scholarly journals Lipid Inclusions in Mycobacterial Infections

10.5772/54526 ◽  
2013 ◽  
Author(s):  
Matthias Stehr ◽  
Ayssar A. ◽  
Mahavir Singh
Keyword(s):  
Mycobacterial Infections ◽  
Lipid Inclusions

Mycobacterial Infections: The Link to Ink

2012 ◽  
Vol 43 (10) ◽  
pp. 8
Author(s):  
MICHELE G. SULLIVAN
Keyword(s):  
Mycobacterial Infections

Role of the macrophage-inducible C-type lectin Mincle in the lung host defense against mycobacterial infections in mice

Pneumologie ◽  
2011 ◽  
Vol 65 (12) ◽  
Author(s):  
F Behler ◽  
K Steinwede ◽  
R Maus ◽  
J Bohling ◽  
UA Maus
Keyword(s):  
Host Defense ◽  
Mycobacterial Infections

scholarly journals Lopinavir and Nelfinavir Induce the Accumulation of Crystalloid Lipid Inclusions within the Reservosomes of Trypanosoma cruzi and Inhibit Both Aspartyl-Type Peptidase and Cruzipain Activities Detected in These Crucial Organelles

2021 ◽  
Vol 6 (3) ◽  
pp. 120
Author(s):  
Leandro S. Sangenito ◽  
Miria G. Pereira ◽  
Thais Souto-Padron ◽  
Marta H. Branquinha ◽  
André L. S. Santos
Keyword(s):  
Trypanosoma Cruzi ◽  
Opportunistic Infections ◽  
Lipid Inclusion ◽  
Transmission Electron ◽  
New Information ◽  
Lipid Inclusions ◽  
Immunodeficiency Virus ◽  
Parasite Viability ◽  
Aspartyl Peptidases ◽  
New Evidence

Several research groups have explored the repositioning of human immunodeficiency virus aspartyl peptidase inhibitors (HIV-PIs) on opportunistic infections caused by bacteria, fungi and protozoa. In Trypanosoma cruzi, HIV-PIs have a high impact on parasite viability, and one of the main alterations promoted by this treatment is the imbalance in the parasite’s lipid metabolism. However, the reasons behind this phenomenon are unknown. In the present work, we observed by transmission electron microscopy (TEM) that the treatment of T. cruzi epimastigotes with the HIV-PIs lopinavir and nelfinavir induced a huge accumulation of crystalloid-shaped lipids within the reservosomes, most of them deforming these key organelles. As previously reported, those structures are characteristic of lipid inclusions formed mostly of cholesterol and cholesterol-esters. The fractionation of nontreated epimastigotes generated two distinct fractions enriched in reservosomes: one mostly composed of lipid inclusion-containing reservosomes (Fraction B1) and one where lipid inclusions were much less abundant (Fraction B2). Interestingly, the extract of Fraction B2 presented enzymatic activity related to aspartyl-type peptidases 3.5 times higher than that found in the extract obtained from Fraction B1. The cleavage of cathepsin D substrate by this class of peptidases was strongly impaired by pepstatin A, a prototypical aspartyl PI, and the HIV-PIs lopinavir and nelfinavir. In addition, both HIV-PIs also inhibited (to a lesser extent) the cruzipain activity present in reservosomes. Finally, our work provides new evidence concerning the presence and supposed participation of aspartyl peptidases in T. cruzi, even as it adds new information about the mechanisms behind the alterations promoted by lopinavir and nelfinavir in the protozoan.

scholarly journals Estrogen-Related Lipid Inclusions in Mouse Uterine Stroma

1979 ◽  
Vol 20 (4) ◽  
pp. 823-829 ◽  
Author(s):  
Roberta G. Pourcho ◽  
Stanley F. Gould ◽  
Maurice H. Bernstein
Keyword(s):  
Lipid Inclusions

The prevalence of non-tuberculous mycobacterial infections in mainland China: Systematic review and meta-analysis

2016 ◽  
Vol 73 (6) ◽  
pp. 558-567 ◽  
Author(s):  
Xia Yu ◽  
Pengnian Liu ◽  
Guan Liu ◽  
Liping Zhao ◽  
Yanjie Hu ◽  
...  
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Mainland China ◽  
Mycobacterial Infections
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