiroxostat, affected body weight. Male db/db mice were fed standard diets with or without topiroxostat for 4 weeks. Body weight and food intake were constantly monitored, along with monitoring plasma biochemical markers, including insulin and XOR activity. Additionally, hepatic hypoxanthine and XOR activity were also documented. Single regression analysis was performed to determine the mechanism. Topiroxostat treatment suppressed weight gain relative to the vehicle without any impact on food intake. However, the weight of fat pads and hepatic and muscle triglyceride content did not change. Topiroxostat decreased the plasma uric acid and increased hepatic hypoxanthine in response to the inhibition of XOR activity. Plasma ketone body and free fatty acid were also increased. Moreover, fat weight was weakly associated with plasma XOR activity in the diabetic state and was negatively associated with ketone body by topiroxostat. These results suggested that topiroxostat amplified the burning of lipids and the salvage pathway, resulting in predisposing the body toward catabolism. The inhibition of plasma XOR activity may contribute to weight loss.

Lack of promotion of N-butyl-N-(4-hydroxybutyl)nitrosamine-initiated urinary bladder carcinogenesis in mice by rat cancer promoters

1993 ◽  
Vol 13 (2) ◽  
pp. 89-96 ◽  
Author(s):  
Seiko Tamano ◽  
Emiko Asakawa ◽  
Pleumjit Boomyaphiphat ◽  
Tsuneo Masui ◽  
Shoji Fukushima
Keyword(s):  
Urinary Bladder ◽  
Bladder Carcinogenesis

Suppression of AhR signaling pathway is associated with the down-regulation of UDP-glucuronosyltransferases during BBN-induced urinary bladder carcinogenesis in mice

2009 ◽  
Vol 147 (3) ◽  
pp. 353-360 ◽  
Author(s):  
Katsuyuki Iida ◽  
Junsei Mimura ◽  
Ken Itoh ◽  
Chikara Ohyama ◽  
Yoshiaki Fujii-Kuriyama ◽  
...  
Keyword(s):  
Urinary Bladder ◽  
Signaling Pathway ◽  
Down Regulation ◽  
Bladder Carcinogenesis

EFFECTS OF SIROLIMUS ON RAT URINARY BLADDER CARCINOGENESIS

2008 ◽  
Vol 7 (3) ◽  
pp. 211
Author(s):  
B. Parada ◽  
A. Figueiredo ◽  
F. Reis ◽  
P. Nunes ◽  
P. Eufrásio ◽  
...  
Keyword(s):  
Urinary Bladder ◽  
Rat Urinary Bladder ◽  
Bladder Carcinogenesis

Suppressive Effect of Matrine on Tumor Invasion in N-Butyl-N-(4-Hydroxybutyl)Nitrosamine-Induced Urinary Bladder Carcinogenesis

Chemotherapy ◽  
2014 ◽  
Vol 60 (2) ◽  
pp. 119-128 ◽  
Author(s):  
Hua Gao ◽  
Yafang Guo ◽  
Ning Deng ◽  
Pingxia Fei ◽  
Xiaofeng Qiu ◽  
...  
Keyword(s):  
Urinary Bladder ◽  
Tumor Invasion ◽  
Suppressive Effect ◽  
Bladder Carcinogenesis
Sign in / Sign up

Export Citation Format

Share Document