scholarly journals Mono-Ubiquitination of Nuclear Annexin A1 and Mutagenesis

Mutagenesis ◽  
10.5772/50800 ◽  
2012 ◽  
Author(s):  
Fusao Hirata ◽  
George B. ◽  
Aiko Hirat
Keyword(s):  
Annexin A1

Efficacy of Annexin A1 Immunostaining in Bone Marrow for the Diagnosis of Hairy Cell Leukemia

2019 ◽  
Vol 9 (4) ◽  
pp. 236
Author(s):  
Chang-Hun Park ◽  
Hyun-Young Kim ◽  
Sang-Yong Shin ◽  
Hee-Jin Kim ◽  
Chul Won Jung ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Hairy Cell Leukemia ◽  
Annexin A1 ◽  
Hairy Cell ◽  
Cell Leukemia

Investigating the role of Annexin A1 in Adipogenesis and its ability to dampen Obesity associated Inflammation

2017 ◽  
Author(s):  
Sehar Sajid ◽  
Derek Renshaw ◽  
Bernard Burke ◽  
Christopher Mee
Keyword(s):  
Annexin A1

scholarly journals Annexin-A1 SUMOylation regulates microglial polarization after cerebral ischemia by modulating IKKα stability via selective autophagy

2021 ◽  
Vol 7 (4) ◽  
pp. eabc5539
Author(s):  
Xing Li ◽  
Qian Xia ◽  
Meng Mao ◽  
Huijuan Zhou ◽  
Lu Zheng ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Underlying Mechanism ◽  
Nuclear Factor Κb ◽  
Annexin A1 ◽  
Selective Autophagy ◽  
Microglial Polarization ◽  
Proinflammatory Mediators ◽  
Therapeutic Benefits ◽  
Iκb Kinase ◽  
Ikk Complex

Annexin-A1 (ANXA1) has recently been proposed to play a role in microglial activation after brain ischemia, but the underlying mechanism remains poorly understood. Here, we demonstrated that ANXA1 is modified by SUMOylation, and SUMOylated ANXA1 could promote the beneficial phenotype polarization of microglia. Mechanistically, SUMOylated ANXA1 suppressed nuclear factor κB activation and the production of proinflammatory mediators. Further study revealed that SUMOylated ANXA1 targeted the IκB kinase (IKK) complex and selectively enhanced IKKα degradation. Simultaneously, we detected that SUMOylated ANXA1 facilitated the interaction between IKKα and NBR1 to promote IKKα degradation through selective autophagy. Further work revealed that the overexpression of SUMOylated ANXA1 in microglia/macrophages resulted in marked improvement in neurological function in a mouse model of cerebral ischemia. Collectively, our study demonstrates a previously unidentified mechanism whereby SUMOylated ANXA1 regulates microglial polarization and strongly indicates that up-regulation of ANXA1 SUMOylation in microglia may provide therapeutic benefits for cerebral ischemia.

scholarly journals The role and mechanism of the annexin A1 peptide Ac2‐26 in rats with cardiopulmonary bypass lung injury

2021 ◽  
Author(s):  
Jiyang Xu ◽  
Chengkun Yu ◽  
Junli Luo ◽  
Yuhan Guo ◽  
Chi Cheng ◽  
...  
Keyword(s):  
Cardiopulmonary Bypass ◽  
Lung Injury ◽  
Annexin A1

scholarly journals Annexin A1: shifting the balance towards resolution and repair

2016 ◽  
Vol 397 (10) ◽  
pp. 971-979 ◽  
Author(s):  
Giovanna Leoni ◽  
Asma Nusrat
Keyword(s):  
Immune Cells ◽  
Lipid Mediators ◽  
Annexin A1 ◽  
Repair Mechanisms ◽  
Mucosal Homeostasis ◽  
Epithelial Barriers

Abstract Epithelial barriers play an important role in regulating mucosal homeostasis. Upon injury, the epithelium and immune cells orchestrate repair mechanisms that re-establish homeostasis. This process is highly regulated by protein and lipid mediators such as Annexin A1 (ANXA1). In this review, we focus on the pro-repair properties of ANXA1.

The role of annexin A1 in Candida albicans and Candida auris infections in murine neutrophils

2021 ◽  
Vol 150 ◽  
pp. 104689
Author(s):  
José Marcos Sanches ◽  
Luana Rossato ◽  
Izabella Lice ◽  
Anna Maria Alves de Piloto Fernandes ◽  
Gustavo Henrique Bueno Duarte ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Annexin A1 ◽  
Candida Auris
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