scholarly journals Serum Leptin and Bone Turnover Markers in Postmenopausal Osteoporosis

10.5772/54527 ◽  
2013 ◽  
Author(s):  
Mehreen Lateef ◽  
Mukhtiar Baig ◽  
Abid Azhar
Keyword(s):  
Bone Turnover ◽  
Postmenopausal Osteoporosis ◽  
Bone Turnover Markers ◽  
Serum Leptin ◽  
Turnover Markers

scholarly journals Serumβ-Catenin Levels Associated with the Ratio of RANKL/OPG in Patients with Postmenopausal Osteoporosis

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Xiao-Juan Xu ◽  
Lin Shen ◽  
Yan-Ping Yang ◽  
Rui Zhu ◽  
Bo Shuai ◽  
...  
Keyword(s):  
Bone Turnover ◽  
Postmenopausal Women ◽  
Postmenopausal Osteoporosis ◽  
Bone Turnover Markers ◽  
Enzyme Linked Immunosorbent Assay ◽  
Functional Communication ◽  
Mineral Density ◽  
Wnt Pathways ◽  
Turnover Markers

Objective. To demonstrate the role of Wnt/β-catenin canonical pathway in postmenopausal osteoporosis by evaluating serumβ-catenin levels in patients with postmenopausal osteoporosis and analyzing their possible relationship with serum OPG, RANKL, the ratio of RANKL/OPG, sclerostin, and bone turnover markers.Methods. 480 patients with postmenopausal osteoporosis and 170 healthy postmenopausal women were enrolled in the study. Serumβ-catenin, OPG, RANKL, and sclerostin levels were measured by enzyme-linked immunosorbent assay. Bone status was assessed by measuring bone mineral density and bone turnover markers. Estradiol levels were also detected.Results. Serumβ-catenin levels were lower in postmenopausal osteoporotic women compared to nonosteoporotic postmenopausal women (26.26±14.81versus39.33±5.47 pg/mL,P<0.001). Serumβ-catenin was positively correlated with osteoprotegerin (r=0.232,P<0.001) and negatively correlated with the ratio of RANKL/OPG, body mass index, and sclerostin (r=-0.128,P=0.005;r=-0.117,P=0.010;r=-0.400,P<0.001, resp.) in patients with postmenopausal osteoporosis.Conclusion. The results indicate that lower serumβ-catenin and concomitantly higher ratio of RANKL/OPG may be involved in the pathogenesis of postmenopausal osteoporosis. Functional communication between RANKL/RANK/OPG system and Wnt pathways plays an important role in postmenopausal osteoporosis.

Prognostic interest of bone turnover markers in the management of postmenopausal osteoporosis

2012 ◽  
Vol 79 (1) ◽  
pp. 26-31 ◽  
Author(s):  
Florence Chopin ◽  
Emmanuel Biver ◽  
Thomas Funck-Brentano ◽  
Béatrice Bouvard ◽  
Guillaume Coiffier ◽  
...  
Keyword(s):  
Bone Turnover ◽  
Postmenopausal Osteoporosis ◽  
Bone Turnover Markers ◽  
Turnover Markers

High Adiposity and Serum Leptin Accompanied by Altered Bone Turnover Markers in Severe Juvenile Idiopathic Arthritis

2014 ◽  
Vol 41 (12) ◽  
pp. 2474-2481 ◽  
Author(s):  
Kati P. Markula-Patjas ◽  
Kaisa K. Ivaska ◽  
Minna Pekkinen ◽  
Sture Andersson ◽  
Eeva Moilanen ◽  
...  
Keyword(s):  
Juvenile Idiopathic Arthritis ◽  
Bone Turnover ◽  
Disease Activity ◽  
Fat Mass ◽  
Bone Turnover Markers ◽  
Type I ◽  
Inverse Association ◽  
Body Composition Assessment ◽  
Serum Leptin ◽  
Turnover Markers

Objective.To evaluate interactions between skeleton and adipose tissue, and association of adipokines and bone turnover markers with disease-related factors in patients with severe juvenile idiopathic arthritis (JIA).Methods.Forty-nine patients (median age 14.8 yrs, median disease duration 10.2 yrs) with refractory polyarticular JIA and 89 sex-matched and age-matched healthy controls participated in the study. Study subjects underwent clinical examination, body composition assessment with dual-energy X-ray absorptiometry, and analyses for leptin, adiponectin, and bone turnover markers.Results.Patients with JIA were shorter and more often overweight (p = 0.001) or obese (p < 0.001) than controls. They had significantly higher serum leptin, even when adjusted for fat mass (p < 0.001), than did controls. Adiponectin did not differ between the groups. Concentration of carboxyterminal telopeptide of type I collagen was higher (p = 0.006) in patients. The inverse association between leptin and bone turnover markers disappeared in controls but was strengthened in patients when adjusted for fat mass. Leptin, adiponectin, or bone markers did not associate with variables of disease activity.Conclusion.Patients with severe JIA had high adiposity accompanied by increased bone resorption. Their serum leptin was higher, even independently of fat mass. Leptin tended to associate inversely with bone turnover markers but did not associate with variables of disease activity.

scholarly journals Response of bone turnover markers to three oral bisphosphonate therapies in postmenopausal osteoporosis: the TRIO study

2015 ◽  
Vol 27 (1) ◽  
pp. 21-31 ◽  
Author(s):  
K. E. Naylor ◽  
R. M. Jacques ◽  
M. Paggiosi ◽  
F. Gossiel ◽  
N. F. A. Peel ◽  
...  
Keyword(s):  
Bone Turnover ◽  
Postmenopausal Osteoporosis ◽  
Bone Turnover Markers ◽  
Oral Bisphosphonate ◽  
Turnover Markers

scholarly journals Effect of Monitoring Bone Turnover Markers on Persistence with Risedronate Treatment of Postmenopausal Osteoporosis

2007 ◽  
Vol 92 (4) ◽  
pp. 1296-1304 ◽  
Author(s):  
Pierre D. Delmas ◽  
Bernard Vrijens ◽  
Richard Eastell ◽  
Christian Roux ◽  
Huibert A. P. Pols ◽  
...  
Keyword(s):  
Bone Turnover ◽  
Postmenopausal Osteoporosis ◽  
Bone Turnover Markers ◽  
Turnover Markers
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