scholarly journals Histaminergic Modulation of Body Temperature and Energy Expenditure

Hyperthermia ◽  
10.5772/52400 ◽  
2013 ◽  
Author(s):  
Iustin V.
Keyword(s):  
Body Temperature ◽  
Energy Expenditure

Ambient temperature effects on physiological traits of white-tailed deer

1975 ◽  
Vol 53 (6) ◽  
pp. 679-685 ◽  
Author(s):  
J. B. Holter ◽  
W. E. Urban Jr. ◽  
H. H. Hayes ◽  
H. Silver ◽  
H. R. Skutt
Keyword(s):  
Heart Rate ◽  
Body Temperature ◽  
Energy Expenditure ◽  
Ambient Temperature ◽  
Temperature Effects ◽  
Temperature Changes ◽  
Wind Chill ◽  
Ambient Temperatures ◽  
Energy Equilibrium ◽  
Body Energy

Six adult white-tailed deer (Odocoileus virginianus borealis) were exposed to 165 periods of 12 consecutive hours of controlled constant ambient temperature in an indirect respiration calorimeter. Temperatures among periods varied from 38 to 0 (summer) or to −20C (fall, winter, spring). Traits measured were energy expenditure (metabolic rate), proportion of time spent standing, heart rate, and body temperature, the latter two using telemetry. The deer used body posture extensively as a means of maintaining body energy equilibrium. Energy expenditure was increased at low ambient temperature to combat cold and to maintain relatively constant body temperature. Changes in heart rate paralleled changes in energy expenditure. In a limited number of comparisons, slight wind chill was combatted through behavioral means with no effect on energy expenditure. The reaction of deer to varying ambient temperatures was not the same in all seasons of the year.

scholarly journals The metabolic response of the Bradypus sloth to temperature

PeerJ ◽  
2018 ◽  
Vol 6 ◽  
pp. e5600 ◽  
Author(s):  
Rebecca Naomi Cliffe ◽  
David Michael Scantlebury ◽  
Sarah Jane Kennedy ◽  
Judy Avey-Arroyo ◽  
Daniel Mindich ◽  
...  
Keyword(s):  
Oxygen Consumption ◽  
Body Temperature ◽  
Energy Expenditure ◽  
High Power ◽  
Metabolic Response ◽  
Metabolic Responses ◽  
Metabolic Depression ◽  
Wide Range ◽  
Energetic Constraints ◽  
Power Costs

Poikilotherms and homeotherms have different, well-defined metabolic responses to ambient temperature (Ta), but both groups have high power costs at high temperatures. Sloths (Bradypus) are critically limited by rates of energy acquisition and it has previously been suggested that their unusual departure from homeothermy mitigates the associated costs. No studies, however, have examined how sloth body temperature and metabolic rate vary with Ta. Here we measured the oxygen consumption (VO2) of eight brown-throated sloths (B. variegatus) at variable Ta’s and found that VO2 indeed varied in an unusual manner with what appeared to be a reversal of the standard homeotherm pattern. Sloth VO2 increased with Ta, peaking in a metabolic plateau (nominal ‘thermally-active zone’ (TAZ)) before decreasing again at higher Ta values. We suggest that this pattern enables sloths to minimise energy expenditure over a wide range of conditions, which is likely to be crucial for survival in an animal that operates under severe energetic constraints. To our knowledge, this is the first evidence of a mammal provisionally invoking metabolic depression in response to increasing Ta’s, without entering into a state of torpor, aestivation or hibernation.

scholarly journals SAT-LB107 Insulin Sensing by Astrocytes Is Critical for Normal Thermogenesis and Body Temperature Regulation

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Jennifer Wootton Hill ◽  
Iyad H Manaserh
Keyword(s):  
Body Temperature ◽  
Energy Expenditure ◽  
Insulin Signaling ◽  
Insulin Receptors ◽  
Normal Body Temperature ◽  
Metabolic Dysregulation ◽  
Brown Adipose ◽  
Novel Target ◽  
Thermogenic Response

Abstract The important role of astrocytes in the central control of energy balance and glucose homeostasis has only recently been recognized. Changes in thermoregulation can lead to metabolic dysregulation, but the role of astrocytes in this process is not yet clear. Therefore, we generated mice congenitally lacking insulin receptors (IR) in astrocytes (IRKOGFAP mice) to investigate the involvement of astrocyte insulin signaling. IRKOGFAP mice displayed a significant decrease in energy expenditure and a striking decrease in basal and fasting body temperature. When exposed to cold, however, they were able to mount a thermogenic response. Brown adipose tissue in IRKOGFAP mice exhibited increased adipocyte size, more apoptosis, loss of innervation, and decreased βAR3 expression levels. These findings identify a novel role for astrocyte insulin signaling in the development of normal body temperature control and sympathetic activation of BAT. Targeting insulin signaling in astrocytes has the potential to serve as a novel target for increasing energy expenditure.

scholarly journals 18F-FDG uptake in the colon is modulated by metformin but not associated with core body temperature and energy expenditure

PLoS ONE ◽  
2017 ◽  
Vol 12 (5) ◽  
pp. e0176242 ◽  
Author(s):  
Lonneke Bahler ◽  
Frits Holleman ◽  
Man-Wai Chan ◽  
Jan Booij ◽  
Joost B. Hoekstra ◽  
...  
Keyword(s):  
Body Temperature ◽  
Energy Expenditure ◽  
Core Body Temperature ◽  
Fdg Uptake ◽  
18F Fdg ◽  
Core Body

scholarly journals Individual differences in body temperature and the relation to energy expenditure: the influence of mild cold

