Viscoelastic Properties of the Human Dermis and Other Connective Tissues and Its Relevance to Tissue Aging and Aging–Related Disease

Viscoelastic properties of acid- and alkaline-treated human dermis: a correlation between total surface charge and elastic modulus

Skin Research and Technology ◽

10.1111/j.0909-752x.2006.00150.x ◽

2006 ◽

Vol 12 (3) ◽

pp. 190-198 ◽

Cited By ~ 20

Author(s):

Gurinder P. Seehra ◽

Frederick H. Silver

Keyword(s):

Elastic Modulus ◽

Surface Charge ◽

Viscoelastic Properties ◽

Human Dermis

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Viscoelastic Properties of Spine Ligament Collagen Fascicles

ASME 2008 Summer Bioengineering Conference, Parts A and B ◽

10.1115/sbc2008-192643 ◽

2008 ◽

Author(s):

Scott R. Lucas ◽

Robert S. Salzar ◽

Cameron R. Bass

Keyword(s):

Viscoelastic Properties ◽

Volume Fraction ◽

Material Model ◽

Ground Substance ◽

Connective Tissues ◽

Model Based

Connective tissues, such as ligaments and tendons, are comprised of varying amounts of collagen, elastin, and ground substance. It is conceivable to develop a microstructural material model based on the volume fraction and orientation of each constituent, and their interactions.

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Viscoelastic properties of young and old human dermis: A proposed molecular mechanism for elastic energy storage in collagen and elastin

Journal of Applied Polymer Science ◽

10.1002/app.11119 ◽

2002 ◽

Vol 86 (8) ◽

pp. 1978-1985 ◽

Cited By ~ 56

Author(s):

Frederick H. Silver ◽

Gurinder P. Seehra ◽

Joseph W. Freeman ◽

Dale DeVore

Keyword(s):

Energy Storage ◽

Molecular Mechanism ◽

Elastic Energy ◽

Viscoelastic Properties ◽

Human Dermis

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Collagen networks determine viscoelastic properties of connective tissues yet do not hinder diffusion of the aqueous solvent

Soft Matter ◽

10.1039/c8sm02264j ◽

2019 ◽

Vol 15 (14) ◽

pp. 3055-3064 ◽

Cited By ~ 15

Author(s):

Frank Sauer ◽

Linda Oswald ◽

Angela Ariza de Schellenberger ◽

Heiko Tzschätzsch ◽

Felix Schrank ◽

...

Keyword(s):

Power Law ◽

Viscoelastic Properties ◽

Collagen Gels ◽

Connective Tissues ◽

Aqueous Solvent

Novel tabletop MRE reveals loss of viscoelastic power law behavior in structurally unchanged collagen gels after intrafibrillar crosslinking.

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Pan-tissue aging clock genes that have intimate connections with the immune system and age-related disease

Rejuvenation Research ◽

10.1089/rej.2021.0012 ◽

2021 ◽

Author(s):

Adiv A Johnson ◽

Maxim Shokhirev

Keyword(s):

Immune System ◽

Clock Genes ◽

Related Disease ◽

Age Related ◽

Tissue Aging

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Banded Structures in the Connective Tissue of Meningioma

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100091159 ◽

1976 ◽

Vol 34 ◽

pp. 234-235

Author(s):

C. N. Sun ◽

H. J. White

Keyword(s):

Connective Tissue ◽

Osmium Tetroxide ◽

Uranyl Acetate ◽

Collagen Fibrils ◽

Lead Citrate ◽

Connective Tissues ◽

Native Collagen ◽

Routine Procedures

Previously, we have reported on extracellular cross-striated banded structures in human connective tissues of a variety of organs (1). Since then, more material has been examined and other techniques applied. Recently, we studied a fibrocytic meningioma of the falx. After the specimen was fixed in 4% buffered glutaraldehyde and post-fixed in 1% buffered osmium tetroxide, other routine procedures were followed for embedding in Epon 812. Sections were stained with uranyl acetate and lead citrate. There were numerous cross striated banded structures in aggregated bundle forms found in the connecfive tissue of the tumor. The banded material has a periodicity of about 450 Å and where it assumes a filamentous arrangement, appears to be about 800 Å in diameter. In comparison with the vicinal native collagen fibrils, the banded material Is sometimes about twice the diameter of native collagen.

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Relationships between hierarchical structure and properties in macromolecular systems

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100126950 ◽

1987 ◽

Vol 45 ◽

pp. 440-443

Author(s):

E. Baer

Keyword(s):

Uniaxial Tension ◽

Hierarchical Structure ◽

Inorganic Material ◽

Hierarchical Structures ◽

Bone Collagen ◽

Structure And Properties ◽

Connective Tissues ◽

Scale Level ◽

Fibrous Protein ◽

Macromolecular Systems

The most advanced macromolecular materials are found in plants and animals, and certainly the connective tissues in mammals are amongst the most advanced macromolecular composites known to mankind. The efficient use of collagen, a fibrous protein, in the design of both soft and hard connective tissues is worthy of comment. Very crudely, in bone collagen serves as a highly efficient binder for the inorganic hydroxyappatite which stiffens the structure. The interactions between the organic fiber of collagen and the inorganic material seem to occur at the nano (scale) level of organization. Epitatic crystallization of the inorganic phase on the fibers has been reported to give a highly anisotropic, stress responsive, structure. Soft connective tissues also have sophisticated oriented hierarchical structures. The collagen fibers are “glued” together by a highly hydrated gel-like proteoglycan matrix. One of the simplest structures of this type is tendon which functions primarily in uniaxial tension as a reinforced elastomeric cable between muscle and bone.

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