scholarly journals Chromosomal Analysis: Clinical Applicability to Brain Cancers

10.5772/52354 ◽  
2013 ◽  
Author(s):  
Fabio P. Estumano da Silva ◽  
Edivaldo H. C. de Oliveir
Keyword(s):  
Chromosomal Analysis ◽  
Clinical Applicability

Quality of cytogenetic investigations: problems and ways for improvement

2020 ◽  
pp. 22-24
Author(s):  
В.Г. Антоненко ◽  
Н.В. Шилова ◽  
Е.Н. Лукаш ◽  
Э.Р. Бабкеева ◽  
В.Н. Малахов
Keyword(s):  
Quality Assessment ◽  
Russian Federation ◽  
Chromosomal Analysis ◽  
Common Causes

Представлены результаты экспертной оценки качества цитогенетических исследований в лабораториях РФ в системе межлабораторных сличительных испытаний «ФСВОК» в 2018-2019 гг. Обсуждаются наиболее частые причины неудовлетворительных результатов экспертизы и возможные пути улучшения качества цитогенетических исследований. We report the results of quality assessment for preparation of cytogenetic slides and chromosomal analysis in the laboratories of Russian Federation in the system of the interlaboratory comparative examinations “FSVOK” in 2018-2019. Common causes of poor results of assessment and the ways for improvement of quality for cytogenetic investigations are discussed.

Aplicabilidade clínica das técnicas de liberação manual diafragmática: uma revisão sistemática

2020 ◽  
Vol 18 (3) ◽  
pp. 111-116
Author(s):  
Dulce Marieli Danieli ◽  
Fabíola De Almeida Gomes ◽  
Bruna Eibel ◽  
William Dhein
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Gastroesophageal Reflux ◽  
Randomized Clinical Trials ◽  
Experimental Studies ◽  
Scar Tissue ◽  
Low Back ◽  
Musculoskeletal Manipulations ◽  
Clinical Applicability ◽  
Quasi Experimental

INTRODUÇÃO: O diafragma é o principal músculo respiratório e desempenha um papel importante na respiração e na regulação fisiológica. Uma terapia que visa melhorar essas condições referentes ao diafragma, é a técnica de liberação manual diafragmática. OBJETIVO: O objetivo deste estudo foi verificar a aplicabilidade clínica das técnicas manuais de liberação diafragmática e identificar as principais técnicas, populações investigadas, variáveis avaliadas e seus desfechos. MÉTODOS: Foram pesquisadas as seguintes bases de dados: PubMed, Scielo e Science Direct, com os descritores “Diaphragm [Mesh]” e “Musculoskeletal Manipulations [Mesh]” com seus correspondentes no mesmo idioma. Foram incluídos ensaios clínicos randomizados, não randomizados, estudos semi, quase-experimentais e estudos pilotos ou de caso, que abordaram técnicas de liberação manuais diafragmáticas.RESULTADOS: Há variadas técnicas de liberação diafragmática, sendo as mais mencionadas: normalização dos pilares do diafragma, alongamento e estiramento do diafragma, relaxamento dos pilares do diafragma. Além disso, as técnicas de liberação diafragmática vêm sendo associadas a protocolos de terapia manipulativa osteopática (TMO). As principais populações estudadas foram de pacientes saudáveis, com lombalgia, cervicalgia, osteoartrite, asmáticos, doença pulmonar obstrutiva crônica, constipados, cardiopatas e com refluxo gastroesofágico. Os principais desfechos avaliados são variáveis musculoesqueléticas (dor, flexibilidade, amplitude, espessura diafragmática), variáveis cardiorrespiratórias (pressão inspiratória/expiratória máxima (PImax e Pemax), mobilidade torácica, frequência cardíaca e respiratória), qualidade de vida e disfunções gastrointestinais/gastroesofágicas. CONCLUSÃO: A aplicabilidade clínica das técnicas de liberação diagramática está sendo investigada associado com outras técnicas osteopáticas, em protocolos de TMO em pacientes saudáveis, pneumopatas, cardiopatas, gestantes, em cicatriz pós-cirúrgica, constipados, com refluxo gastroesofágico, osteoartrite, cervicalgia e com lombalgia. Evidencia-se: diminuição ou eliminação das dores musculoesqueléticas, aumento da flexibilidade, ADM, Pimáx e Pemáx, aumento da mobilidade torácica, aumento da qualidade de vida, diminuição do inchaço e dor abdominal e sem efeito em cardiopatas.ABSTRACT. Clinical applicability of manual diaphragmatic release techniques: a systematic review.BACKGROUND: The diaphragm is the main respiratory muscle and plays an important role in breathing and physiological regulation. A therapy that aims to improve these conditions regarding the diaphragm, is the manual diaphragmatic release technique.OBJECTIVE: The aim of this study was to verify the clinical applicability of manual diaphragmatic release techniques and searching the main techniques, population, evaluated variables, and outcomes. METHODS: The following electronic databases were searched: PubMed, Scielo, and Science Direct, with the descriptors “Diaphragm [Mesh]” and “Musculoskeletal Manipulations [Mesh]” with their correspondents in the same language. There were included randomized clinical trial, non-randomized clinical trials, semi, and quasi-experimental studies, and pilot or case studies, which addressed manual diaphragmatic release techniques.RESULTS: There are various diaphragmatic release techniques, the most mentioned are: normalization of the diaphragm pillars, stretching of the diaphragm, relaxation of the diaphragm pillars, and protocols for osteopathic manipulative therapy (OMT) for the diaphragm. The main populations studied were healthy patients, with low back pain, asthmatics, chronic pulmonary obstructive disease, constipated, cardiac patients, and gastroesophageal reflux. The main outcomes assessed are musculoskeletal variables (pain, flexibility, range of motion, diaphragmatic thickness), cardiorespiratory variables (maximal inspiratory/expiratory pressure (MIP and MEP), chest mobility, heart, and respiratory rate), quality of life, and gastrointestinal/ gastroesophageal disorders.CONCLUSION: The clinical applicability of diagrammatic release techniques is being investigated in association with other osteopathic techniques, in protocols of OMT in healthy subjects, patients with lung diseases, heart disease, pregnant women, scar tissue, constipated, with gastroesophageal reflux, osteoarthritis, cervicalgia and with low back pain. There is evidence of reduction and elimination of musculoskeletal pain, increased MIP, increased chest mobility, an increase in health quality, a decrease of bloating and abdominal pain related to constipation, and a decrease of reflux symptoms.

