scholarly journals Cerebrospinal Fluid Abnormalities in Viral Encephalitis

Encephalitis ◽  
10.5772/54590 ◽  
2013 ◽  
Author(s):  
Hakan Ekmekci ◽  
Fahrettin Ege ◽  
Serefnur Ozturk
Keyword(s):  
Cerebrospinal Fluid ◽  
Viral Encephalitis

Chapter 10: Diagnosis

2019 ◽  
Author(s):  
Gerhard Dobler
Keyword(s):  
Cerebrospinal Fluid ◽  
Viral Encephalitis ◽  
Clinical Symptoms ◽  
Serological Tests ◽  
Specific Antibodies ◽  
Cross Reactions ◽  
Neuro Imaging ◽  
Tbev Infection

• TBE appears with non-characteristic clinical symptoms, which cannot be distinguished from oth-er forms of viral encephalitis or other diseases. • Cerebrospinal fluid and neuro-imaging may give some evidence of TBE, but ultimately cannot confirm the diagnosis. • Thus, proving the diagnosis “TBE” necessarily requires confirmation of TBEV-infection by detec-tion of the virus or by demonstration of specific antibodies from serum and/or cerebrospinal fluid. • During the phase of clinic symptoms from the CNS, the TBEV can only rarely be detected in the cerebrospinal fluid of patients. • Most routinely used serological tests for diagnosing TBE (ELISA, HI, IFA) show cross reactions resulting from either Infection with other flaviviruses or with other flavivirus vaccines.

Chapter 10: Diagnosis

2020 ◽  
Keyword(s):  
Cerebrospinal Fluid ◽  
Viral Encephalitis ◽  
Clinical Symptoms ◽  
Serological Tests ◽  
Specific Antibodies ◽  
Cross Reactions ◽  
Neuro Imaging ◽  
Tbev Infection

TBE appears with non-characteristic clinical symptoms, which cannot be distinguished from other forms of viral encephalitis or other diseases. Cerebrospinal fluid and neuro-imaging may give some evidence of TBE, but ultimately cannot confirm the diagnosis. Thus, proving the diagnosis “TBE” necessarily requires confirmation of TBEV-infection by detection of the virus or by demonstration of specific antibodies from serum and/or cerebrospinal fluid. During the phase of clinic symptoms from the CNS, the TBEV can only rarely be detected in the cerebrospinal fluid of patients. Most routinely used serological tests for diagnosing TBE (ELISA, HI, IFA) show cross reactions resulting from either infection with other flaviviruses or with other flavivirus vaccines.

A Case Report: The CSF Characteristics of HaNDL Syndrome

2020 ◽  
Vol 13 (2) ◽  
pp. 103-107
Author(s):  
Sarah E. McKay ◽  
Melanie R. F. Greenway
Keyword(s):  
Cerebrospinal Fluid ◽  
Migraine With Aura ◽  
Viral Encephalitis ◽  
Recurrent Stroke ◽  
Unique Case ◽  
Laboratory Findings ◽  
Cerebral Ischemic ◽  
Ischemic Events ◽  
Insight Into ◽  
Csf Findings

BackgroundHeadache and Neurologic Deficits with cerebrospinal fluid Lymphocytosis (HaNDL) is a rare and underdiagnosed syndrome that mimics recurrent stroke, migraine with aura, and encephalitis.ObjectiveDescribe the presentation, clinical characteristics, and cerebrospinal fluid (CSF) findings in a patient with HaNDL and provide insight into the importance of the recognition of this syndrome.MethodsThe authors describe a unique case of (HaNDL) during which the patient underwent three lumbar punctures over 26 days.ResultsThe authors demonstrate the natural course of CSF characteristics of a patient with HaNDL, with rising and falling lymphocyte counts. Additionally, the authors provide an example of the clinical presentation of HaNDL, with episodic attacks over the course of 1 month of migraine headache, hemibody paresthesias, hemibody weakness, and encephalopathy.ConclusionsHaNDL is a headache syndrome mimicking viral encephalitis, migraine with aura, and recurrent cerebral ischemic events. While HaNDL is a diagnosis of exclusion, the syndrome's association with characteristic clinical and laboratory findings are important to recognize. Furthermore, a monophasic pattern of CSF lymphocytosis in HaNDL may be observed.Implications for NursingIncreased recognition of this syndrome may help prevent unnecessary tests and treatments when patients present with recurrent episodes.

An Increase of Cerebrospinal Fluid B-cell Activating Factor Level in Pediatric Patients With Acute Viral Encephalitis

2017 ◽  
Vol 70 ◽  
pp. e3-e4
Author(s):  
Mitsuo Motobayashi ◽  
Tetsuhiro Fukuyama ◽  
Jiu Okuno-Yuguchi ◽  
Takahiro Shioiri ◽  
Sachiko Nagaharu ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
B Cell ◽  
Pediatric Patients ◽  
Viral Encephalitis ◽  
Factor Level ◽  
B Cell Activating Factor

Cerebrospinal Fluid and Serum C-Reactive Protein among Children with Acute Encephalitis Syndrome

2021 ◽  
Vol 16 (03) ◽  
pp. 111-115
Author(s):  
Durgesh Kumar ◽  
Dinesh Kumar ◽  
Alok Tiwari ◽  
Nishant Sharma ◽  
Rajesh Kumar Yadav ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Cerebral Malaria ◽  
Tuberculous Meningitis ◽  
Viral Encephalitis ◽  
C Reactive Protein ◽  
Pyogenic Meningitis ◽  
Reactive Protein ◽  
Acute Encephalitis Syndrome ◽  
Acute Encephalitis ◽  
Serum Crp

Abstract Objectives This study aimed to evaluate the positivity of C-reactive protein (CRP) in cerebrospinal fluid (CSF) and serum in children presented with clinical diagnosis of acute encephalitis syndrome (AES). Methods A total of 164 children between 6 months and 14 years with clinical diagnosis of AES were investigated. Qualitative CRP (slide agglutination) was determined in CSF and serum sample of each patient. On the basis of clinical examination and investigations, all the patients were divided into four groups as pyogenic meningitis, viral encephalitis, tuberculous meningitis, and cerebral malaria. The positivity of CRP in CSF and serum were compared in these groups. Results CSF CRP was found to be positive in the majority of patients with pyogenic meningitis and a statistically significant (p ≤ 0.001) association was found between CSF CRP and final diagnosis of AES, while this association was nonsignificant (p = 0.141) in case of serum CRP. When we compared the CSF and serum CRP, serum CRP was found to be more suggestive of tuberculous meningitis, viral encephalitis, and cerebral malaria while CSF CRP was more sensitive and specific for the diagnosis of pyogenic meningitis. Conclusion The sensitivity and specificity of CSF CRP for pyogenic meningitis was quite high. Serum CRP with a high sensitivity can be used as a screening test for different types of meningitis and cerebral malaria; however, its diagnostic accuracy has yet to be established.

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