scholarly journals Modification of Sex Hormones with RGD-Peptide: A Strategy of Improving HRT and Other Secondary Osteoporosis Therapy

10.5772/54361 ◽  
2013 ◽  
Author(s):  
Ming Zhao ◽  
Yuji Wang ◽  
Jianhui Wu ◽  
Shiqi Peng
Keyword(s):  
Sex Hormones ◽  
Rgd Peptide ◽  
Secondary Osteoporosis ◽  
Osteoporosis Therapy

Secondary Osteoporosis

2021 ◽  
Author(s):  
Peter R Ebeling ◽  
Hanh H Nguyen ◽  
Jasna Aleksova ◽  
Amanda J Vincent ◽  
Phillip Wong ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Bone Mass ◽  
Fracture Risk ◽  
Trabecular Bone Score ◽  
Public Health Problem ◽  
Premenopausal Women ◽  
Secondary Osteoporosis ◽  
Osteoporosis Therapy ◽  
Underlying Condition

Abstract Osteoporosis is a global public health problem, with fractures contributing to significant morbidity and mortality. Although postmenopausal osteoporosis is most common, up to 30% of postmenopausal women, > 50% of premenopausal women, and between 50% and 80% of men have secondary osteoporosis. Exclusion of secondary causes is important, as treatment of such patients often commences by treating the underlying condition. These are varied but often neglected, ranging from endocrine to chronic inflammatory and genetic conditions. General screening is recommended for all patients with osteoporosis, with advanced investigations reserved for premenopausal women and men aged < 50 years, for older patients in whom classical risk factors for osteoporosis are absent, and for all patients with the lowest bone mass (Z-score ≤ −2). The response of secondary osteoporosis to conventional anti-osteoporosis therapy may be inadequate if the underlying condition is unrecognized and untreated. Bone densitometry, using dual-energy x-ray absorptiometry, may underestimate fracture risk in some chronic diseases, including glucocorticoid-induced osteoporosis, type 2 diabetes, and obesity, and may overestimate fracture risk in others (eg, Turner syndrome). FRAX and trabecular bone score may provide additional information regarding fracture risk in secondary osteoporosis, but their use is limited to adults aged ≥ 40 years and ≥ 50 years, respectively. In addition, FRAX requires adjustment in some chronic conditions, such as glucocorticoid use, type 2 diabetes, and HIV. In most conditions, evidence for antiresorptive or anabolic therapy is limited to increases in bone mass. Current osteoporosis management guidelines also neglect secondary osteoporosis and these existing evidence gaps are discussed.

Sex Hormones Mediate Effect Of PTH in Men

2006 ◽  
Vol 36 (2) ◽  
pp. 30
Author(s):  
Kerri Wachter
Keyword(s):  
Sex Hormones ◽  
Mediate Effect

Oral Osteoporosis Therapy Choices Are Expanding

2007 ◽  
Vol 37 (11) ◽  
pp. 18
Author(s):  
SHERRY BOSCHERT
Keyword(s):  
Osteoporosis Therapy

THE EFFECT OF GONADECTOMY ON THE RESPONSE OF THE PITUITARY I. C. S. H.-CONTENT TO STEROID SEX HORMONES

1960 ◽  
Vol XXXV (II) ◽  
pp. 245-252 ◽  
Author(s):  
G. P. van Rees ◽  
F. J. A. Paesi
Keyword(s):  
Sex Hormones ◽  
Sex Steroids ◽  
Low Dose ◽  
Testosterone Propionate ◽  
Preceding Paper ◽  
Direct Consequence ◽  
Two Factors ◽  
Reflex Stimulation ◽  
Steroid Sex Hormones ◽  
Stimulation Of

ABSTRACT In the experiments reported in this paper the hypothesis that the decrease in the pituitary I. C. S. H.-content, which occurs after administration of steroid sex hormones in gonadectomized animals, is counteracted by a reflex stimulation of the hypophysis initiated by the operation has been investigated. If treatment with a low dose of testosterone propionate (100 μg) was started immediately after castration, the resulting decrease in the pituitary I. C. S. H.-content became more marked if the reflex stimulation of the hypophysis had been prevented. If, however, two months were allowed to elapse before the beginning of treatment, the presence or absence of this reflex was no longer of importance for the effect of testosterone propionate on the pituitary I. C. S. H.-content. And yet, in this case too, the decrease in the pituitary I. C. S. H.-content by testosterone propionate was less than in intact animals (see preceding paper). Hence this decrease appears to be counteracted by two factors: one rapidly occurring and short lasting, resulting from a reflex elicited by gonadectomy; the other gradually increasing in potency and possibly a direct consequence of the continued absence of pituitary inhibiting sex steroids.

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