Recent Nano-based Therapeutic Intervention of Bioactive Sesquiterpenes: Prospects in Cancer Therapeutics

2020 ◽  
Vol 26 (11) ◽  
pp. 1138-1144 ◽  
Author(s):  
Mohammad A. Ansari ◽  
Khan F. Badrealam ◽  
Asrar Alam ◽  
Saba Tufail ◽  
Gulshan Khalique ◽  
...  
Keyword(s):  
Physicochemical Properties ◽  
Essential Oils ◽  
Plant Species ◽  
Bioactive Compounds ◽  
Therapeutic Intervention ◽  
Cancer Therapeutics ◽  
Therapeutic Interventions ◽  
Pharmacological Intervention ◽  
Clinical Applicability ◽  
Near Future

: In the recent scenario, nanotechnology-based therapeutics intervention has gained tremendous impetus all across the globe. Nano-based pharmacological intervention of various bioactive compounds has been explored on an increasing scale. Sesquiterpenes are major constituents of essential oils (EOs) present in various plant species which possess intriguing therapeutic potentials. However, owing to their poor physicochemical properties; they have pharmacological limitations. Recent advances in nano-based therapeutic interventions offer various avenues to improve their therapeutic applicability. Reckoning with these, the present review collates various nano-based therapeutic intervention of sesquiterpenes with prospective potential against various debilitating diseases especially cancer. In our viewpoint, considering the burgeoning advancement in the field of nanomedicine; in the near future, the clinical applicability of these nano-formulated sesquiterpenes can be foreseen with great enthusiasm.

A VALIDATION, WITH NEW CLINICAL APPLICABILITY, OF A CLINICAL-GENETIC RISK MODEL THAT PREDICTS THROMBOSIS WITH HIGH SENSITIVITY IN PATIENTS WITH LYMPHOMA

2019 ◽  
Vol 37 ◽  
pp. 534-534
Author(s):  
M. Bastos-Oreiro ◽  
J. Ortiz ◽  
V. Pradillo ◽  
C. Martinez-Laperche ◽  
E. Salas ◽  
...  
Keyword(s):  
Genetic Risk ◽  
Risk Model ◽  
High Sensitivity ◽  
Clinical Genetic ◽  
Clinical Applicability

A NOTE ON KIDWELL'S CHROMOSOMAL ANALYSIS OF EGG PRODUCTION AND CHAETA NUMBER IN DROSOPHILA MELANOGASTER

1970 ◽  
Vol 12 (2) ◽  
pp. 356-358 ◽  
Author(s):  
P. Glaser ◽  
J. F. Kldwell
Keyword(s):  
Drosophila Melanogaster ◽  
Egg Production ◽  
Genetic Variance ◽  
Chromosomal Analysis ◽  
Epistatic Variance

An earlier paper (Kidwell, J.F., 1969, Can. J. Genet. Cytol 11: 547-557) has described partitioning of the genetic variance of egg production and chaeta number in Drosophila melanogaster, assuming equal frequencies of all chromosomes. Kidwell's data were analyzed again, and the new analyses were based on several panmictic populations with varying frequencies for each genotype. The importances of the several portions of the genetic variance were estimated for each population; several cases are presented. In most cases the ranges were substantial, especially those of the dominance and four-factor epistatic variances. The results of the present study generally support Kidwell's previous conclusions and suggest that epistatic variance should not routinely be assumed negligible.

Investigation of automated sleep staging from cardiorespiratory signals regarding clinical applicability and robustness

2022 ◽  
Vol 71 ◽  
pp. 103047
Author(s):  
Miriam Goldammer ◽  
Sebastian Zaunseder ◽  
Moritz D. Brandt ◽  
Hagen Malberg ◽  
Felix Gräßer
Keyword(s):  
Sleep Staging ◽  
Clinical Applicability
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