scholarly journals Retinoid X Receptor Signalling in the Specification of Skeletal Muscle Lineage

10.5772/45879 ◽  
2012 ◽  
Author(s):  
Melanie Le ◽  
Qiao Li
Keyword(s):  
Skeletal Muscle ◽  
Retinoid X Receptor ◽  
Receptor Signalling

Retinoid-X receptor signalling in the developing spinal cord

Nature ◽  
10.1038/26515 ◽  
1998 ◽  
Vol 395 (6700) ◽  
pp. 398-402 ◽  
Author(s):  
Ludmila Solomin ◽  
Clas B. Johansson ◽  
Rolf H. Zetterström ◽  
Reid P. Bissonnette ◽  
Richard A. Heyman ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Retinoid X Receptor ◽  
Receptor Signalling ◽  
Developing Spinal Cord

scholarly journals Contribution of Retinoid X Receptor Signaling to the Specification of Skeletal Muscle Lineage

2011 ◽  
Vol 286 (30) ◽  
pp. 26806-26812 ◽  
Author(s):  
Melanie Le May ◽  
Hymn Mach ◽  
Natascha Lacroix ◽  
Chenchen Hou ◽  
Jihong Chen ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Retinoid X Receptor ◽  
Receptor Signaling

scholarly journals Retinoid X Receptor γ-Deficient Mice Have Increased Skeletal Muscle Lipoprotein Lipase Activity and Less Weight Gain when Fed a High-Fat Diet

Endocrinology ◽  
2004 ◽  
Vol 145 (8) ◽  
pp. 3679-3685 ◽  
Author(s):  
Bryan R. Haugen ◽  
Dalan R. Jensen ◽  
Vibha Sharma ◽  
Leslie K. Pulawa ◽  
William R. Hays ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Weight Gain ◽  
Lipoprotein Lipase ◽  
Lipase Activity ◽  
High Fat Diet ◽  
Retinoid X Receptor ◽  
Lipoprotein Lipase Activity ◽  
High Fat ◽  
Deficient Mice

Retinoid X receptor expression in skeletal muscle of nondiabetic, obese and type 2 diabetic individuals

Metabolism ◽  
2001 ◽  
Vol 50 (7) ◽  
pp. 830-834 ◽  
Author(s):  
E. Codner ◽  
M. Loviscach ◽  
T.P. Ciaraldi ◽  
N. Rehman ◽  
L. Carter ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Retinoid X Receptor ◽  
Receptor Expression ◽  
Type 2 Diabetic

scholarly journals Regulation of SREBP1c Gene Expression in Skeletal Muscle: Role of Retinoid X Receptor/Liver X Receptor and Forkhead-O1 Transcription Factor

Endocrinology ◽  
2008 ◽  
Vol 149 (5) ◽  
pp. 2293-2305 ◽  
Author(s):  
Yasutomi Kamei ◽  
Shinji Miura ◽  
Takayoshi Suganami ◽  
Fumiko Akaike ◽  
Sayaka Kanai ◽  
...  
Keyword(s):  
Gene Expression ◽  
Skeletal Muscle ◽  
Transcription Factor ◽  
Transgenic Mice ◽  
Regulatory Element ◽  
Liver X Receptor ◽  
Retinoid X Receptor ◽  
Dominant Negative

Sterol regulatory element binding protein 1c (SREBP1c) is a master regulator of lipogenic gene expression in liver and adipose tissue, where its expression is regulated by a heterodimer of nuclear receptor-type transcription factors retinoid X receptor-α (RXRα) and liver X receptor-α (LXRα). Despite the potential importance of SREBP1c in skeletal muscle, little is known about the regulation of SREBP1c in that setting. Here we report that gene expression of RXRγ is markedly decreased by fasting and is restored by refeeding in mouse skeletal muscle, in parallel with changes in gene expression of SREBP1c. RXRγ or RXRα, together with LXRα, activate the SREBP1c promoter in vitro. Moreover, transgenic mice overexpressing RXRγ specifically in skeletal muscle showed increased gene expression of SREBP1c with increased triglyceride content in their skeletal muscles. In contrast, transgenic mice overexpressing the dominant-negative form of RXRγ showed decreased SREBP1c gene expression. The expression of Forkhead-O1 transcription factor (FOXO1), which can suppress the function of multiple nuclear receptors, is negatively correlated to that of SREBP1c in skeletal muscle during nutritional change. Moreover, transgenic mice overexpressing FOXO1 specifically in skeletal muscle exhibited decreased gene expression of both RXRγ and SREBP1c. In addition, FOXO1 suppressed RXRα/LXRα-mediated SREBP1c promoter activity in vitro. These findings provide in vivo and in vitro evidence that RXR/LXR up-regulates SREBP1c gene expression and that FOXO1 antagonizes this effect of RXR/LXR in skeletal muscle.

Imposex induction is mediated through the Retinoid X Receptor signalling pathway in the neogastropod Nucella lapillus

2007 ◽  
Vol 85 (1) ◽  
pp. 57-66 ◽  
Author(s):  
L. Filipe C. Castro ◽  
D. Lima ◽  
A. Machado ◽  
C. Melo ◽  
Y. Hiromori ◽  
...  
Keyword(s):  
Retinoid X Receptor ◽  
Signalling Pathway ◽  
Nucella Lapillus ◽  
Receptor Signalling
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