scholarly journals Cell Based Therapy for Chronic Liver Disease: Role of Fetal Liver Cells in Restoration of the Liver Cell Functions

10.5772/45876 ◽  
2012 ◽  
Author(s):  
Chaturvedula Tripura ◽  
Aleem Khan ◽  
Gopal Pande
2021 ◽  
Vol 22 (12) ◽  
pp. 6326
Author(s):  
Jung A. Eom ◽  
Goohyun Kwon ◽  
Nayeon Kim ◽  
Eunju Park ◽  
Sungmin Won ◽  
...  

The gut microbiota has been known to modulate the immune responses in chronic liver diseases. Recent evidence suggests that effects of dietary foods on health care and human diseases are related to both the immune reaction and the microbiome. The gut-microbiome and intestinal immune system play a central role in the control of bacterial translocation-induced liver disease. Dysbiosis, small intestinal bacterial overgrowth, translocation, endotoxemia, and the direct effects of metabolites are the main events in the gut-liver axis, and immune responses act on every pathways of chronic liver disease. Microbiome-derived metabolites or bacteria themselves regulate immune cell functions such as recognition or activation of receptors, the control of gene expression by epigenetic change, activation of immune cells, and the integration of cellular metabolism. Here, we reviewed recent reports about the immunologic role of gut microbiotas in liver disease, highlighting the role of diet in chronic liver disease.


2016 ◽  
Vol 22 ◽  
pp. 2144-2151 ◽  
Author(s):  
Sandra Milic ◽  
Ivana Mikolasevic ◽  
Lidija Orlic ◽  
Edita Devcic ◽  
Nada Starcevic-Cizmarevic ◽  
...  

2020 ◽  
Vol 40 (02) ◽  
pp. 180-188 ◽  
Author(s):  
Christine E. Dolin ◽  
Gavin E. Arteel

AbstractChronic fatty liver disease is common worldwide. This disease is a spectrum of disease states, ranging from simple steatosis (fat accumulation) to inflammation, and eventually to fibrosis and cirrhosis if untreated. The fibrotic stage of chronic liver disease is primarily characterized by robust accumulation of extracellular matrix (ECM) proteins (collagens) that ultimately impairs the function of the organ. The role of the ECM in early stages of chronic liver disease is less well-understood, but recent research has demonstrated that several changes in the hepatic ECM in prefibrotic liver disease are not only present but may also contribute to disease progression. The purpose of this review is to summarize the established and proposed changes to the hepatic ECM that may contribute to inflammation during earlier stages of disease development, and to discuss potential mechanisms by which these changes may mediate the progression of the disease.


Hepatology ◽  
1999 ◽  
Vol 29 (3) ◽  
pp. 883-888 ◽  
Author(s):  
Thomas R. Frieden ◽  
Lisa Ozick ◽  
Colin McCord ◽  
Omana V. Nainan ◽  
Sara Workman ◽  
...  

2021 ◽  
Vol 67 (2) ◽  
Author(s):  
Elton DAJTI ◽  
Giovanni MARASCO ◽  
Federico RAVAIOLI ◽  
Luigina V. ALEMANNI ◽  
Benedetta ROSSINI ◽  
...  

1996 ◽  
Vol 35 (5) ◽  
pp. 416-418 ◽  
Author(s):  
Tohru IZUMI ◽  
Ryuhei SASAKI ◽  
Saburo TSUNODA ◽  
Makio HATAKEYAMA ◽  
Hirotaka KOYAMA ◽  
...  

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