scholarly journals Molecular Bases of Ataxia Telangiectasia: One Kinase Multiple Functions

10.5772/54045 ◽  
2013 ◽  
Author(s):  
Venturina Stagni ◽  
Simonetta Santini ◽  
Daniela Baril
Keyword(s):  
Ataxia Telangiectasia ◽  
Multiple Functions ◽  
Molecular Bases

scholarly journals From Yeast to Mammals, the Nonsense-Mediated mRNA Decay as a Master Regulator of Long Non-Coding RNAs Functional Trajectory

2021 ◽  
Vol 7 (3) ◽  
pp. 44
Author(s):  
Sara Andjus ◽  
Antonin Morillon ◽  
Maxime Wery
Keyword(s):  
Quality Control ◽  
Mrna Decay ◽  
Environmental Changes ◽  
Master Regulator ◽  
Rna Surveillance ◽  
Multiple Functions ◽  
Functional Roles ◽  
Nonsense Mediated Mrna Decay ◽  
Non Coding Rnas ◽  
Molecular Bases

The Nonsense-Mediated mRNA Decay (NMD) has been classically viewed as a translation-dependent RNA surveillance pathway degrading aberrant mRNAs containing premature stop codons. However, it is now clear that mRNA quality control represents only one face of the multiple functions of NMD. Indeed, NMD also regulates the physiological expression of normal mRNAs, and more surprisingly, of long non-coding (lnc)RNAs. Here, we review the different mechanisms of NMD activation in yeast and mammals, and we discuss the molecular bases of the NMD sensitivity of lncRNAs, considering the functional roles of NMD and of translation in the metabolism of these transcripts. In this regard, we describe several examples of functional micropeptides produced from lncRNAs. We propose that translation and NMD provide potent means to regulate the expression of lncRNAs, which might be critical for the cell to respond to environmental changes.

Ataxia-telangiectasia

1966 ◽  
Vol 94 (2) ◽  
pp. 226a-227
Author(s):  
W. G. Larsen
Keyword(s):  
Ataxia Telangiectasia

Ataxia telangiectasia in dizygotic two year old twins

2011 ◽  
Vol 42 (S 01) ◽  
Author(s):  
M Henrich ◽  
S Lutz ◽  
M Busse ◽  
U Schara
Keyword(s):  
Ataxia Telangiectasia

Forgiveness and the Multiple Functions of Anger

2019 ◽  
Vol 1 (1) ◽  
pp. 44-71
Author(s):  
Antony G. Aumann ◽  
◽  
Zac Cogley ◽  
◽  
Keyword(s):  
Multiple Functions

Molecular Bases of Protective Immune Responses against BotuIInum Neurotoxin A—How Antitoxin Antibodies Block Its Action

2007 ◽  
Vol 27 (4) ◽  
pp. 319-341 ◽  
Author(s):  
M. Zouhair Atassi ◽  
Behzod Z. Dolimbek ◽  
Lance E. Steward ◽  
K. Roger Aoki
Keyword(s):  
Immune Responses ◽  
Molecular Bases

2118-P: Regulation of Ataxia-Telangiectasia and Rad3-Related (ATR)–Dependent DNA Damage Response by Nitric Oxide in ß-Cells

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 2118-P
Author(s):  
CHAY TENG YEO ◽  
BRYNDON OLESON ◽  
JOHN A. CORBETT ◽  
JAMIE K. SCHNUCK
Keyword(s):  
Nitric Oxide ◽  
Dna Damage ◽  
Dna Damage Response ◽  
Ataxia Telangiectasia ◽  
Damage Response

Features of DNA repair in dermal fibroblasts in ataxia-telangiectasia patients with mosaic type of manifestation of active ATM kinase

2020 ◽  
Vol XV (1) ◽  
Author(s):  
M. Kuranova ◽  
A. Nozdracheva ◽  
R. Ushakov ◽  
T. Ledashcheva ◽  
L. Schugareva ◽  
...  
Keyword(s):  
Dna Repair ◽  
Ataxia Telangiectasia ◽  
Dermal Fibroblasts ◽  
Atm Kinase
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