scholarly journals To Grow, Stop or Die? – Novel Tumor-Suppressive Mechanism Regulated by the Transcription Factor E2F

10.5772/54510 ◽  
2013 ◽  
Author(s):  
Eiko Ozono ◽  
Shoji Yamaoka ◽  
Kiyoshi Ohtani
Keyword(s):  
Transcription Factor ◽  
Transcription Factor E2f ◽  
Suppressive Mechanism

The Transcription Factor E2F-1 in SV40 T Antigen-Induced Cerebellar Purkinje Cell Degeneration

1998 ◽  
Vol 12 (1-2) ◽  
pp. 16-28 ◽  
Author(s):  
Maria C. Athanasiou ◽  
Wael Yunis ◽  
Natalie Coleman ◽  
Robert Ehlenfeldt ◽  
H.Brent Clark ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Purkinje Cell ◽  
T Antigen ◽  
Cerebellar Purkinje Cell ◽  
Sv40 T Antigen ◽  
Cell Degeneration ◽  
Purkinje Cell Degeneration ◽  
Transcription Factor E2f

scholarly journals Molecular cloning of cellular genes encoding retinoblastoma-associated proteins: identification of a gene with properties of the transcription factor E2F.

1992 ◽  
Vol 12 (12) ◽  
pp. 5620-5631 ◽  
Author(s):  
B Shan ◽  
X Zhu ◽  
P L Chen ◽  
T Durfee ◽  
Y Yang ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Mammalian Cells ◽  
Leucine Zipper ◽  
T Antigen ◽  
Transactivation Domain ◽  
Recognition Sequence ◽  
Cellular Genes ◽  
Genes Encoding ◽  
Associated Proteins ◽  
Transcription Factor E2f

The retinoblastoma protein interacts with a number of cellular proteins to form complexes which are probably crucial for its normal physiological function. To identify these proteins, we isolated nine distinct clones by direct screening of cDNA expression libraries using purified RB protein as a probe. One of these clones, Ap12, is expressed predominantly at the G1-S boundary and in the S phase of the cell cycle. The nucleotide sequence of Ap12 has features characteristic of transcription factors. The C-terminal region binds to unphosphorylated RB in regions similar to those to which T antigen binds and contains a transactivation domain. A region containing a potential leucine zipper flanked by basic residues is able to bind an E2F recognition sequence specifically. Expression of Ap12 in mammalian cells significantly enhances E2F-dependent transcriptional activity. These results suggest that Ap12 encodes a protein with properties known to be characteristic of transcription factor E2F.

scholarly journals Functions of Cyclin A1 in the Cell Cycle and Its Interactions with Transcription Factor E2F-1 and the Rb Family of Proteins

1999 ◽  
Vol 19 (3) ◽  
pp. 2400-2407 ◽  
Author(s):  
Rong Yang ◽  
Carsten Müller ◽  
Vong Huynh ◽  
Yuen K. Fung ◽  
Amy S. Yee ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Transcription Factor ◽  
Mitotic Cell ◽  
Histone H1 ◽  
Mitotic Cell Cycle ◽  
Osteosarcoma Cell ◽  
Cell Cycle Regulators ◽  
Cyclin A1 ◽  
Transcription Factor E2f

ABSTRACT Human cyclin A1, a newly discovered cyclin, is expressed in testis and is thought to function in the meiotic cell cycle. Here, we show that the expression of human cyclin A1 and cyclin A1-associated kinase activities was regulated during the mitotic cell cycle. In the osteosarcoma cell line MG63, cyclin A1 mRNA and protein were present at very low levels in cells at the G0 phase. They increased during the progression of the cell cycle and reached the highest levels in the S and G2/M phases. Furthermore, the cyclin A1-associated histone H1 kinase activity peaked at the G2/M phase. We report that cyclin A1 could bind to important cell cycle regulators: the Rb family of proteins, the transcription factor E2F-1, and the p21 family of proteins. The in vitro interaction of cyclin A1 with E2F-1 was greatly enhanced when cyclin A1 was complexed with CDK2. Associations of cyclin A1 with Rb and E2F-1 were observed in vivo in several cell lines. When cyclin A1 was coexpressed with CDK2 in sf9 insect cells, the CDK2-cyclin A1 complex had kinase activities for histone H1, E2F-1, and the Rb family of proteins. Our results suggest that the Rb family of proteins and E2F-1 may be important targets for phosphorylation by the cyclin A1-associated kinase. Cyclin A1 may function in the mitotic cell cycle in certain cells.

scholarly journals Regulation of FGF receptor-2 expression by transcription factor E2F-1

Oncogene ◽  
2003 ◽  
Vol 22 (36) ◽  
pp. 5630-5635 ◽  
Author(s):  
Etsu Tashiro ◽  
Yusuke Minato ◽  
Hiroko Maruki ◽  
Masataka Asagiri ◽  
Masaya Imoto
Keyword(s):  
Transcription Factor ◽  
Fgf Receptor ◽  
Transcription Factor E2f

Association of cdk2 kinase with the transcription factor E2F during S phase

Science ◽  
1992 ◽  
Vol 255 (5048) ◽  
pp. 1144-1147 ◽  
Author(s):  
M Pagano ◽  
G Draetta ◽  
P Jansen-Durr
Keyword(s):  
Transcription Factor ◽  
S Phase ◽  
Transcription Factor E2f

scholarly journals Cell growth-regulated expression of mammalian MCM5 and MCM6 genes mediated by the transcription factor E2F

Oncogene ◽  
1999 ◽  
Vol 18 (14) ◽  
pp. 2299-2309 ◽  
Author(s):  
Kiyoshi Ohtani ◽  
Ritsuko Iwanaga ◽  
Masataka Nakamura ◽  
Masa-aki Ikeda ◽  
Norikazu Yabuta ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Cell Growth ◽  
Regulated Expression ◽  
Transcription Factor E2f
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