scholarly journals Focus on Bisphenol A, an Uncertain Environmental Pollutant

Carcinogen ◽  
10.5772/48041 ◽  
2012 ◽  
Author(s):  
Salvatore Sciacca ◽  
Gea Oliveri ◽  
Maria Fiore ◽  
Margherita Ferrante
Keyword(s):  
Bisphenol A ◽  
Environmental Pollutant

Effect of the environmental pollutant bisphenol A dimethacylate (BAD) on Ca2+ movement and viability in OC2 human oral cancer cells

2013 ◽  
Vol 35 (2) ◽  
pp. 178-184 ◽  
Author(s):  
Jau-Min Chien ◽  
Chiang-Ting Chou ◽  
Yi-Chau Lu ◽  
Ti Lu ◽  
Chao-Chuan Chi ◽  
...  
Keyword(s):  
Oral Cancer ◽  
Bisphenol A ◽  
Cancer Cells ◽  
Environmental Pollutant ◽  
Oral Cancer Cells

scholarly journals Exposure to a “safe” dose of environmental pollutant bisphenol A elevates oxidative stress and modulates vasoactive system in hypertensive rats

2021 ◽  
pp. 096032712110532
Author(s):  
Manigandan Nagarajan ◽  
Boobalan Raja ◽  
Jeganathan Manivannan
Keyword(s):  
Adverse Effects ◽  
Bisphenol A ◽  
Thiobarbituric Acid ◽  
Environmental Pollutant ◽  
Ros Generation ◽  
Thiobarbituric Acid Reactive Substances ◽  
Hypertensive Rats ◽  
Liver And Kidney ◽  
Ace Activity ◽  
Safe Dose

Due to the prevalence of hypertension (one of the major risk factors of CVD) in the population, it is necessary to explore the adverse effects of daily tolerable and “safe” dose of bisphenol A (BPA) under hypertensive conditions. The current study exposed the Nω-nitro-l-arginine methyl ester (L-NAME, 40 mg/kg b.w/day) induced hypertensive Wistar rats to BPA (50 μg/kg b.w/day) by oral administration along with appropriate controls for 30 days period. The results illustrate that a ‘safe’ dose of BPA does not influence the systolic blood pressure (SBP) and levels of circulatory biomarkers of tissue damage. On the other hand, BPA exposure significantly ( p < 0.05) elevates the thiobarbituric acid reactive substances (TBARS) content in plasma and tissues (heart, aorta, liver and kidney) in hypertensive rats when compared with respective control (BPA alone exposed) rats. Similarly, a significant modulation of ROS generation in RBC, plasma nitric oxide (NO) level and angiotensin-converting enzyme (ACE) activity was observed only under hypertensive milieu. In conclusion, the observed adverse effects during ‘safe’ dose of BPA exposure are specific to the hypertensive condition. Therefore, a precise investigation to explore the effects of BPA exposure in vulnerable hypertensive populations is highly suggested.

Simultaneous analysis of bisphenol A fractions in maternal and fetal compartments in early second trimester of pregnancy

2019 ◽  
Vol 47 (7) ◽  
pp. 765-770 ◽  
Author(s):  
Monika Zbucka-Krętowska ◽  
Urszula Łazarek ◽  
Wojciech Miltyk ◽  
Iwona Sidorkiewicz ◽  
Piotr Pierzyński ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Amniotic Fluid ◽  
Pregnant Women ◽  
Chromosomal Abnormalities ◽  
Maternal Plasma ◽  
Environmental Pollutant ◽  
Maternal Exposure ◽  
Gas Chromatography Mass Spectrometry ◽  
Permeability Factor ◽  
The Impact

Abstract Background Bisphenol A (BPA) is an estrogenic, endocrine-disrupting compound widely used in the industry. It is also a ubiquitous environmental pollutant. Its presence was confirmed in human fetuses, which results from maternal exposure during pregnancy. The mechanisms behind maternal-fetal transfer, and relationships between pregnant women and fetal exposures remain unclear. The aim of this study was to assess the impact of maternal exposure to BPA on the exposure of the fetus. Methods Maternal plasma and amniotic fluid samples were collected from 52 pregnant women undergoing amniocentesis for prenatal diagnosis of chromosomal abnormalities. BPA was measured by gas chromatography-mass spectrometry (GC-MS). The permeability factor – a ratio of fetal-to-maternal BPA concentration – was used as a measure delineating the transplacental transfer of BPA. Results The median concentration of maternal plasma BPA was 8 times higher than the total BPA concentration in the amniotic fluid (8.69 ng/mL, range: 4.3 ng/mL–55.3 ng/mL vs. median 1.03 ng/mL, range: 0.3 ng/mL–10.1 ng/mL). There was no direct relationship between the levels of BPA in maternal plasma and amniotic fluid levels. The permeability factor, in turn, negatively correlated with fetal development (birth weight) (R = −0.54, P < 0.001). Conclusion Our results suggest that the risk of fetal BPA exposure depends on placental BPA permeability rather than the levels of maternal BPA plasma concentration and support general recommendations to become aware and avoid BPA-containing products.

scholarly journals Exposure to the environmental pollutant bisphenol A diglycidyl ether (BADGE) causes cell over-proliferation in Drosophila

