Small Molecule Screens to Identify Inhibitors of Infectious Disease

The Zebrafish as a Model Host for Invasive Fungal Infections

Journal of Fungi ◽

10.3390/jof4040136 ◽

2018 ◽

Vol 4 (4) ◽

pp. 136 ◽

Cited By ~ 17

Author(s):

Emily Rosowski ◽

Benjamin Knox ◽

Linda Archambault ◽

Anna Huttenlocher ◽

Nancy Keller ◽

...

Keyword(s):

Infectious Disease ◽

Fungal Infection ◽

Small Molecule ◽

In Vivo Imaging ◽

Fungal Infections ◽

Invasive Fungal Infections ◽

Small Molecule Screening

The zebrafish has become a widely accepted model host for studies of infectious disease, including fungal infections. The species is genetically tractable, and the larvae are transparent and amenable to prolonged in vivo imaging and small molecule screening. The aim of this review is to provide a thorough introduction into the published studies of fungal infection in the zebrafish and the specific ways in which this model has benefited the field. In doing so, we hope to provide potential new zebrafish researchers with a snapshot of the current toolbox and prior results, while illustrating how the model has been used well and where the unfulfilled potential of this model can be found.

Download Full-text

Identification of Small Molecule Inhibitors of the Pathogen Box against Vibrio cholerae

Microbiology Spectrum ◽

10.1128/spectrum.00739-21 ◽

2021 ◽

Vol 9 (3) ◽

Author(s):

Haeun Kim ◽

Brianne J. Burkinshaw ◽

Linh G. Lam ◽

Kevin Manera ◽

Tao G. Dong

Keyword(s):

Public Health ◽

Infectious Disease ◽

Antibiotic Resistance ◽

Vibrio Cholerae ◽

Small Molecule ◽

Causative Agent ◽

Treatment Strategies ◽

Current Treatment ◽

Content Type ◽

Tropical Regions

Cholera is a serious infectious disease in tropical regions causing millions of infections annually. Vibrio cholerae , the causative agent of cholera, has gained multi-antibiotic resistance over the years, posing greater threat to public health and current treatment strategies. Here we report two compounds that effectively target the growth of V. cholerae and have the potential to control cholera infection.

Download Full-text

Tissue section lifting for electron microscopy

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100081292 ◽

1978 ◽

Vol 36 (2) ◽

pp. 86-87

Author(s):

Adrian F. van Dellen

Keyword(s):

Infectious Disease ◽

Electron Microscopy ◽

Tissue Culture ◽

Organ System ◽

Surrounding Tissue ◽

Paraffin Sections ◽

Surface Areas ◽

Specific Determination ◽

High Degree ◽

Accuracy And Repeatability

The morphologic pathologist may require information on the ultrastructure of a non-specific lesion seen under the light microscope before he can make a specific determination. Such lesions, when caused by infectious disease agents, may be sparsely distributed in any organ system. Tissue culture systems, too, may only have widely dispersed foci suitable for ultrastructural study. In these situations, when only a few, small foci in large tissue areas are useful for electron microscopy, it is advantageous to employ a methodology which rapidly selects a single tissue focus that is expected to yield beneficial ultrastructural data from amongst the surrounding tissue. This is in essence what "LIFTING" accomplishes. We have developed LIFTING to a high degree of accuracy and repeatability utilizing the Microlift (Fig 1), and have successfully applied it to tissue culture monolayers, histologic paraffin sections, and tissue blocks with large surface areas that had been initially fixed for either light or electron microscopy.

Download Full-text

Indian vultures: victims of an infectious disease epidemic?

Animal Conservation ◽

10.1017/s136794300300324x ◽

2003 ◽

Vol 6 (3) ◽

pp. 189-197 ◽

Cited By ~ 23

Author(s):

A. A. Cunningham ◽

V. Prakash ◽

D. Pain ◽

G. R. Ghalsasi ◽

G. A. H. Wells ◽

...

Keyword(s):

Infectious Disease

Download Full-text

A privileged ternary blend enabling non-fullerene organic photovoltaics with over 14% efficiency

Journal of Materials Chemistry C ◽

10.1039/d0tc02778b ◽

2020 ◽

Vol 8 (43) ◽

pp. 15135-15141

Author(s):

Jing Yan ◽

Yuan-Qiu-Qiang Yi ◽

Jianqi Zhang ◽

Huanran Feng ◽

Yanfeng Ma ◽

...

Keyword(s):

Small Molecule ◽

Organic Photovoltaics ◽

Power Conversion ◽

Ternary Blend ◽

Conversion Efficiencies

Two non-fullerene small molecule acceptors, NT-4F and NT-4Cl, were designed and synthesized. Power conversion efficiencies of 11.44% and 14.55% were achieved for NT-4Cl-based binary and ternary devices, respectively.

Download Full-text