Pancreatic Islet Beta-Cell Apoptosis in Experimental Diabetes Mellitus

10.5772/51411 ◽  
2012 ◽  
Author(s):  
A.V. Smirnov ◽  
G.L. Snigur ◽  
M.P. Voronkov
Keyword(s):  
Diabetes Mellitus ◽  
Beta Cell ◽  
Pancreatic Islet ◽  
Cell Apoptosis ◽  
Experimental Diabetes ◽  
Beta Cell Apoptosis ◽  
Experimental Diabetes Mellitus ◽  
Islet Beta Cell ◽  
Pancreatic Islet Beta Cell

scholarly journals Variability of the pancreatic islet beta cell/liver (GLUT 2) glucose transporter gene in NIDDM patients

Diabetologia ◽  
1994 ◽  
Vol 37 (4) ◽  
pp. 420-427 ◽  
Author(s):  
Y. Tanizawa ◽  
A. C. Riggs ◽  
J. M. Roseman ◽  
M. A. Permutt ◽  
K. C. Chiu ◽  
...  
Keyword(s):  
Beta Cell ◽  
Pancreatic Islet ◽  
Glucose Transporter ◽  
Transporter Gene ◽  
Islet Beta Cell ◽  
Pancreatic Islet Beta Cell ◽  
Niddm Patients

scholarly journals THE ROLE OF SURVIVIN AND RAF-1 KINASE AGAINST ENHANCEMENT OF PANCREATIC BETA-CELL APOPTOSIS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS

2018 ◽  
Vol 11 (11) ◽  
pp. 344
Author(s):  
Eva Decroli ◽  
Asman Manaf ◽  
Syafril Syahbuddin ◽  
Sarwono Waspadji ◽  
Dwisari Dillasamola
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Beta Cell ◽  
Cell Apoptosis ◽  
Pancreatic Beta Cell ◽  
Enzyme Linked Immunosorbent Assay ◽  
Beta Cell Apoptosis

Objective: This study aimed to reveal differences in levels of survivin and Raf-1 kinase in prediabetes, controlled Type 2 diabetes mellitus (T2DM), uncontrolled T2DM, and their relationship with hemoglobin A1c (HbA1c) levels and serum triglyceride levels.Methods: This study was an observational study with a cross-sectional design. The study involved 60 people with T2DM who visited the endocrine and metabolic clinic and 30 prediabetes patients. The variables were survivin levels and Raf-1 kinase enzymes that examined using enzyme-linked immunosorbent assay techniques. HbA1c values are measured by high-performance liquid chromatography and triglyceride levels measured by enzymatic method.Results: Average levels of Raf-1 kinase were significantly higher in the prediabetes group, controlled T2DM, and uncontrolled T2DM (11.6±1.4 pg mL, 9.9±1.1 pg/mL, and 9.1±1.5 pg/mL). Survivin was significantly higher in the prediabetes group, controlled T2DM, and uncontrolled T2DM (5.4±0.4 pg mL, 5.0±0.2 pg/mL, and 4.7±0.1 pg/mL). There was no correlation between HbA1c with Raf-1 kinase levels (R=−0.215, p=0.250), but there was a correlation between HbA1c with serum survivin levels (R=−0.6, *p<0.05). There was a correlation between the levels of triglycerides with survivin but not with Raf-1 kinase (R=−0.267, *p=0.039).Conclusion: Survivin and Raf-1 kinase levels are lower in uncontrolled T2DM. This explained the role of survivin and Raf-1 kinase against enhancement of pancreatic beta-cell apoptosis in patients with T2DM.

Glutamate is not a Major Conveyer of ATP-sensitive K+ Channel-Independent Glucose Action in Pancreatic Islet .BETA. Cell.

2001 ◽  
Vol 48 (3) ◽  
pp. 391-395 ◽  
Author(s):  
SATOKO YAMADA ◽  
MITSUHISA KOMATSU ◽  
YOSHIHIKO SATO ◽  
KEISHI YAMAUCHI ◽  
TORU AIZAWA ◽  
...  
Keyword(s):  
Beta Cell ◽  
Pancreatic Islet ◽  
K Channel ◽  
Islet Beta Cell ◽  
Pancreatic Islet Beta Cell
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