scholarly journals Importance of Dietary Fatty Acid Profile and Experimental Conditions in the Obese Insulin-Resistant Rodent Model of Metabolic Syndrome

10.5772/53805 ◽  
2012 ◽  
Author(s):  
Annadie Krygsman
2004 ◽  
Vol 32 (6) ◽  
pp. 999-1002 ◽  
Author(s):  
H.M. Roche

Nutrition is a key environmental factor that is particularly involved in the pathogenesis and progression of several polygenic, diet-related diseases. Nutrigenomics refers to the interaction between nutrition and the human genome. Dietary fatty acids interact with multiple nutrient-sensitive transcription factors. This explains the molecular basis of some of the health effects associated with altered dietary fatty acid composition. The metabolic syndrome is a very common condition, characterized by insulin resistance, abdominal obesity, dyslipidaemia and hypertension. It often precedes Type 2 diabetes mellitus, and is associated with a greater risk of cardiovascular disease. Several lines of evidence suggest that the interaction between nutrient-derived metabolic stressors and pro-inflammatory signals play an important role in the aetiology of insulin resistance and the development of the metabolic syndrome. This paper will address the interaction between several nutrient-sensitive transcription factors, including SREBP (sterol-regulatory-element-binding protein) and NFκB (nuclear factor κB), demonstrating how this interaction may be altered with dietary fatty acid interventions.


Nutrition ◽  
2011 ◽  
Vol 27 (10) ◽  
pp. 1002-1007 ◽  
Author(s):  
Azita Hekmatdoost ◽  
Parvin Mirmiran ◽  
Firoozeh Hosseini-Esfahani ◽  
Fereidoun Azizi

2013 ◽  
Vol 21 (4) ◽  
Author(s):  
Cristina Casado ◽  
Javier Moya ◽  
Juan José Pascual ◽  
Enrique Blas ◽  
Concha Cervera

2005 ◽  
Vol 37 (3) ◽  
pp. 95-102 ◽  
Author(s):  
Yuko Kawakami ◽  
Yasuko Murakami ◽  
Takayo Kawakami ◽  
Naomi Muroyama ◽  
Takao Takiue ◽  
...  

2020 ◽  
Vol 11 (1) ◽  
pp. 13
Author(s):  
Vasudevan Sudha ◽  
Nagarajan Lakshmipriya ◽  
Rajagopal Gayathri ◽  
Shobana Shanmugam ◽  
Ramprasad Srinivasan ◽  
...  

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