scholarly journals Pharmacological Treatment of Acute Ischemic Stroke

10.5772/53774 ◽  
2013 ◽  
Author(s):  
Humberto Mestre ◽  
Yael Cohen-Minian ◽  
Daniel Zajarias-Fainsod ◽  
Antonio Ibarr
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Pharmacological Treatment

scholarly journals PHARMACOLOGICAL TREATMENT OF ACUTE ISCHEMIC STROKE: A REVIEW

2017 ◽  
Vol 8 (5) ◽  
pp. 23-29
Author(s):  
Bipin Kumar Nayak ◽  
Arun Kumar ◽  
Shailendra Kumar Sah
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Pharmacological Treatment

Abstract WP269: Shift Towards Earlier Time to Presentation of Ischemic Strokes at a Regional Tele-Stroke Network After Endovascular Stroke Trials

Stroke ◽  
2017 ◽  
Vol 48 (suppl_1) ◽  
Author(s):  
Aashish Anand ◽  
Suman Nalluri ◽  
Tanzila Shams ◽  
Naregnia Pierre-Louis ◽  
Chandril Chugh ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Pharmacological Treatment ◽  
Group Analysis ◽  
Limiting Factor ◽  
Referral Pattern ◽  
Urban Centers ◽  
Prospective Data ◽  
Stroke Treatment ◽  
Stroke Registry

Introduction: The presentation of results of endovascular stroke treatment trials at the International Stroke Conference (ISC) in February 2015 was a landmark event in the treatment of acute ischemic strokes. Time to treatment remains the main limiting factor in the success of both endovascular and pharmacological treatment of acute ischemic strokes. This study aims to evaluate if publication of these trials has positively impacted the time to presentation for acute ischemic strokes at a regional tele-stroke network. Methods: Clinical data of all stroke consults from 17 months (October 2013 to February 2015) before, and 17 months (March 2015 to July 2016) after presentation of endovascular trials at ISC 2015 was collected from a prospective regional tele-stroke registry. Trends in time to presentation of acute ischemic strokes in the pre-trials and post-trials period were compared. Results: Prospective data of 7176 consecutive tele-stroke consults is presented. There was a significant increase in proportion of tele-stroke calls for acute ischemic stroke referrals in the post-trials period compared to pre-trials period [2792 (84%) versus 2297 (69%), p=0.002]. On sub-group analysis, this trend was seen in the referrals from urban “in-network” hospitals [p=0.02]. There was no change in the referral pattern from rural “out-of-network” hospitals [p=0.2]. In the post-trials period, there was an increase in the proportion of stroke presentations within 4 1/2 hours “window period” and 4.5 to 12 hours, and a decrease in presentation beyond 12 hours [ 4 ½ hrs: 16% vs. 14%; 4 ½-12 hrs: 36% vs. 33%; >12 hrs: 48% vs. 53%, p=0.009] Conclusions: The advent of landmark stroke trials appears to have increased awareness towards stroke treatment, resulting in higher referrals and earlier time to presentation from urban centers, but not rural centers.

Predictive value of the ankle brachial index in patients with acute ischemic stroke

VASA ◽  
2014 ◽  
Vol 43 (1) ◽  
pp. 55-61 ◽  
Author(s):  
Konstantinos Tziomalos ◽  
Vasilios Giampatzis ◽  
Stella Bouziana ◽  
Athinodoros Pavlidis ◽  
Marianna Spanou ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Hospital Mortality ◽  
Acute Ischemic Stroke ◽  
Ankle Brachial Index ◽  
Arterial Disease ◽  
National Institutes Of Health ◽  
Limited Data ◽  
Severe Stroke ◽  
Hospital Outcome ◽  
Peripheral Arterial

Background: Peripheral arterial disease (PAD) is frequently present in patients with acute ischemic stroke. However, there are limited data regarding the association between ankle brachial index (ABI) ≤ 0.90 (which is diagnostic of PAD) or > 1.40 (suggesting calcified arteries) and the severity of stroke and in-hospital outcome in this population. We aimed to evaluate these associations in patients with acute ischemic stroke. Patients and methods: We prospectively studied 342 consecutive patients admitted for acute ischemic stroke (37.4 % males, mean age 78.8 ± 6.4 years). The severity of stroke was assessed with the National Institutes of Health Stroke Scale (NIHSS)and the modified Rankin scale (mRS) at admission. The outcome was assessed with the mRS and dependency (mRS 2 - 5) at discharge and in-hospital mortality. Results: An ABI ≤ 0.90 was present in 24.6 % of the patients whereas 68.1 % had ABI 0.91 - 1.40 and 7.3 % had ABI > 1.40. At admission, the NIHSS score did not differ between the 3 groups (10.4 ± 10.6, 8.3 ± 9.3 and 9.3 ± 9.4, respectively). The mRS score was also comparable in the 3 groups (3.6 ± 1.7, 3.1 ± 1.8 and 3.5 ± 2.3, respectively). At discharge, the mRS score did not differ between the 3 groups (2.9 ± 2.2, 2.3 ± 2.1 and 2.7 ± 2.5, respectively) and dependency rates were also comparable (59.5, 47.6 and 53.3 %, respectively). In-hospital mortality was almost two-times higher in patients with ABI ≤ 0.90 than in patients with ABI 0.91 - 1.40 or > 1.40 but this difference was not significant (10.9, 6.6 and 6.3 %, respectively). Conclusions: An ABI ≤ 0.90 or > 1.40 does not appear to be associated with more severe stroke or worse in-hospital outcome in patients with acute ischemic stroke.

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