scholarly journals Surgical and Oncological Results of Treatment of Metastases of Renal Cell Carcinoma to the Contralateral Adrenal Gland

Renal Tumor ◽  
10.5772/53745 ◽  
2013 ◽  
Author(s):  
Archil Chkhotua ◽  
Laurent Managadze ◽  
Ambrosi Perti
2017 ◽  
Vol 8 (3) ◽  
pp. 326-330 ◽  
Author(s):  
R. B. Nerli ◽  
S. M. Patil ◽  
Amey Pathade ◽  
R. A. Patil ◽  
N. D. Pingale ◽  
...  

2020 ◽  
Vol 22 (3) ◽  
pp. 149-153
Author(s):  
N. A. Ognerubov ◽  
T. S. Antipova ◽  
G. E. Gumareva

Renal cell cancer metastases without evidence of a primary tumor are extremely rare. These variants are usually showed as a spontaneous description of single clinical cases. Aim.This contribution is a clinical follow-up of synchronous renal cell cancer metastases of unknown primary site. Results.A 52-year-old patient U. with a history of increased blood pressure, up to 170/100 mmHg for the last 5 years, who had undergone many instrumental examinations, including ultrasound examination, because of this disease. The computed tomography of the abdomen showed a 4975 mm heterogeneous tumor in the right adrenal gland in October 2017. The combined positron emission and X-ray computed tomography showed a 795441 mm mass in the right adrenal gland, associated with elevated fluorodeoxyglucose metabolic activity SUVmax 7.25. Focal accumulation of the radiopharmaceutical SUVmax 4.31 in a 171124 mm mass was detected in the space of bifurcation in the mediastinum. The lytic lesion (1015 mm) was found in right superior L3 articular process. The patient underwent retroperitoneoscopic adrenalectomy and thoracoscopic removal of mediastinal tumor in November 2017 because of the oligometastatic nature of the process. The histological study identified clear-cell carcinoma with areas of papillary structure in the right adrenal gland. The immunohistochemical study showed carcinoma cells intensively expressing CD10, and some other cells RCC. The immune phenotype of the tumor was identified as clear-cell renal cell carcinoma. The immunohistological and immunohistochemical analysis reviled the metastases of the same variant of renal cell carcinoma in one of 9 lymph nodes. The patient was treated with pazopanib. The primary renal tumor was not detected during the dynamic observation, including the application of annual combined positron emission and X-ray computed tomography. The patient is alive without disease progression with a follow-up of 32 months. Conclusion.Metastases of clear-cell renal cell carcinoma, including adrenal gland, without evidence of a primary site are extremely rare. The main method of treatment is a combination of surgery and targeted therapy, providing long-term local control of the course of the disease.


Urology ◽  
1998 ◽  
Vol 51 (4) ◽  
pp. 539-543 ◽  
Author(s):  
O.J Kessler ◽  
E Mukamel ◽  
R Weinstein ◽  
E Gayer ◽  
M Konichezky ◽  
...  

1992 ◽  
Vol 59 (6) ◽  
pp. 47-50
Author(s):  
G. De Marchi ◽  
G.N. Drei ◽  
F. Faccioli ◽  
M. Meneguolo ◽  
S. Guazzieri

Between 1980 and 1990, 135 patients underwent nephrectomy in our Department for renal cell carcinoma. Two groups were identified: Group 1 (72 patients) had the adrenal gland removed; group 2 (63 patients) did not undergo removal of the gland. In group 1 only one patient had ipsilateral adrenal gland neoplastic involvement. This patient also had hepatic metastasis and died 4 months after surgery. Differences in the time of survival after surgery were not statistically significant between groups. In the light of present findings and on the basis of data reported in literature, the problem of systematic adrenalectomy as part of radical nephrectomy is discussed.


2005 ◽  
Vol 173 (4S) ◽  
pp. 269-270 ◽  
Author(s):  
JohnS Lam ◽  
Jean-Jacques Patard ◽  
John T. Leppert ◽  
Francois Guille ◽  
Bernard Lobel ◽  
...  

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