scholarly journals Spectrophotometric Methods as Solutions to Pharmaceutical Analysis of β-Lactam Antibiotics

10.5772/48062 ◽  
2012 ◽  
Author(s):  
Judyta Cielecka-Piontek ◽  
Przemysaw Zalewski ◽  
Anna Krause ◽  
Marek Milewski
Keyword(s):  
Pharmaceutical Analysis ◽  
Spectrophotometric Methods

scholarly journals Spectrophotometric Determination of Antidepressant Drug Duloxetine in Pharmaceutical Preparations using π-Acceptors

2012 ◽  
Vol 9 (1) ◽  
pp. 323-329 ◽  
Author(s):  
Sidika Ertürk Toker ◽  
Armagan Önal
Keyword(s):  
Spectrophotometric Determination ◽  
Electron Donor ◽  
Pharmaceutical Analysis ◽  
Antidepressant Drug ◽  
Pharmaceutical Preparations ◽  
Reaction Conditions ◽  
Colored Complex ◽  
Complex Species ◽  
Spectrophotometric Methods

In this study, two simple and accurate spectrophotometric methods were presented for the determination of duloxetine hydrochloride (DLX) in pharmaceutical preparations. The methods were based on the reaction of DLX asn-electron donor with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) and 7,7,8,8-tetracyanoquinodimethane (TCNQ) as π-acceptors to give highly colored complex species. The colored products were quantitated spectro-photometrically at 477 and 841 for DDQ, TCNQ, respectively. All variables were studied in order to optimize the reaction conditions. Beer's law was obeyed in the concentration ranges 10.0-50.0 and 15-60 μg mL−1for DDQ and TCNQ method, respectively. The proposed methods have been successfully applied to the pharmaceutical analysis without any interference from excipients. The suggested procedures could be used for the determination of DLX in pharmaceutical preparations being sensitive, simple and selective.

Green Pharmaceutical Analysis of Drugs Coformulated with Highly Different Concentrations Using Spiking and Manipulation of Their Ratio Spectra

2017 ◽  
Vol 100 (4) ◽  
pp. 985-991 ◽  
Author(s):  
Bassam M Ayoub
Keyword(s):  
Simultaneous Determination ◽  
Analysis Of Variance ◽  
Pharmaceutical Analysis ◽  
Environmentally Friendly ◽  
Pharmaceutical Products ◽  
International Conference ◽  
Spectrophotometric Methods ◽  
Validation Parameters

Abstract Introducing green analysis to pharmaceutical products is considered a significant approach to preserving the environment. This method can be an environmentally friendly alternative to the existing methods, accompanied by a validated automated procedure for the analysis of a drug with the lowest possible number of samples. Different simple spectrophotometric methods were developed for the simultaneous determination of empagliflozin (EG) and metformin (MT) by manipulating their ratio spectra in their application on a recently approved pharmaceutical combination, Synjardy tablets. A spiking technique was used to increase the concentration of EG in samples prepared from the tablets to allow for the simultaneous determination of EG with MT without prior separation. Validation parameters according to International Conference on Harmonization guidelines were acceptable over a concentration range of 2–12 μg/mL for both drugs using derivative ratio and ratio subtraction coupled with extended ratio subtraction. The optimized methods were compared using one-way analysis of variance and proved to be suitable as ecofriendly approaches for industrial QC laboratories.

Simultaneous Spectrophotometric Estimation of Paroxetine Hydrochlorides and Clonazepam in Bulk and Tablet Dosage Form

2021 ◽  
pp. 2497-2501
Author(s):  
Sonali S. Gadge
Keyword(s):  
Sample Preparation ◽  
Pharmaceutical Analysis ◽  
Dosage Form ◽  
Quantitative Estimation ◽  
High Sensitivity ◽  
Correction Method ◽  
Spectrophotometric Methods ◽  
Paroxetine Hydrochloride ◽  
Tablet Dosage ◽  
Instrumental Methods

Two novel simple, accurate and precise spectrophotometric methods have been developed for quantitative estimation of Paroxetine hydrochloride and Clonazepam in the tablet dosage form. The standard stock solution was prepared by using the solvent methanol and further dilutions were carried out by using 0.1 N HCl. The method I is Vierodt’s Simultaneous method in which 291.60nm and 272.27nm was selected for estimation of Paroxetine and Clonazepam respectively, while method II is Absorbance Correction method, where 325 nm and 291nm was selected for estimation of Paroxetine hydrochloride and Clonazepam respectively. The calibration curve was plotted of the concentration range of 0.5-30μg/ml for both the drugs. Both the drugs obeyed Beer’s law in the concentration range 0.5-30μg/ml, correlation coefficient (r2<1). The precision of both the methods was found satisfactorily. The values of relative standards were not more than 2%. Both methods were validated statistically and recovery studies were carried out to confirm the accuracy. Commercial tablet formulation was successfully analyzed using the developed methods. Both these methods can be used for routine analysis for the estimation of Paroxetine hydrochloride and Clonazepam in the combined formulation. Due to the high sensitivity and simple sample preparation, the methods described can be used for undergraduate studies. Hence simple spectrophotometric methods have more advantages over sophisticated instrumental analysis such as HPLC. Hence these two simple and economical, instrumental methods always have a role in pharmaceutical analysis.