2001 ◽  
Vol 26 (4-5) ◽  
pp. 455-459 ◽  
Author(s):  
A.M.J. van Ooijen ◽  
W.D. van Marken Lichtenbelt ◽  
K.R. Westerterp
Keyword(s):  
Individual Differences ◽  
Body Temperature ◽  
Energy Expenditure

scholarly journals Preoptic leptin signaling modulates energy balance independent of body temperature regulation

eLife ◽  
2018 ◽  
Vol 7 ◽  
Author(s):  
Sangho Yu ◽  
Helia Cheng ◽  
Marie François ◽  
Emily Qualls-Creekmore ◽  
Clara Huesing ◽  
...  
Keyword(s):  
Body Weight ◽  
Energy Balance ◽  
Body Temperature ◽  
Energy Expenditure ◽  
Ambient Temperature ◽  
Temperature Regulation ◽  
Leptin Receptor ◽  
Energy State ◽  
Body Temperature Regulation ◽  
Leptin Signaling

The adipokine leptin acts on the brain to regulate energy balance but specific functions in many brain areas remain poorly understood. Among these, the preoptic area (POA) is well known to regulate core body temperature by controlling brown fat thermogenesis, and we have previously shown that glutamatergic, long-form leptin receptor (Lepr)-expressing neurons in the POA are stimulated by warm ambient temperature and suppress energy expenditure and food intake. Here we further investigate the role of POA leptin signaling in body weight regulation and its relationship to body temperature regulation in mice. We show that POA Lepr signaling modulates energy expenditure in response to internal energy state, and thus contributes to body weight homeostasis. However, POA leptin signaling is not involved in ambient temperature-dependent metabolic adaptations. Our study reveals a novel cell population through which leptin regulates body weight.

scholarly journals Physiological and cognitive consequences of a daily 26h photoperiod in a primate (M. murinus)

2020 ◽  
Author(s):  
Clara Hozer ◽  
Fabien Pifferi
Keyword(s):  
Oxidative Stress ◽  
Body Temperature ◽  
Energy Expenditure ◽  
Cycle Length ◽  
Resonance Theory ◽  
Marginal Costs ◽  
Natural Photoperiod ◽  
Energetic Expenditure ◽  
First Time ◽  
Over Time

AbstractDaily resetting of the circadian clock to the 24h natural photoperiod might induce marginal costs that would accumulate over time and forward affect fitness. It was proposed as the circadian resonance theory by Pittendrigh in 1972. For the first time, we aimed to evaluate these physiological and cognitive costs that would partially explain the mechanisms of the circadian resonance hypothesis. We evaluated the potential costs of imposing a 26h photoperiodic regimen compared to the classical 24h entrainment measuring several physiological and cognitive parameters (body temperature, energetic expenditure, oxidative stress, cognitive performances). We found significant higher resting body temperature and energy expenditure and lower cognitive performances when the photoperiodic cycle length was 26h. Together these results suggest that a great deviation of external cycles from 24h leads to daily greater synchronization costs, and lower cognitive capacities. To our knowledge, this study is the first to highlight potential mechanisms of circadian resonance theory.

scholarly journals Leptin Receptor Signaling in Sim1-Expressing Neurons Regulates Body Temperature and Adaptive Thermogenesis

Endocrinology ◽  
2019 ◽  
Vol 160 (4) ◽  
pp. 863-879 ◽  
Author(s):  
Isin Cakir ◽  
Myriam Diaz-Martinez ◽  
Pauline Lining Pan ◽  
E Brian Welch ◽  
Sachin Patel ◽  
...  
Keyword(s):  
Body Temperature ◽  
Energy Expenditure ◽  
Molecular Mechanisms ◽  
Leptin Receptor ◽  
Uncoupling Protein ◽  
Gene Copy ◽  
Adaptive Thermogenesis ◽  
Brown Adipose ◽  
Core Body

Abstract Leptin signals to regulate food intake and energy expenditure under conditions of normative energy homeostasis. The central expression and function of leptin receptor B (LepRb) have been extensively studied during the past two decades; however, the mechanisms by which LepRb signaling dysregulation contributes to the pathophysiology of obesity remains unclear. The paraventricular nucleus of the hypothalamus (PVN) plays a crucial role in regulating energy balance as well as the neuroendocrine axes. The role of LepRb expression in the PVN in regard to the regulation of physiological function of leptin has been controversial. The single-minded homolog 1 gene (Sim1) is densely expressed in the PVN and in parts of the amygdala, making Sim1-Cre mice a useful model for examining molecular mechanisms regulating PVN function. In this study, we characterized the physiological role of LepRb in Sim1-expressing neurons using LepRb-floxed × Sim1-Cre mice. Sim1-specific LepRb-deficient mice were surprisingly hypophagic on regular chow but gained more weight upon exposure to a high-fat diet than did their control littermates. We show that Sim1-specific deletion of a single LepRb gene copy caused decreased surface and core body temperatures as well as decreased energy expenditure in ambient room temperatures in both female and male mice. Furthermore, cold-induced adaptive (nonshivering) thermogenesis is disrupted in homozygous knockout mice. A defective thermoregulatory response was associated with defective cold-induced upregulation of uncoupling protein 1 in brown adipose tissue and reduced serum T4. Our study provides novel functional evidence supporting LepRb signaling in Sim1 neurons in the regulation of body weight, core body temperature, and cold-induced adaptive thermogenesis.

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