scholarly journals Signaling Pathways and Biomarkers in Renal Tumors

Renal Tumor ◽  
10.5772/53787 ◽  
2013 ◽  
Author(s):  
Tetsuo Fujita ◽  
Masatsugu Iwamura ◽  
Kazumasa Matsumoto ◽  
Kazunari Yoshi
Keyword(s):  
Signaling Pathways ◽  
Renal Tumors

A compendium of G-protein–coupled receptors and cyclic nucleotide regulation of adipose tissue metabolism and energy expenditure

2020 ◽  
Vol 134 (5) ◽  
pp. 473-512 ◽  
Author(s):  
Ryan P. Ceddia ◽  
Sheila Collins
Keyword(s):  
Adipose Tissue ◽  
Energy Expenditure ◽  
Signaling Pathways ◽  
G Protein ◽  
Uncoupling Protein ◽  
Beige Adipocytes ◽  
Nucleotide Regulation ◽  
Ucp1 Expression ◽  
Thermogenic Adipocytes ◽  
G Protein Coupled

Abstract With the ever-increasing burden of obesity and Type 2 diabetes, it is generally acknowledged that there remains a need for developing new therapeutics. One potential mechanism to combat obesity is to raise energy expenditure via increasing the amount of uncoupled respiration from the mitochondria-rich brown and beige adipocytes. With the recent appreciation of thermogenic adipocytes in humans, much effort is being made to elucidate the signaling pathways that regulate the browning of adipose tissue. In this review, we focus on the ligand–receptor signaling pathways that influence the cyclic nucleotides, cAMP and cGMP, in adipocytes. We chose to focus on G-protein–coupled receptor (GPCR), guanylyl cyclase and phosphodiesterase regulation of adipocytes because they are the targets of a large proportion of all currently available therapeutics. Furthermore, there is a large overlap in their signaling pathways, as signaling events that raise cAMP or cGMP generally increase adipocyte lipolysis and cause changes that are commonly referred to as browning: increasing mitochondrial biogenesis, uncoupling protein 1 (UCP1) expression and respiration.

919: Ureteral Extension in Childhood Renal Tumors: A Report From the National Wilms Tumor Study Group (NWTSG)

2007 ◽  
Vol 177 (4S) ◽  
pp. 305-305
Author(s):  
Shane Daley ◽  
Michael Ritchey ◽  
Robert Shamberger ◽  
Robert Sawin ◽  
Thomas Hamilton ◽  
...  
Keyword(s):  
Wilms Tumor ◽  
Renal Tumors ◽  
Study Group ◽  
Tumor Study ◽  
Tumor Study Group

493: Radical Nephrectomy is Associated with Increased Mortality in Patients with Small Renal Tumors

2007 ◽  
Vol 177 (4S) ◽  
pp. 164-165 ◽  
Author(s):  
William C. Huang ◽  
Elena B. Elkin ◽  
Thomas L. Jang ◽  
Paul Russo
Keyword(s):  
Radical Nephrectomy ◽  
Renal Tumors

657: Normal Appearing Renal Parenchyma Surrounding Renal Tumors Demonstrates Abnormal Cytogenetics

2005 ◽  
Vol 173 (4S) ◽  
pp. 179-179
Author(s):  
Tony Mammen ◽  
Samuel P. Sterrett ◽  
K.C. Balaji
Keyword(s):  
Renal Parenchyma ◽  
Renal Tumors

651: The Clinical Importance of Very Small Renal Tumors

2005 ◽  
Vol 173 (4S) ◽  
pp. 177-178
Author(s):  
Heiko Wunderlich ◽  
Alexander Berndt ◽  
Winfried Hindermann ◽  
Kerstin Junker ◽  
Jörg Schubert ◽  
...  
Keyword(s):  
Clinical Importance ◽  
Renal Tumors

47: Nephron Wasting Surgery for Small Renal Tumors

2005 ◽  
Vol 173 (4S) ◽  
pp. 13-14
Author(s):  
Rahuldev S. Bhalla ◽  
Kalyan C. Lotchamsetty ◽  
Paul M. Kozlowski ◽  
Thomas R. Hefty ◽  
Christopher R. Porter
Keyword(s):  
Renal Tumors

46: Intermediate Follow-Up Comparison between Partial Nephrectomy and Radio Frequency Ablation in T1A Renal Tumors

2006 ◽  
Vol 175 (4S) ◽  
pp. 16-16 ◽  
Author(s):  
Joshua M. Stern ◽  
Robert S. Svatek ◽  
Sangtae Park ◽  
J. Kyle Anderson ◽  
Yair Lotan ◽  
...  
Keyword(s):  
Radio Frequency ◽  
Partial Nephrectomy ◽  
Radio Frequency Ablation ◽  
Renal Tumors

79: Probe Ablation for Renal Tumors: Comparison of Cryoablation and Radiofrequency Ablation

2006 ◽  
Vol 175 (4S) ◽  
pp. 26-26
Author(s):  
Nicholas J. Hegarty ◽  
Jihad H. Kaouk ◽  
Eric Remer ◽  
Charles M. O'Malley ◽  
Mihir M. Desai ◽  
...  
Keyword(s):  
Radiofrequency Ablation ◽  
Renal Tumors

1650: Novel Gene Expression Markers in Renal Tumors Using Rt-PCR on Fixed Tissues Useful in Differentiating Histologic Subtypes

2004 ◽  
Vol 171 (4S) ◽  
pp. 436-436
Author(s):  
John A. Petros ◽  
Audry N. Schuetz ◽  
Andrew N. Young ◽  
Q. Yin Goen ◽  
So Dug Lim ◽  
...  
Keyword(s):  
Gene Expression ◽  
Renal Tumors ◽  
Rt Pcr ◽  
Novel Gene ◽  
Histologic Subtypes
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