Determination of Pharmaceuticals by UV-Visible Spectrophotometry

2020 ◽  
Vol 17 ◽  
Author(s):  
Avvaru Praveen Kumar ◽  
Deepak Kumar
Keyword(s):  
Pharmaceutical Analysis ◽  
Method Development ◽  
Developmental Stages ◽  
Raw Materials ◽  
Storage Conditions ◽  
Maximum Function ◽  
Visible Spectrophotometry ◽  
Spectrophotometric Methods ◽  
Drug Molecules ◽  
Uv Visible

: Pharmaceuticals are the chemical molecules which invented to improve the life of living things through diagnosing, curing, treating or preventing diseases. Pharmaceuticals can do their maximum function or work against disease or prevent from harmful effects of diseases only if they are free from impurities. The pharmaceutical analysis consists of different essential and important procedures to ascertain “identity, strength, quality and purity” of drug molecules. There are three different possibilities to originate impurities which include (i) at the developmental stages of pharmaceuticals, (ii) at the time of transportation, and (iii) storage conditions. So, the pharmaceuticals must be examined at all stages and the impurities should be discovered and quantified. Pharmaceutical analysis also admits analysis of intermediates and raw materials during synthesis of drug molecules. Instrumentation is required to perform pharmaceutical analysis and methods can be developed to certain required levels. This review affords basic theory of UV-Visible spectrophotometry and its applications, pharmaceutical method development and validation, and a list of some reported spectrophotometric methods which are employed in pharmaceutical analysis during 2011 to 2020.

scholarly journals Development and Validation of Methods of Quantitative Determination of Loratadine in Tablets

2016 ◽  
Vol 8 (2) ◽  
pp. 62
Author(s):  
L. S. Logoyda ◽  
O. B. Polyauk ◽  
D. B. Korobko ◽  
M. B. Chir
Keyword(s):  
Quantitative Determination ◽  
Analytical Methods ◽  
Pharmaceutical Analysis ◽  
Spectrophotometric Methods ◽  
Differential Spectrophotometry ◽  
Validation Parameters ◽  
Application Methods ◽  
Determination Of Parameters ◽  
Development And Validation

<p>Methods for the quantitative determination of loratadine tablets by differential spectrophotometry and photo-colorimetry have been developed. During the procedure parameters (range of application methods, stability, specificity, robasnist, convergence, internal laboratory accuracy (precision), accuracy, reproducibility) have been considered. The results indicate that the method photo-colorimetry has not met modern criteria for analytical methods for quantitative determination of parameters such as stability, accuracy and linearity, so other validation parameters (robasnist, convergence and inter-laboratory precision) have been determined only by spectrophotometric methods. It is found that the technique of quantitative determination of loratadine by differential spectrophotometry is accurate, correct, reproducible and linear, to determine its suitability for use in pharmaceutical analysis.</p>

GESTOGENS IN CORPUS LUTEUM OF CATTLE

1960 ◽  
Vol XXXIII (III) ◽  
pp. 417-427 ◽  
Author(s):  
John Kristoffersen
Keyword(s):  
Corpus Luteum ◽  
Average Value ◽  
Spectrophotometric Methods ◽  
The Third ◽  
Quantitative Measurements ◽  
Before And After ◽  
Luteal Tissue ◽  
In Pregnancy

ABSTRACT By means of chromatographic and spectrophotometric methods progesterone and a substance closely similar to 20β-hydroxy-pregn-4-ene-3-one has been detected in luteal tissue from non-pregnant and pregnant cows. In 21 animals quantitative measurements based on a method giving an average net recovery of 56 per cent showed that in pregnancy the average progesterone content in the corpus luteum reached a maximum in the third to fifth month, with low values before and after this period. For 6 nonpregnant cows, the average value was 20.2 μg/g tissue, which is considerably higher than previous values reported in the literature. The relation between these findings and the bovine dependence on a functional corpus luteum in pregnancy is discussed, and it is pointed out that more information about the metabolism of progesterone in cattle is highly desirable.

Colorimetric Determination of Amoxicillin in Pure and some Pharmaceutical Formulations Via Reaction with Potassium Permanganate as Oxidant Reagent

2019 ◽  
Vol 10 (02) ◽  
Author(s):  
Abbas Shebeeb Al-kadumi ◽  
Sahar Rihan Fadhel ◽  
Mohammed Abdullah Ahmed ◽  
Luma Amer Musa
Keyword(s):  
Potassium Permanganate ◽  
Pharmaceutical Preparations ◽  
Pharmaceutical Formulations ◽  
Atomic Emission ◽  
Basic Medium ◽  
Photometric Method ◽  
Colorimetric Determination ◽  
Spectrophotometric Methods ◽  
Label Claim

We proposed two simple, rapid, and convenient spectrophotometric methods are described for the determination of Amoxicillin in bulk and its pharmaceutical preparations. They are based on the measurement of the flame atomic emission of potassium ion (in first method) and colorimetric determination of the green colored solution for manganite ion at 610 nm formed after reaction of Amoxicillin with potassium permanganate as oxidant agent (in the second method) in basic medium. The working conditions of the methods were investigated and optimized. Beer's law plot showed a good correlation in the concentration range of 5-45 μg/ml. The detection limits and relative standared deviations were (2.573, 2.814 μg/ml) (2.137, 2.498) for the flame emission photometric method and (1.844, 2.016 μg/ml) (1.645,1.932) for colorimetric methods for capsules and suspensions respectively. The methods were successfully applied to the determination of Amoxicillin in capsules and suspensions, and the obtained results were in good agreement with the label claim. No interference was observed from the commonly encountered additives and expectancies.

Chemical-pharmaceutical analysis of original and generic tamsulosin preparations

2019 ◽  
Vol 11 (1) ◽  
pp. 32-42
Author(s):  
A.V. Moskalev ◽  
◽  
A.G. Ogiyenko ◽  
S.A. Myz ◽  
A.A. Ogiyenko ◽  
...  
Keyword(s):  
Pharmaceutical Analysis
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