scholarly journals Recent Advances in Ocular Nucleic Acid-Based Therapies: The Silent Era

10.5772/48454 ◽  
2012 ◽  
Author(s):  
Covadonga Paeda ◽  
Tamara Martnez ◽  
Natalia Wright ◽  
Ana Isabel
Keyword(s):  
Nucleic Acid ◽  
Recent Advances ◽  
Silent Era

scholarly journals Nanomaterials for molecular signal amplification in electrochemical nucleic acid biosensing: recent advances and future prospects for point-of-care diagnostics

2020 ◽  
Vol 5 (1) ◽  
pp. 49-66 ◽  
Author(s):  
Léonard Bezinge ◽  
Akkapol Suea-Ngam ◽  
Andrew J. deMello ◽  
Chih-Jen Shih
Keyword(s):  
Nucleic Acid ◽  
Molecular Diagnostics ◽  
Signal Amplification ◽  
Point Of Care ◽  
Future Prospects ◽  
Electrochemical Biosensing ◽  
Recent Advances ◽  
Point Of Care Diagnostics ◽  
Molecular Signal

This account reviews the major amplification strategies utilizing nanomaterials in electrochemical biosensing for robust and sensitive molecular diagnostics.

scholarly journals Recent advances and perspectives of nucleic acid detection for coronavirus

2020 ◽  
Vol 10 (2) ◽  
pp. 97-101 ◽  
Author(s):  
Minzhe Shen ◽  
Ying Zhou ◽  
Jiawei Ye ◽  
Abdu Ahmed Abdullah AL-maskri ◽  
Yu Kang ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Nucleic Acid Detection ◽  
Recent Advances

scholarly journals Recent Advances in Biosensors for Nucleic Acid and Exosome Detection

2019 ◽  
Vol 55 (2) ◽  
pp. 86 ◽  
Author(s):  
Zirui Fu ◽  
Yi-Cheng Lu ◽  
James J. Lai
Keyword(s):  
Nucleic Acid ◽  
Recent Advances

Recent advances in the study of nucleic acid flexibility by molecular dynamics

2008 ◽  
Vol 18 (2) ◽  
pp. 185-193 ◽  
Author(s):  
Modesto Orozco ◽  
Agnes Noy ◽  
Alberto Pérez
Keyword(s):  
Molecular Dynamics ◽  
Nucleic Acid ◽  
Recent Advances

scholarly journals Analysis of single nucleic acid molecules in micro- and nano-fluidics

Lab on a Chip ◽  
2016 ◽  
Vol 16 (5) ◽  
pp. 790-811 ◽  
Author(s):  
Sarah M. Friedrich ◽  
Helena C. Zec ◽  
Tza-Huei Wang
Keyword(s):  
Nucleic Acid ◽  
Single Molecule ◽  
Recent Advances ◽  
Single Molecule Analysis

This review discusses recent advances in single molecule analysis of nucleic acid molecules within micro- and nano-fluidic environments.

scholarly journals Recent advances in peptide nucleic acid for cancer bionanotechnology

2017 ◽  
Vol 38 (6) ◽  
pp. 798-805 ◽  
Author(s):  
Jun-chen Wu ◽  
Qing-chun Meng ◽  
Hong-mei Ren ◽  
Hong-tao Wang ◽  
Jie Wu ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Peptide Nucleic Acid ◽  
Recent Advances

scholarly journals DNAzymes, Novel Therapeutic Agents in Cancer Therapy: A Review of Concepts to Applications

2021 ◽  
Vol 2021 ◽  
pp. 1-21
Author(s):  
I. B. K. Thomas ◽  
K. A. P. Gaminda ◽  
C. D. Jayasinghe ◽  
D. T. Abeysinghe ◽  
R. Senthilnithy
Keyword(s):  
Nucleic Acid ◽  
Cancer Therapy ◽  
Cancer Drug ◽  
Clinical Settings ◽  
Full Potential ◽  
In Vivo Models ◽  
Recent Advances ◽  
Catalytic Dna

The past few decades have witnessed a rapid evolution in cancer drug research which is aimed at developing active biological interventions to regulate cancer-specific molecular targets. Nucleic acid-based therapeutics, including ribozymes, antisense oligonucleotides, small interference RNA (siRNA), aptamer, and DNAzymes, have emerged as promising candidates regulating cancer-specific genes at either the transcriptional or posttranscriptional level. Gene-specific catalytic DNA molecules, or DNAzymes, have shown promise as a therapeutic intervention against cancer in various in vitro and in vivo models, expediting towards clinical applications. DNAzymes are single-stranded catalytic DNA that has not been observed in nature, and they are synthesized through in vitro selection processes from a large pool of random DNA libraries. The intrinsic properties of DNAzymes like small molecular weight, higher stability, excellent programmability, diversity, and low cost have brought them to the forefront of the nucleic acid-based therapeutic arsenal available for cancers. In recent years, considerable efforts have been undertaken to assess a variety of DNAzymes against different cancers. However, their therapeutic application is constrained by the low delivery efficiency, cellular uptake, and target detection within the tumour microenvironment. Thus, there is a pursuit to identify efficient delivery methods in vivo before the full potential of DNAzymes in cancer therapy is realized. In this light, a review of the recent advances in the use of DNAzymes against cancers in preclinical and clinical settings is valuable to understand its potential as effective cancer therapy. We have thus sought to firstly provide a brief overview of construction and recent improvements in the design of DNAzymes. Secondly, this review stipulates the efficacy, safety, and tolerability of DNAzymes developed against major hallmarks of cancers tested in preclinical and clinical settings. Lastly, the recent advances in DNAzyme delivery systems along with the challenges and prospects for the clinical application of DNAzymes as cancer therapy are also discussed.

scholarly journals Recent advances in the nucleic acid-based diagnostic tool for coronavirus

2020 ◽  
Vol 47 (11) ◽  
pp. 9033-9041
Author(s):  
Pranav Kumar Prabhakar ◽  
Jyoti Lakhanpal
Keyword(s):  
Nucleic Acid ◽  
Diagnostic Tool ◽  
Recent Advances

Recent advances in the development of peptide nucleic acid as a gene-targeted drug

2004 ◽  
Vol 4 (3) ◽  
pp. 337-348 ◽  
Author(s):  
Violeta L Marin ◽  
Subhadeep Roy ◽  
Bruce A Armitage
Keyword(s):  
Nucleic Acid ◽  
Peptide Nucleic Acid ◽  
Recent Advances ◽  
Targeted Drug
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