2020 ◽  
Vol 27 (20) ◽  
pp. 25261-25270
Author(s):  
Michael J. Williams ◽  
Hao Cao ◽  
Therese Lindkvist ◽  
Tobias J. Mothes ◽  
Helgi B. Schiöth
Keyword(s):  
Bisphenol A ◽  
Diglycidyl Ether ◽  
Environmental Pollutant ◽  
Bisphenol A Diglycidyl Ether

scholarly journals Sorption of bisphenol A from aqueous solutions using natural adsorbents: isotherm, kinetic and effect of temperature

2021 ◽  
Vol 314 ◽  
pp. 07003
Author(s):  
Nouhaila Hadoudi ◽  
Hassan Amhamdi ◽  
M’hamed Ahari
Keyword(s):  
Bisphenol A ◽  
Negative Impact ◽  
Low Cost ◽  
Environmental Pollutant ◽  
Effect Of Temperature ◽  
Solution Ph ◽  
Natural Adsorbents ◽  
Cost Treatment ◽  
And Performance ◽  
Isothermal Kinetic

Emerging organic micropollutants, such as bisphenol A (BPA), have raised concerns about their negative impact on human health and ecological safety. This review article aims to demonstrate and highlight recent advances in adsorption applications for bisphenol A, a toxic environmental pollutant commonly found in wastewater. There are many reasons to use non-toxic materials and eco-friendly technologies to remove this pollutant from sewage. [1] Several adsorbents previously used have shown significant efficiency and performance for the removal of BPAs, and current research is directed towards the development of low-cost treatment processes using materials such as clays and Chitosan. The properties of the adsorbent can be adjusted by changing their surface for an optimized performance. In addition, the efficiency of the adsorption process depends on various parameters such as solution pH, the pollutant concentration, contact time, temperature, nature and dose of the adsorbent, which are also discussed. In addition, we critically review the isothermal, kinetic and thermodynamic approaches. [2]

scholarly journals Role of neutrophil extracellular traps in chronic kidney injury induced by bisphenol-A

2019 ◽  
Vol 241 (2) ◽  
pp. 125-134 ◽  
Author(s):  
Shiyun Tong ◽  
Shumin Yang ◽  
Ting Li ◽  
Rufei Gao ◽  
Jinbo Hu ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Kidney Injury ◽  
Neutrophil Extracellular Traps ◽  
Environmental Pollutant ◽  
Extracellular Traps ◽  
Chronic Kidney Injury ◽  
Matrix Expansion ◽  
Renal System

Bisphenol-A (BPA) is a common environmental pollutant, and exposure to it is associated with proteinuria and may predict the progression of chronic kidney disease; however, the mechanism is not clear. Neutrophil extracellular traps (NETs) are a DNA skeleton coated with various proteases, and it is associated with various types of autoimmune nephritis. In this study, we examine whether NETs is involved in BPA-induced chronic kidney injury. In vivo, BPA exposure resulted in impaired renal function and altered renal morphology, including glomerular mesangial matrix expansion and increased renal interstitial fibroblast markers. Meanwhile, more dsDNA can be detected in the serum, and the NETs-associated proteins, MPO and citH3 were deposited in the renal system. In vitro, BPA and NETs treatment caused podocyte injury, a loss of marker proteins and disorder in the actin skeleton. After NETs inhibition via DNase administration, BPA-induced injuries were significantly relieved. In conclusion, the increase of NETosis in circulation and the renal system during BPA exposure suggests that NETs may be involved in BPA-induced chronic kidney injury.

scholarly journals Combined Toxicity of Xenobiotics Bisphenol A and Heavy Metals on Zebrafish Embryos (Danio rerio)

Toxics ◽  
2021 ◽  
Vol 9 (12) ◽  
pp. 344
Author(s):  
Davide Di Paola ◽  
Fabiano Capparucci ◽  
Giovanni Lanteri ◽  
Marika Cordaro ◽  
Rosalia Crupi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Bisphenol A ◽  
Environmental Pollutants ◽  
Aquatic Organisms ◽  
Environmental Pollutant ◽  
Zebrafish Embryos ◽  
Zebrafish Larvae ◽  
Oxidative Stress Pathway ◽  
Effective Doses ◽  
Stress Pathway

Environmental pollutants may cause adverse effects on the immune system of aquatic organisms. This study revealed that combination of environmental pollutants and Bisphenol A(BPA) could cause an acute inflammatory response in zebrafish larvae as shown by body alterations, which may imply a common immunotoxicity mechanism for most environmental pollutants. In the present study we evaluated the toxicity after co-exposure of BPA and Cd or Cr (III) in zebrafish embryos and larvae, and the oxidative stress pathway involved. Evaluation of lethal and developmental endpoints such as hatching, edema, malformations, abnormal heart rate and survival rate were evaluated after 96 h of exposure. Combination of BPA at 10 μM with Cd or Cr at 0.5 μM exposure induce malformations at 96 hpf in zebrafish larvae, as well as significantly increases oxidative stress and induce apoptosis on larvae. Our study suggested how environmental pollutant showed a synergistic effect at common not-effective doses, promoting decrease of antioxidant defense and contrasted fish development.

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