scholarly journals Impulse Oscillometric Features and Respiratory System Models Track Small Airway Function in Children

10.5772/52579 ◽  
2013 ◽  
Author(s):  
Erika G. ◽  
Homer Nazeran ◽  
Carlos Ramos ◽  
Liza Rodriguez ◽  
Lidia Rascon ◽  
...  
Keyword(s):  
Respiratory System ◽  
Small Airway ◽  
System Models ◽  
Airway Function

Effects of Medication Use on Small Airway Function and Airway Inflammation in Patients with Clinically Controlled Asthma

2021 ◽  
Vol 41 (4) ◽  
pp. 722-728
Author(s):  
Yun Li ◽  
Hong-ying Yu ◽  
Kao-chuang Zhao ◽  
Xu-hong Ding ◽  
Yi Huang ◽  
...  
Keyword(s):  
Airway Inflammation ◽  
Medication Use ◽  
Small Airway ◽  
Airway Function

scholarly journals Small airway function in obese individuals with self-reported asthma

2020 ◽  
Vol 6 (2) ◽  
pp. 00371-2019
Author(s):  
Beno W. Oppenheimer ◽  
Roberta M. Goldring ◽  
Israa Soghier ◽  
David Smith ◽  
Manish Parikh ◽  
...  
Keyword(s):  
Clinical History ◽  
Small Airway ◽  
Obese People ◽  
Airway Function ◽  
Residual Capacity ◽  
Obese Subjects ◽  
Healthy Obese ◽  
Similar Body ◽  
Metabolic Comorbidities ◽  
Asthma Group

Diagnosis of asthma in obese individuals frequently relies on clinical history, as airflow by spirometry may remain normal. This study hypothesised that obese subjects with self-reported asthma and normal spirometry will demonstrate distinct clinical characteristics, metabolic comorbidities and enhanced small airway dysfunction as compared with healthy obese subjects.Spirometry, plethysmography and oscillometry data pre/post-bronchodilator were obtained in 357 obese subjects in three groups as follows: no asthma group (n=180), self-reported asthma normal spirometry group (n=126), and asthma obstructed spirometry group (n=51). To assess the effects of obesity related to reduced lung volume, oscillometry measurements were repeated during a voluntary inflation to predicted functional residual capacity (FRC).Dyspnoea was equally prevalent in all groups. In contrast, cough, wheeze and metabolic comorbidities were more frequent in the asthma normal spirometry and asthma obstructed spirometry groups versus the no asthma group (p<0.05). Despite similar body size, oscillometry measurements demonstrated elevated R5–20 (difference between resistance at 5 and 20 Hz) in the no asthma and asthma normal spirometry groups (0.19±0.12; 0.23±0.13 kPa/(L·s−1), p<0.05) but to a lesser degree than the asthma obstructed spirometry group (0.34±0.20 kPa/(L·s−1), p<0.05). Differences between groups persisted post-bronchodilator (p<0.05). Following voluntary inflation to predicted FRC, R5–20 in the no asthma and asthma normal spirometry groups fell to similar values, indicating a reversible process (0.11±0.07; 0.12±0.08 kPa/(L·s−1), p=NS). Persistently elevated R5–20 was seen in the asthma obstructed spirometry group, suggesting chronic inflammation and/or remodelling (0.17±0.11 kPa/(L·s−1), p<0.05).Thus, small airway abnormalities of greater magnitude than observations in healthy obese people may be an early marker of asthma in obese subjects with self-reported disease despite normal airflow. Increased metabolic comorbidities in these subjects may have provided a milieu that impacted airway function.

scholarly journals Small airway function in children with mild to moderate asthmatic symptoms

2018 ◽  
Vol 121 (4) ◽  
pp. 451-457 ◽  
Author(s):  
Hanna Knihtilä ◽  
Anne Kotaniemi-Syrjänen ◽  
Anna S. Pelkonen ◽  
Mika J. Mäkelä ◽  
L. Pekka Malmberg
Keyword(s):  
Small Airway ◽  
Airway Function

Postnatal undernutrition slows development of bronchiolar epithelium in rats

1988 ◽  
Vol 255 (4) ◽  
pp. R521-R526 ◽  
Author(s):  
G. D. Massaro ◽  
L. McCoy ◽  
D. Massaro
Keyword(s):  
Small Airway ◽  
Numerical Density ◽  
Clara Cells ◽  
Ciliated Cells ◽  
Long Term Effects ◽  
Chronic Lung Diseases ◽  
Airway Function ◽  
Childhood Environment ◽  
Bronchiolar Epithelium ◽  
Morphological Maturation

The lung's small conducting airways are sites of dysfunction early in the course of chronic lung diseases that are prevalent in humans; furthermore, there is evidence that aspects of childhood environment may adversely influence small airway function in adulthood. Because there is considerable early postnatal morphological maturation of the bronchiolar epithelium in rats, these considerations led to the present study in which we assessed the effect of early postnatal undernutrition in rats on the anatomic development of the bronchiolar epithelium. We found undernutrition, produced by increasing rat litter size shortly after birth, led to delayed development of the mitochondria and rough endoplasmic reticulum of bronchiolar Clara cells. Of particular interest, underfeeding resulted in considerably diminished mitosis by Clara cells, decreased nuclear numerical density of bronchiolar ciliated cells, evidence of diminished conversion of Clara cells to ciliated cells, and an abnormal cellular composition of the small airway epithelium that persisted well beyond the period of underfeeding. We conclude that early neonatal events can have long-term effects on the bronchiolar epithelium.

scholarly journals Correlation between tests of small airway function

Thorax ◽  
1974 ◽  
Vol 29 (2) ◽  
pp. 172-178 ◽  
Author(s):  
G. M. Cochrane ◽  
S. R. Benatar ◽  
J. Davis ◽  
J. V. Collins ◽  
T. J. H. Clark
Keyword(s):  
Small Airway ◽  
Airway Function

Validity of FENO and small airway function indices in diagnosis of CVA

2017 ◽  
Author(s):  
Fengjia Chen ◽  
Xin yan Huang ◽  
Geng peng Lin ◽  
Yang li Liu ◽  
Can mao Xie ◽  
...  
Keyword(s):  
Small Airway ◽  
Airway Function

Small airway function in smokers without airway obstruction

2015 ◽  
Author(s):  
Kim Husemann ◽  
Yulia Zhukhovitskaya ◽  
Martin Kohlhäufl
Keyword(s):  
Airway Obstruction ◽  
Small Airway ◽  
Airway Function
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