scholarly journals Colon Cancer: Current Treatments and Preclinical Models for the Discovery and Development of New Therapies

10.5772/53391 ◽  
2013 ◽  
Author(s):  
Samuel Constant ◽  
Song Huang ◽  
Ludovic Wiszniewski ◽  
Christophe Mas
Keyword(s):  
Colon Cancer ◽  
Preclinical Models ◽  
New Therapies

scholarly journals Animal models of gastrointestinal and liver diseases. New mouse models for studying dietary prevention of colorectal cancer

2014 ◽  
Vol 307 (3) ◽  
pp. G249-G259 ◽  
Author(s):  
James C. Fleet
Keyword(s):  
Colorectal Cancer ◽  
Colon Cancer ◽  
Mouse Models ◽  
Human Colon ◽  
Low Grade ◽  
Preclinical Models ◽  
Dietary Interventions ◽  
Single Model ◽  
Human Colon Cancer ◽  
Molecular Etiology

Colorectal cancer is a heterogeneous disease that is one of the major causes of cancer death in the U.S. There is evidence that lifestyle factors like diet can modulate the course of this disease. Demonstrating the benefit and mechanism of action of dietary interventions against colon cancer will require studies in preclinical models. Many mouse models have been developed to study colon cancer but no single model can reflect all types of colon cancer in terms of molecular etiology. In addition, many models develop only low-grade cancers and are confounded by development of the disease outside of the colon. This review will discuss how mice can be used to model human colon cancer and it will describe a variety of new mouse models that develop colon-restricted cancer as well as more advanced phenotypes for studies of late-state disease.

scholarly journals Dopamine Increases the Efficacy of Anticancer Drugs in Breast and Colon Cancer Preclinical Models

2008 ◽  
Vol 14 (8) ◽  
pp. 2502-2510 ◽  
Author(s):  
Chandrani Sarkar ◽  
Debanjan Chakroborty ◽  
Uttio Roy Chowdhury ◽  
Partha Sarathi Dasgupta ◽  
Sujit Basu
Keyword(s):  
Colon Cancer ◽  
Anticancer Drugs ◽  
Preclinical Models

Preclinical Models for Chemoprevention of Colon Cancer

2003 ◽  
pp. 58-71 ◽  
Author(s):  
Eugene W. Gerner ◽  
Natalia A. Ignatenko ◽  
David G. Besselsen
Keyword(s):  
Colon Cancer ◽  
Preclinical Models

scholarly journals VEGFR2-Targeted Three-Dimensional Ultrasound Imaging Can Predict Responses to Antiangiogenic Therapy in Preclinical Models of Colon Cancer

2016 ◽  
Vol 76 (14) ◽  
pp. 4081-4089 ◽  
Author(s):  
Jianhua Zhou ◽  
Huaijun Wang ◽  
Huiping Zhang ◽  
Amelie M. Lutz ◽  
Lu Tian ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Ultrasound Imaging ◽  
Antiangiogenic Therapy ◽  
Three Dimensional ◽  
Preclinical Models

scholarly journals Why Do the Fetal Membranes Rupture Early after Fetoscopy? A Review

2021 ◽  
pp. 1-11
Author(s):  
Benjamin J. Amberg ◽  
Ryan J. Hodges ◽  
Karyn A. Rodgers ◽  
Kelly J. Crossley ◽  
Stuart B. Hooper ◽  
...  
Keyword(s):  
Fetal Surgery ◽  
Fetal Membrane ◽  
Fetal Membranes ◽  
Preclinical Models ◽  
Premature Rupture ◽  
Domestic Species ◽  
New Therapies ◽  
Preterm Premature Rupture ◽  
Limited Success ◽  
Membrane Physiology

Iatrogenic preterm premature rupture of the fetal membranes (iPPROM) remains the Achilles’ heel of keyhole fetal surgery (fetoscopy) despite significant efforts in preclinical models to develop new therapies. This limited success is partially due to incomplete understanding why the fetal membranes rupture early after fetoscopy and notable differences in membrane physiology between humans and domestic species. In this review, we summarize aspects of fetoscopy that may contribute to iPPROM, the previous efforts to develop new therapies, and limitations of preclinical models commonly used in fetal membrane research.

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