scholarly journals Neural Fate of Mesenchymal Stem Cells and Neural Crest Stem Cells: Which Ways to Get Neurons for Cell Therapy Purpose?

10.5772/53260 ◽  
2013 ◽  
Author(s):  
Virginie Neirinckx ◽  
Cecile Coste ◽  
Bernard Rogister ◽  
Sabine Wislet-
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Cell Therapy ◽  
Neural Crest ◽  
Neural Crest Stem Cells ◽  
Neural Fate

scholarly journals Adult Bone Marrow Neural Crest Stem Cells and Mesenchymal Stem Cells Are Not Able to Replace Lost Neurons in Acute MPTP-Lesioned Mice

PLoS ONE ◽  
2013 ◽  
Vol 8 (5) ◽  
pp. e64723 ◽  
Author(s):  
Virginie Neirinckx ◽  
Alice Marquet ◽  
Cécile Coste ◽  
Bernard Rogister ◽  
Sabine Wislet-Gendebien
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Neural Crest ◽  
Neural Crest Stem Cells ◽  
Adult Bone Marrow ◽  
Adult Bone

scholarly journals Mesenchymal stem cells and neural crest stem cells from adult bone marrow: characterization of their surprising similarities and differences

2012 ◽  
Vol 69 (15) ◽  
pp. 2593-2608 ◽  
Author(s):  
Sabine Wislet-Gendebien ◽  
Emerence Laudet ◽  
Virginie Neirinckx ◽  
Philippe Alix ◽  
Pierre Leprince ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Neural Crest ◽  
Neural Crest Stem Cells ◽  
Adult Bone Marrow ◽  
Similarities And Differences ◽  
Adult Bone

Placenta-derived mesenchymal stem cells for allogenic cardiac cell therapy

2012 ◽  
Vol 60 (S 01) ◽  
Author(s):  
R Roy ◽  
M Kukucka ◽  
D Messroghli ◽  
A Brodarac ◽  
M Becher ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Cell Therapy ◽  
Cardiac Cell ◽  
Cardiac Cell Therapy

Autologous transplantation of mesenchymal stem cells into the portal vein of the miniature pig; a preliminary experiment for NOTES approach

2019 ◽  
Vol 98 (9) ◽  
pp. 350-355
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Cell Therapy ◽  
Portal Vein ◽  
Liver Parenchyma ◽  
Miniature Pig ◽  
Hepatic Diseases ◽  
Study Results

Introduction: There is evidence that mesenchymal stem cells (MSCs) could trans-differentiate into the liver cells in vitro and in vivo and thus may be used as an unfailing source for stem cell therapy of liver disease. Combination of MSCs (with or without their differentiation in vitro) and minimally invasive procedures as laparoscopy or Natural Orifice Transluminal Endoscopic Surgery (NOTES) represents a chance for many patients waiting for liver transplantation in vain. Methods: Over 30 millions of autologous MSCs at passage 3 were transplanted via the portal vein in an eight months old miniature pig. The deposition of transplanted cells in liver parenchyma was evaluated histologically and the trans-differential potential of CM-DiI labeled cells was assessed by expression of pig albumin using immunofluorescence. Results: Three weeks after transplantation we detected the labeled cells (solitary, small clusters) in all 10 samples (2 samples from each lobe) but no diffuse distribution in the samples. The localization of CM-DiI+ cells was predominantly observed around the portal triads. We also detected the localization of albumin signal in CM-DiI labeled cells. Conclusion: The study results showed that the autologous MSCs (without additional hepatic differentiation in vitro) transplantation through the portal vein led to successful infiltration of intact miniature pig liver parenchyma with detectable in vivo trans-differentiation. NOTES as well as other newly developed surgical approaches in combination with cell therapy seem to be very promising for the treatment of hepatic diseases in near future.

Sign in / Sign up

Export Citation Format

Share Document