scholarly journals The Role of Cortical Modularity in Tactile Information Processing: An Approach to Measuring Information Processing Deficits in Autism

10.5772/54801 ◽  
2013 ◽  
Author(s):  
Eric Francisco ◽  
Oleg Favorov ◽  
Mark Tommerdahl
Keyword(s):  
Information Processing ◽  
Tactile Information ◽  
Processing Deficits ◽  
Information Processing Deficits

scholarly journals Impairments in sensory-motor gating and information processing in a mouse model of Ehmt1 haploinsufficiency

2020 ◽  
Vol 4 ◽  
pp. 239821282092864
Author(s):  
Brittany A Davis ◽  
François David ◽  
Ciara O’Regan ◽  
Manal A Adam ◽  
Adrian J Harwood ◽  
...  
Keyword(s):  
Information Processing ◽  
Mouse Model ◽  
Neurodevelopmental Disorders ◽  
Auditory Evoked Potentials ◽  
Autism Spectrum ◽  
Oscillatory Activity ◽  
Kleefstra Syndrome ◽  
Sensory Motor ◽  
Processing Deficits ◽  
Information Processing Deficits

Regulators of chromatin dynamics and transcription are increasingly implicated in the aetiology of neurodevelopmental disorders. Haploinsufficiency of EHMT1, encoding a histone methyltransferase, is associated with several neurodevelopmental disorders, including Kleefstra syndrome, developmental delay and autism spectrum disorder. Using a mouse model of Ehmt1 haploinsufficiency ( Ehmt1D6Cre/+), we examined a number of brain and behavioural endophenotypes of relevance to neurodevelopmental disorders. Specifically, we show that Ehmt1D6Cre/+ mice have deficits in information processing, evidenced by abnormal sensory-motor gating, a complete absence of object recognition memory, and a reduced magnitude of auditory evoked potentials in both paired-pulse inhibition and mismatch negativity. The electrophysiological experiments show that differences in magnitude response to auditory stimulus were associated with marked reductions in total and evoked beta- and gamma-band oscillatory activity, as well as significant reductions in phase synchronisation. The pattern of electrophysiological deficits in Ehmt1D6Cre/+ matches those seen in control mice following administration of the selective NMDA-R antagonist, ketamine. This, coupled with reduction of Grin1 mRNA expression in Ehmt1D6Cre/+ hippocampus, suggests that Ehmt1 haploinsufficiency may lead to disruption in NMDA-R. Taken together, these data indicate that reduced Ehmt1 dosage during forebrain development leads to abnormal circuitry formation, which in turn results in profound information processing deficits. Such information processing deficits are likely paramount to our understanding of the cognitive and neurological dysfunctions shared across the neurodevelopmental disorders associated with EHMT1 haploinsufficiency.

Core information processing deficits in developmental dyscalculia and low numeracy

2008 ◽  
Vol 11 (5) ◽  
pp. 669-680 ◽  
Author(s):  
Teresa Iuculano ◽  
Joey Tang ◽  
Charles W.B. Hall ◽  
Brian Butterworth
Keyword(s):  
Information Processing ◽  
Developmental Dyscalculia ◽  
Processing Deficits ◽  
Information Processing Deficits
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